Results 1 to 10 of about 303,295 (303)
Cells, 2022 The mitogen-activated protein kinase (MAPK) signaling pathway is a well-conserved intracellular signal transduction pathway, and has important roles in mammalian reproduction.
Zijie Huang +5 more
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Journal of Diabetes Research, 2017 Diabetic peripheral neuropathy (DPN) is a common complication of diabetes mellitus (DM). It is not diagnosed or managed properly in the majority of patients because its pathogenesis remains controversial.
Lin Luo +7 more
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MAPK Signaling Pathway May Directly Regulate the Expression of Hydrophobin Genes in Flammulina filiformis [PDF]
Journal of FungiFungal hydrophobins reduce the surface tension of hyphae so that hyphae can grow into the air. Reduced expression of hydrophobin genes results in abnormal morphogenesis of both hyphae and the fruiting body of Flammulina filiformis.
Qianhui Huang +7 more
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Mechanisms of the JNK/p38 MAPK signaling pathway in drug resistance in ovarian cancer [PDF]
Frontiers in OncologyOvarian cancer (OC) is the most lethal malignancy in the female reproductive system, and chemotherapy drug resistance is the main cause of treatment failure.
Yu-Ting Ma +6 more
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PTPRK promotes resiniferatoxin-induced postherpetic neuralgia via activating DUSP1/p38 MAPK signaling pathway in dorsal root ganglia [PDF]
Scientific ReportsPostherpetic neuralgia (PHN) is a chronic pain condition that develops in the area of a previous herpes zoster (shingles) infection. Protein tyrosine phosphatase receptor type K (PTPRK) encodes a receptor-type protein tyrosine phosphatase involved in ...
Yong Zhao +5 more
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Organophosphorus Compounds and MAPK Signaling Pathways [PDF]
International Journal of Molecular Sciences, 2020 The molecular signaling pathways that lead to cell survival/death after exposure to organophosphate compounds (OPCs) are not yet fully understood. Mitogen-activated protein kinases (MAPKs) including the extracellular signal-regulated protein kinase (ERK), the c-Jun NH2-terminal kinase (JNK), and the p38-MAPK play the leading roles in the transmission ...
Tahereh Farkhondeh +5 more
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The Role of PI3K/AKT and MAPK Signaling Pathways in Erythropoietin Signalization [PDF]
International Journal of Molecular Sciences, 2021 Erythropoietin (EPO) is a glycoprotein cytokine known for its pleiotropic effects on various types of cells and tissues. EPO and its receptor EPOR trigger signaling cascades JAK2/STAT5, MAPK, and PI3K/AKT that are interconnected and irreplaceable for cell survival. In this article, we describe the role of the MAPK and PI3K/AKT signaling pathways during
Zuzana Tóthová +5 more
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Understanding MAPK Signaling Pathways in Apoptosis [PDF]
International Journal of Molecular Sciences, 2020 MAPK (mitogen-activated protein kinase) signaling pathways regulate a variety of biological processes through multiple cellular mechanisms. In most of these processes, such as apoptosis, MAPKs have a dual role since they can act as activators or inhibitors, depending on the cell type and the stimulus.
Yue, Jicheng, López, José M.
openaire +2 more sources
Identification of the Crucial Gene in Overflow Arteriovenous Fistula by Bioinformatics Analysis
Frontiers in Physiology, 2021 Objective: The aim was to study the preliminary screening of the crucial genes in intimal hyperplasia in the venous segment of arteriovenous (AV) fistula and the underlying potential molecular mechanisms of intimal hyperplasia with bioinformatics ...
Zhengde Zhao +5 more
doaj +1 more source
The roles of MAPK signaling pathway in ovarian folliculogenesis. [PDF]
J Ovarian ResAbstract Ovarian folliculogenesis is a complex biological process critical for female fertility, intricately regulated by various signaling pathways, among which the Mitogen-Activated Protein Kinase (MAPK) signaling pathway plays a pivotal role.
Zhao H, Dinh TH, Wang Y, Yang Y.
europepmc +3 more sources