Results 31 to 40 of about 436,308 (305)

MAPK/JNK signalling: a potential autophagy regulation pathway [PDF]

Bioscience Reports, 2015
Autophagy refers to a lysosomal degradative pathway or a process of self-cannibalization. This pathway maintains nutrients levels for vital cellular functions during periods of starvation and it provides cells with survival advantages under various stress situations.
Zhou, Yuan-Yuan, Li, Ying, Jiang, Wei-Qin, Zhou, Lin-Fu   +3 more
openaire   +2 more sources

Gene Expression Profiling Identifies Downregulation of the Neurotrophin-MAPK Signaling Pathway in Female Diabetic Peripheral Neuropathy Patients

Journal of Diabetes Research, 2017
Diabetic peripheral neuropathy (DPN) is a common complication of diabetes mellitus (DM). It is not diagnosed or managed properly in the majority of patients because its pathogenesis remains controversial.
Lin Luo, Wen-Hua Zhou, Jiang-Jia Cai, Mei Feng, Mi Zhou, Su-Pei Hu, Jin Xu, Lin-Dan Ji   +7 more
doaj   +1 more source

Ecological inducers of the yeast filamentous growth pathway reveal environment-dependent roles for pathway components

mSphere, 2023
Signaling modules, such as mitogen-activated protein kinase (MAPK) pathways, are evolutionarily conserved drivers of cell differentiation and stress responses.
Matthew D. Vandermeulen, Paul J. Cullen
doaj   +1 more source

Mathematical model of the cell signaling pathway based on the extended Boolean network model with a stochastic process

BMC Bioinformatics, 2022
Background In cell signaling pathways, proteins interact with each other to determine cell fate in response to either cell-extrinsic (micro-environmental) or intrinsic cues.
Minsoo Kim, Eunjung Kim
doaj   +1 more source

The Role of PI3K/AKT and MAPK Signaling Pathways in Erythropoietin Signalization [PDF]

International Journal of Molecular Sciences, 2021
Erythropoietin (EPO) is a glycoprotein cytokine known for its pleiotropic effects on various types of cells and tissues. EPO and its receptor EPOR trigger signaling cascades JAK2/STAT5, MAPK, and PI3K/AKT that are interconnected and irreplaceable for cell survival. In this article, we describe the role of the MAPK and PI3K/AKT signaling pathways during
Zuzana Tóthová, Martina Šemeláková, Zuzana Solárová, Jana Tomc, Nataša Debeljak, Peter Solár   +5 more
openaire   +3 more sources

The Protective Effect of Beraprost Sodium on Diabetic Nephropathy by Inhibiting Inflammation and p38 MAPK Signaling Pathway in High-Fat Diet/Streptozotocin-Induced Diabetic Rats

International Journal of Endocrinology, 2016
Background. p38 mitogen-activated protein kinase (MAPK) plays a crucial role in regulating signaling pathways implicated in inflammatory processes leading to diabetic nephropathy (DN).
Li Peng, Jie Li, Yixing Xu, Yangtian Wang, Hong Du, Jiaqing Shao, Zhimin Liu   +6 more
doaj   +1 more source

A human MAP kinase interactome. [PDF]

, 2010
Mitogen-activated protein kinase (MAPK) pathways form the backbone of signal transduction in the mammalian cell. Here we applied a systematic experimental and computational approach to map 2,269 interactions between human MAPK-related proteins and other ...
A Friedman, A Karydis, A Lunardi, AA Reszka, AC Gavin, AJ Whitmarsh, BP Kelley, C Widmann, Chih-yuan Chiang, Christopher H Martin, Cornelia Kurschner, D Wang, Diane L Barber, DJ LaCount, GD Bader, GL Johnson, J Kim, J Ptacek, JV Olsen, Jyoti Srivastava, K Hayashi, K Venkatesan, KC Gunsalus, L Chang, L Collin, M Baumgartner, M Karin, M Qi, M Rothe, Merril Gersten, Mike Smoot, P Uetz, PJ Cullen, R Hooley, R Konig, R Konig, R Konig, Russell Bell, S Peri, SA Johnson, SK Chanda, Sourav Bandyopadhyay, SP Denker, Sudhir Sahasrabudhe, Suhaila White, Sumit K Chanda, T Ito, T Reguly, Trey Ideker, W Kolch, W Kolch, Y Ho   +51 more
core   +3 more sources

CRAF R391W is a melanoma driver oncogene. [PDF]

, 2016
Approximately 75% of melanomas have known driver oncogenic mutations in BRAF, NRAS, GNA11 or GNAQ, while the mutations providing constitutive oncogenic signaling in the remaining melanomas are not known.
Atefi, Mohammad, Avramis, Earl, Chmielowski, Bartosz, Friedman, Michael, Graeber, Thomas G, Lassen, Amanda, Le, Allison, Lomova, Anastasia, Ng, Charles, Ribas, Antoni, Titz, Bjoern, Tsoi, Jennifer   +11 more
core   +3 more sources

Cadmium induces testosterone synthesis disorder by testicular cell damage via TLR4/MAPK/NF-κB signaling pathway leading to reduced sexual behavior in piglets

Ecotoxicology and Environmental Safety, 2022
Cadmium (Cd) is a highly toxic metal pollutant that can endanger the life and health of animals. Toll-like receptor 4 (TLR4) can result in testicular cell damage by positively regulating mitogen-activated protein kinase (MAPK)/nuclear factor-kappaB (NF ...
Yulong Li, Yue Zhang, Rui Feng, Peng Zheng, He Huang, Sitong Zhou, Wenbo Ji, Fushuo Huang, Honggui Liu, Guixue Zhang   +9 more
doaj   +1 more source

Integration of a Phosphatase Cascade with the MAP Kinase Pathway provides for a Novel Signal Processing Function [PDF]

, 2009
We mathematically modeled the receptor-activated MAP kinase signaling by incorporating the regulation through cellular phosphatases. Activation induced the alignment of a phosphatase cascade in parallel with the MAP kinase pathway.
Alon, Altan-Bonnet, Bettini, Bhalla, Birtwistle, Blüthgen, Bollen, Brondello, Camps, Castelli, Chang, Cobb, Cyert, Das, Dickinson, Dickinson, Ebisuya, Echevarria, Eungdamrong, Ferrell, Friedman, Hatakeyama, Heinrich, Huang, Karlsson, Keyse, Kholodenko, Kolch, Kolch, Kumar, Kumar, Kurosaki, Kurosaki, Kurosaki, Kurosaki, Kurosaki, Levchenko, Locasale, Manders, Muda, Orton, Qiao, Raman, Reth, Rolli, Santos, Schmidt, Singh, Tan, Tian, Ueki, Widmann, Zandomeni, Zhao, Zi   +54 more
core   +3 more sources