Results 31 to 40 of about 288,292 (262)
PTPIP51 Crosslinks the NFκB Signaling and the MAPK Pathway in SKBR3 Cells [PDF]
Future Science OA, 2020 PTPIP51 interacts with NFκB signaling at the RelA and IκB level. NFκB signaling is linked to the initiation, progression and metastasis of breast cancer. Her2-amplified breast cancer cells frequently display activation of the NFκB signaling. We aimed to clarify the effects of NFκB inhibition on the NFκB- and MAPK-related interactome of PTPIP51 and cell
Dietel, Eric +5 more
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Phorbol 12-Myristate 13-Acetate Induces MUC16 Expression via PKCδ and p38 in Human Airway Epithelial Cells [PDF]
Clinical and Experimental Otorhinolaryngology, 2012 ObjectivesPhorbol 12-myristate 13-acetate (PMA) is widely used as a protein kinase C (PKC) activator, PKC is involved in the secretion of mucins. MUC16, one of the membrane-bound mucins, is produced in human airway epithelial cells.
Chang Hoon Bae +3 more
doaj +1 more source
eLife, 2017 Injury-induced (Wallerian) axonal degeneration is regulated via the opposing actions of pro-degenerative factors such as SARM1 and a MAPK signal and pro-survival factors, the most important of which is the NAD+ biosynthetic enzyme NMNAT2 that inhibits ...
Lauren J Walker +5 more
doaj +1 more source
Scientific Reports, 2021 Despite extensive research on molecular pathways controlling the process of regeneration in model organisms, little is known about the actual initiation signals necessary to induce regeneration. Recently, the activation of ERK signaling has been shown to
V. Jaenen +7 more
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MAPK/JNK signalling: a potential autophagy regulation pathway [PDF]
Bioscience Reports, 2015 Autophagy refers to a lysosomal degradative pathway or a process of self-cannibalization. This pathway maintains nutrients levels for vital cellular functions during periods of starvation and it provides cells with survival advantages under various stress situations.
Zhou, Yuan-Yuan +3 more
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MAPKs in development: insights from Dictyostelium signaling pathways [PDF]
bmc, 2011 Abstract Mitogen activated protein kinases (MAPKs) play important roles in the development of eukaryotic organisms through the regulation of signal transduction pathways stimulated by external signals. MAPK signaling pathways have been associated with the regulation of cell growth, differentiation, and chemotaxis,
Hadwiger Jeffrey A., Nguyen Hoai-Nghia
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Regulation of MAPK Signaling Pathways by the Large HERC Ubiquitin Ligases
International Journal of Molecular Sciences, 2023 Protein ubiquitylation acts as a complex cell signaling mechanism since the formation of different mono- and polyubiquitin chains determines the substrate’s fate in the cell. E3 ligases define the specificity of this reaction by catalyzing the attachment of ubiquitin to the substrate protein.
Joan Sala-Gaston +5 more
openaire +3 more sources
Frontiers in Cell and Developmental Biology, 2021 Mild hypoxia (5% O2) as well as FGFR1-induced activation of phosphatidylinositol-4,5-bisphosphate 3-kinase/protein kinase B (PI3K/AKT) and MAPK signaling pathways markedly support pluripotency in human pluripotent stem cells (hPSCs).
Petr Fojtík +8 more
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Dexamethasone inhibits repair of human airway epithelial cells mediated by glucocorticoid-induced leucine zipper (GILZ). [PDF]
PLoS ONE, 2013 BACKGROUND: Glucocorticoids (GCs) are a first-line treatment for asthma for their anti-inflammatory effects, but they also hinder the repair of airway epithelial injury.
Jingyue Liu +7 more
doaj +1 more source
Scientific Reports, 2023 An early diagnosis and precise prognosis are critical for the treatment of glioma. The mitogen‑activated protein kinase (MAPK) signaling pathway potentially affects glioma, but the exploration of the clinical values of the pathway remains lacking.
Hengrui Liu, Tao Tang
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