Mechanisms of the JNK/p38 MAPK signaling pathway in drug resistance in ovarian cancer [PDF]
Frontiers in OncologyOvarian cancer (OC) is the most lethal malignancy in the female reproductive system, and chemotherapy drug resistance is the main cause of treatment failure.
Yu-Ting Ma +6 more
doaj +2 more sources
PTPRK promotes resiniferatoxin-induced postherpetic neuralgia via activating DUSP1/p38 MAPK signaling pathway in dorsal root ganglia [PDF]
Scientific ReportsPostherpetic neuralgia (PHN) is a chronic pain condition that develops in the area of a previous herpes zoster (shingles) infection. Protein tyrosine phosphatase receptor type K (PTPRK) encodes a receptor-type protein tyrosine phosphatase involved in ...
Yong Zhao +5 more
doaj +2 more sources
The Significance of MAPK Signaling Pathway in the Diagnosis and Subtype Classification of Intervertebral Disc Degeneration [PDF]
JOR SpineBackground Intervertebral disc degeneration (IDD) is a human aging disease related mainly to inflammation, cellular senescence, RNA/DNA methylation, and ECM.
Yong Liu +6 more
doaj +2 more sources
Identification of the Crucial Gene in Overflow Arteriovenous Fistula by Bioinformatics Analysis
Frontiers in Physiology, 2021 Objective: The aim was to study the preliminary screening of the crucial genes in intimal hyperplasia in the venous segment of arteriovenous (AV) fistula and the underlying potential molecular mechanisms of intimal hyperplasia with bioinformatics ...
Zhengde Zhao +5 more
doaj +1 more source
Astragaloside IV Ameliorates Myocardial Infarction Induced Apoptosis and Restores Cardiac Function
Frontiers in Cell and Developmental Biology, 2021 BackgroundType 2 diabetes mellitus increases the risk of cardiovascular disease including myocardial infarction (MI). Inflammation and apoptosis have been implicated in the pathophysiology of MI.
Chuang Sun +8 more
doaj +1 more source
MAPK pathway: Potential role in glioblastoma multiforme
Interdisciplinary Neurosurgery, 2021 Glioblastoma multiforme (GBM) is one of the most aggressive and damaging tumors of the brain. For successful therapy of GBM exact pathways need to be explored for developing effective targeted chemotherapeutic agents.
Kowthavarapu V. Krishna +4 more
doaj +1 more source
MAPK pathway activation selectively inhibits ASCL1-driven small cell lung cancer
iScience, 2021 Summary: Activation of mitogenic signaling pathways is a common oncogenic driver of many solid tumors including lung cancer. Although activating mutations in the mitogen-activated protein kinase (MAPK) pathway are prevalent in non-small cell lung cancers,
Rebecca Caeser +15 more
doaj +1 more source
IGF-1 regulates Cyr61 induced breast cancer cell proliferation and invasion. [PDF]
, 2014 BackgroundStudies from our laboratory and others have shown that cysteine-rich 61 (Cyr61) may be involved in tumor proliferation and invasion. In earlier studies, we demonstrated increased insulin-like growth factor-I (IGF-1) is associated with breast ...
Cardenas, Jessica +5 more
core +15 more sources
Cells, 2022 The mitogen-activated protein kinase (MAPK) signaling pathway is a well-conserved intracellular signal transduction pathway, and has important roles in mammalian reproduction.
Zijie Huang +5 more
doaj +1 more source
Mechanisms of action of hESC-secreted proteins that enhance human and mouse myogenesis. [PDF]
, 2014 Adult stem cells grow poorly in vitro compared to embryonic stem cells, and in vivo stem cell maintenance and proliferation by tissue niches progressively deteriorates with age.
CONBOY, Irina M +6 more
core +6 more sources