Results 31 to 40 of about 303,295 (303)

Targeting Ras-ERK cascade by bioactive natural products for potential treatment of cancer: an updated overview

Cancer Cell International, 2022
MAPK (mitogen-activated protein kinase) or ERK (extracellular-signal-regulated kinase) pathway is an important link in the transition from extracellular signals to intracellular responses. Because of genetic and epigenetic changes, signaling cascades are
Eunus S. Ali, Shamima Akter, Sarker Ramproshad, Banani Mondal, Thoufiqul Alam Riaz, Muhammad Torequl Islam, Ishaq N. Khan, Anca Oana Docea, Daniela Calina, Javad Sharifi-Rad, William C. Cho   +10 more
doaj   +1 more source

Ecological inducers of the yeast filamentous growth pathway reveal environment-dependent roles for pathway components

mSphere, 2023
Signaling modules, such as mitogen-activated protein kinase (MAPK) pathways, are evolutionarily conserved drivers of cell differentiation and stress responses.
Matthew D. Vandermeulen, Paul J. Cullen
doaj   +1 more source

Dexamethasone-Induced Expression of Endothelial Mitogen-Activated Protein Kinase Phosphatase-1 Involves Activation of the Transcription Factors Activator Protein-1 and 3',5'-Cyclic Adenosine 5'-Monophosphate Response Element-Binding Protein and the Generation of Reactive Oxygen Species [PDF]

, 2008
We have recently identified the MAPK phosphatase (MKP)-1 as a novel mediator of the antiinflammatory properties of glucocorticoids (dexamethasone) in the human endothelium. However, nothing is as yet known about the signaling pathways responsible for the
Vollmar, Angelika M., Zahler, Stefan, Fürst, Robert   +2 more
core   +1 more source

The Protective Effect of Beraprost Sodium on Diabetic Nephropathy by Inhibiting Inflammation and p38 MAPK Signaling Pathway in High-Fat Diet/Streptozotocin-Induced Diabetic Rats

International Journal of Endocrinology, 2016
Background. p38 mitogen-activated protein kinase (MAPK) plays a crucial role in regulating signaling pathways implicated in inflammatory processes leading to diabetic nephropathy (DN).
Li Peng, Jie Li, Yixing Xu, Yangtian Wang, Hong Du, Jiaqing Shao, Zhimin Liu   +6 more
doaj   +1 more source

Structural Mechanism for the Specific Assembly and Activation of the Extracellular Signal Regulated Kinase 5 (ERK5) Module [PDF]

, 2013
Mitogen-activated protein kinase (MAPK) activation depends on a linear binding motif found in all MAPK kinases (MKK). In addition, the PB1 (Phox and Bem1) domain of MKK5 is required for extracellular signal regulated kinase 5 (ERK5) activation.
Remenyi, A, Attila Reményi, Glatz, G, Alexa, A, Glatz, Gábor, Gábor Glatz, Gogl, G, Alexa, Anita, Gógl, Gergő, Anita Alexa, Reményi, Attila, Gergő Gógl   +11 more
core   +1 more source

Mathematical model of the cell signaling pathway based on the extended Boolean network model with a stochastic process

BMC Bioinformatics, 2022
Background In cell signaling pathways, proteins interact with each other to determine cell fate in response to either cell-extrinsic (micro-environmental) or intrinsic cues.
Minsoo Kim, Eunjung Kim
doaj   +1 more source

Multiple Signals Converge on a Differentiation MAPK Pathway

PLoS Genetics, 2010
An important emerging question in the area of signal transduction is how information from different pathways becomes integrated into a highly coordinated response. In budding yeast, multiple pathways regulate filamentous growth, a complex differentiation response that occurs under specific environmental conditions.
Colin A Chavel, Heather M Dionne, Barbara Birkaya, Jyoti Joshi, Paul J Cullen   +4 more
openaire   +4 more sources

Cadmium induces testosterone synthesis disorder by testicular cell damage via TLR4/MAPK/NF-κB signaling pathway leading to reduced sexual behavior in piglets

Ecotoxicology and Environmental Safety, 2022
Cadmium (Cd) is a highly toxic metal pollutant that can endanger the life and health of animals. Toll-like receptor 4 (TLR4) can result in testicular cell damage by positively regulating mitogen-activated protein kinase (MAPK)/nuclear factor-kappaB (NF ...
Yulong Li, Yue Zhang, Rui Feng, Peng Zheng, He Huang, Sitong Zhou, Wenbo Ji, Fushuo Huang, Honggui Liu, Guixue Zhang   +9 more
doaj   +1 more source

PTPIP51 Crosslinks the NFκB Signaling and the MAPK Pathway in SKBR3 Cells [PDF]

Future Science OA, 2020
PTPIP51 interacts with NFκB signaling at the RelA and IκB level. NFκB signaling is linked to the initiation, progression and metastasis of breast cancer. Her2-amplified breast cancer cells frequently display activation of the NFκB signaling. We aimed to clarify the effects of NFκB inhibition on the NFκB- and MAPK-related interactome of PTPIP51 and cell
Dietel, Eric, Brobeil, Alexander, Tag, Claudia, Gattenlöhner, Stefan, Wimmer, Monika, Justus Liebig University Giessen   +5 more
openaire   +4 more sources

The role of p38 MAPK and its substrates in neuronal plasticity and neurodegenerative disease [PDF]

, 2012
A significant amount of evidence suggests that the p38-mitogen-activated protein kinase (MAPK) signalling cascade plays a crucial role in synaptic plasticity and in neurodegenerative diseases.
Eales, Katherine L., Corrêa, Sônia A. L.   +1 more
core   +1 more source