Results 51 to 60 of about 303,295 (303)

Inhibition of Mitogen-Activated Protein Kinase Erk1/2 Promotes Protein Degradation of ATP Binding Cassette Transporters A1 and G1 in CHO and in HuH7 cells.

, 2013
Signal transduction modulates expression and activity of cholesterol transporters. We recently demonstrated that the Ras/mitogen-activated protein kinase (MAPK) signaling cascade regulates protein stability of Scavenger Receptor BI (SR-BI) through ...
Enrich Bastús, Carles, Enrich Carlos, Karen Cecilia Chan, Monira Hoque, Darabi, Masoud, Reverter Martín, Meritxell, Hoque, Monira, Rentero Alfonso, Carles, Meritxell Reverter, Rentero Carles, Melanie Manetsch, Masoud Darabi, Mulay, Vishwaroop, Peta Wood, Grewal Thomas, Álvarez-Guaita, Anna, Heeren, Joerg, Anna Alvarez-Guaita, Kerry-Anne Rye, Darabi Masoud, Rye Kerry-Anne, Chan, Karen Cecilia, Manetsch, Melanie, Mulay Vishwaroop, Manetsch Melanie, Heeren Joerg, Carlos Enrich, Cairns, Rose, Reverter Meritxell, Joerg Heeren, Carles Rentero, Vishwaroop Mulay, Rose Cairns, Wood Peta, Wood, Peta, Grewal, Thomas, Rye, Kerry-Anne, Chan Karen Cecilia, Álvarez-Guaita Anna, Thomas Grewal, Hoque Monira, Cairns Rose   +41 more
core   +1 more source

RAS/MAPK signaling pathway [PDF]

, 2010
The RAS/MAPK pathway is a cell signaling pathway that plays a key role in regulation of cellular proliferation, apoptosis, cellular differenciation and migration and angiogenesis.
Pierre Laurent-Puig, Laurent-Puig, Pierre, Astrid Lièvre, Lièvre, Astrid   +3 more
core   +1 more source

MAPK signaling pathway-based glioma subtypes, machine-learning risk model, and key hub proteins identification

Scientific Reports, 2023
An early diagnosis and precise prognosis are critical for the treatment of glioma. The mitogen‑activated protein kinase (MAPK) signaling pathway potentially affects glioma, but the exploration of the clinical values of the pathway remains lacking.
Hengrui Liu, Tao Tang
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Regulation of MAPK Signaling Pathways by the Large HERC Ubiquitin Ligases

International Journal of Molecular Sciences, 2023
Protein ubiquitylation acts as a complex cell signaling mechanism since the formation of different mono- and polyubiquitin chains determines the substrate’s fate in the cell. E3 ligases define the specificity of this reaction by catalyzing the attachment of ubiquitin to the substrate protein.
Joan Sala-Gaston, Laura Costa-Sastre, Leonardo Pedrazza, Arturo Martinez-Martinez, Francesc Ventura, Jose Luis Rosa   +5 more
openaire   +3 more sources

Función del represor capicua en la Interpretación de señales RTK-Ras-MAPK en "Drosophila" [PDF]

, 2012
[spa] Las señales receptor tirosina kinasa (RTK) controlan un amplio abanico de decisiones durante el desarrollo de un animal, como la proliferación celular, diferenciación, morfogénesis y supervivencia.
Ajuria Astobiza, Leiore
core  

The molecular role of non-canonical Notch signaling via Deltex-1 in high grade glioma [PDF]

, 2011
Glioblastoma Multiforme is a WHO grade IV brain tumor with glial characteristics leading to more years of life lost than any other cancer. A better understanding of GBM biology and valid animal models are the two key elements to improved therapeutic ...
Huber, Roland Martin
core   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Implication of the MAPK Signalling Pathway in the Pathogenesis of Diabetic Nephropathy

EMJ Diabetes, 2019
Diabetes has become an emerging public health problem because of its serious complications, and high mortality and morbidity rates. Among the most common microvascular complications of diabetes is diabetic nephropathy (DN), which is a major cause of development of end-stage renal disease worldwide.
Jéssica Barletto Sousa Barros, Angela Adamski da Silva Reis, Rodrigo da Silva Santos   +2 more
openaire   +2 more sources

Wnt/ -Catenin and MAPK Signaling: Allies and Enemies in Different Battlefields [PDF]

, 2012
Two papers published in Science Signaling reveal extensive crosstalk between Wnt/-catenin and mitogen-activated protein kinase (MAPK) signaling in cancer.
Clevers, H., Guardavaccaro, D.
core   +1 more source