Results 21 to 30 of about 1,825,906 (262)

Model simplification of signal transduction pathway networks via a hybrid inference strategy [PDF]

, 2008
A full-scale mathematical model of cellular networks normally involves a large number of variables and parameters. How to effectively develop manageable and reliable models is crucial for effective computation, analysis and design of such systems.
Yue, Hong, Jia, Jianfang
core   +3 more sources

Phosphatidylethanolamine-binding protein 4 deficiency exacerbates carbon tetrachloride-induced liver fibrosis by regulating the NF-κB signaling pathway

Frontiers in Pharmacology, 2022
Liver fibrosis is a pathological process which can progress to hepatocirrhosis, even hepatocellular carcinoma. Phosphatidylethanolamine-binding protein 4 (PEBP4) is a secreted protein involved in regulating many molecular pathways, whereas its roles in ...
Qianqian Luo, Yuanyi Ling, Yuanyi Ling, Yufei Li, Xiaoqin Qu, Qiaoqing Shi, Shuangyan Zheng, Yanhong Li, Yonghong Huang, Yonghong Huang, Xiaoyan Zhou, Xiaoyan Zhou   +11 more
doaj   +1 more source

How to Inhibit Nuclear Factor-Kappa B Signaling: Lessons from Poxviruses

Pathogens, 2022
The Nuclear Factor-kappa B (NF-κB) family of transcription factors regulates key host inflammatory and antiviral gene expression programs, and thus, is often activated during viral infection through the action of pattern-recognition receptors and ...
Joshua B. Reus, Emily A. Rex, Don B. Gammon   +2 more
doaj   +1 more source

Sensitivity analysis and experimental design of a stiff signal transduction pathway model [PDF]

, 2007
Sensitivity analysis is normally used to analyze how sensitive a system is with respect to the change of parameters or initial conditions and is perhaps best known in systems biology via the formalism of metabolic control analysis [1, 2].
Yue, H., Jia, J.F., Brown, M., Wang, H., Kell, D.B.   +4 more
core   +2 more sources

IRF3 and IRF8 Regulate NF-κB Signaling by Targeting MyD88 in Teleost Fish

Frontiers in Immunology, 2020
MyD88 is a conserved intracellular adaptor, which plays an important role in the innate immune system. MyD88 transmits signals for downstream of toll-like and IL-1 receptors to activate NF-κB signaling pathway, which is tightly controlled in the immune ...
Xiaolong Yan, Xiaolong Yan, Xueyan Zhao, Ruixuan Huo, Tianjun Xu, Tianjun Xu, Tianjun Xu, Tianjun Xu, Tianjun Xu   +8 more
doaj   +1 more source

Inhibition of BET Protein Function Suppressed the Overactivation of the Canonical NF-κB Signaling Pathway in 6-OHDA-Lesioned Rat Model of Levodopa-Induced Dyskinesia

Frontiers in Neuroscience, 2022
BackgroundNeuroinflammation is involved in the mechanisms of levodopa-induced dyskinesia (LID). The canonical NF-κB activation signaling pathway plays a critical role in the neuroinflammation development and BET protein-induced NF-κB-mediated ...
Ying Wan, Li Han, Lu Rong, Shuyuan Yang, Lu Song, Na Wu, Zhenguo Liu, Jing Gan   +7 more
doaj   +1 more source

Effect of canonical NF-κB signaling pathway on the differentiation of rat dental epithelial stem cells

Stem Cell Research & Therapy, 2019
Background Nuclear factor-κB (NF-κB), an important transcription factor, participates in many physiological and pathological processes such as growth, differentiation, organogenesis, apoptosis, inflammation, and immune response, including tooth ...
Yan Liang, Guoqing Chen, Yuzhi Yang, Ziyue Li, Tian Chen, Wenhua Sun, Mei Yu, Kuangwu Pan, Weihua Guo, Weidong Tian   +9 more
doaj   +1 more source

WITHDRAWN: Inhibition of CHOP weakens the promotion of chronic intermittent hypoxia on epithelial cells apoptosis via inhibiting PI3K-Akt and NF-κB signaling pathways

Oncotarget, 2017
// Yi-Bin Wang 1, * , Yin Ni 2, * , Ren-Hua Sun 2 , Xiao-Zhou Mou 3 , Fang Han 2 , Qian Li 2 , Hai-Jun Huang 4 , Jing-Quan Liu 2 and Yue-Xing Tu 2 1 Department of Cardiology, Chun’an First People’s Hospital, Zhejiang Provincial People’s Hospital Chun’an Branch, Hangzhou, Zhejiang 311700, China 2 Department of Critical Care Medicine ...
Yi-Bin Wang, Yi-Bin Wang, Yin Ni, Yin Ni, Ren-Hua Sun, Ren-Hua Sun, Xiao-Zhou Mou, Xiao-Zhou Mou, Fang Han, Fang Han, Qian Li, Qian Li, Hai-Jun Huang, Hai-Jun Huang, Jing-Quan Liu, Jing-Quan Liu, Yue-Xing Tu, Yue-Xing Tu   +17 more
openaire   +1 more source

Anaplasma phagocytophilum Activates NF-κB Signaling via Redundant Pathways

Frontiers in Public Health, 2020
Anaplasma phagocytophilum subverts neutrophil function permitting intracellular survival, propagation and transmission. Sustained pro-inflammatory response, recruitment of new host cells for population expansion, and delayed apoptosis are associated with
J. Stephen Dumler, J. Stephen Dumler, Marguerite Lichay, Wan-Hsin Chen, Kristen E. Rennoll-Bankert, Jin-ho Park   +5 more
doaj   +1 more source

CircRNF10-DHX15 interaction suppressed breast cancer progression by antagonizing DHX15-NF-κB p65 positive feedback loop

Cellular & Molecular Biology Letters, 2023
Background Breast cancer (BC) is a common threat to women. The continuous activation of nuclear factor kappa B (NF-κB) signaling pathway contributes to the development of BC.
Wenfang Zheng, Xuehui Wang, Yunhe Yu, Changle Ji, Lin Fang   +4 more
doaj   +1 more source