Results 51 to 60 of about 436,308 (305)

Structural Mechanism for the Specific Assembly and Activation of the Extracellular Signal Regulated Kinase 5 (ERK5) Module [PDF]

, 2013
Mitogen-activated protein kinase (MAPK) activation depends on a linear binding motif found in all MAPK kinases (MKK). In addition, the PB1 (Phox and Bem1) domain of MKK5 is required for extracellular signal regulated kinase 5 (ERK5) activation.
Aberg, Adams, Alexander, Bardwell, Barsyte-Lovejoy, Bhattacharyya, Bhattacharyya, Buschbeck, Caffrey, Cavanaugh, Chang, Chen, Coulombe, Drew, Emsley, Garai, Guo, Gupta, Gógl, Hayashi, Hu, Jacobs, Kabsch, Kato, Kato, Kondoh, Li, Liu, Liu, Liu, Ma, McCoy, Milanesi, Moscat, Murakami, Nakamura, Nakamura, Nakamura, Nishimoto, Pearson, Piserchio, Potthoff, Raman, Ranganathan, Regan, Reményi, Sharrocks, Sohn, Tanoue, Wang, Watson, Winn, Won, Zarrinpar, Zeke, Zhang, Zhou, Zhou   +57 more
core   +1 more source

Multiple Signals Converge on a Differentiation MAPK Pathway

PLoS Genetics, 2010
An important emerging question in the area of signal transduction is how information from different pathways becomes integrated into a highly coordinated response. In budding yeast, multiple pathways regulate filamentous growth, a complex differentiation response that occurs under specific environmental conditions.
Colin A Chavel, Heather M Dionne, Barbara Birkaya, Jyoti Joshi, Paul J Cullen   +4 more
openaire   +4 more sources

Dexamethasone inhibits repair of human airway epithelial cells mediated by glucocorticoid-induced leucine zipper (GILZ). [PDF]

PLoS ONE, 2013
BACKGROUND: Glucocorticoids (GCs) are a first-line treatment for asthma for their anti-inflammatory effects, but they also hinder the repair of airway epithelial injury.
Jingyue Liu, Mingxiang Zhang, Chao Niu, Zhengxiu Luo, Jihong Dai, Lijia Wang, Enmei Liu, Zhou Fu   +7 more
doaj   +1 more source

Both Hypoxia-Inducible Factor 1 and MAPK Signaling Pathway Attenuate PI3K/AKT via Suppression of Reactive Oxygen Species in Human Pluripotent Stem Cells

Frontiers in Cell and Developmental Biology, 2021
Mild hypoxia (5% O2) as well as FGFR1-induced activation of phosphatidylinositol-4,5-bisphosphate 3-kinase/protein kinase B (PI3K/AKT) and MAPK signaling pathways markedly support pluripotency in human pluripotent stem cells (hPSCs).
Petr Fojtík, Petr Fojtík, Deborah Beckerová, Deborah Beckerová, Katerina Holomková, Martin Šenfluk, Martin Šenfluk, Vladimir Rotrekl, Vladimir Rotrekl   +8 more
doaj   +1 more source

Mechanisms of sensorineural cell damage, death and survival in the cochlea. [PDF]

, 2015
The majority of acquired hearing loss, including presbycusis, is caused by irreversible damage to the sensorineural tissues of the cochlea. This article reviews the intracellular mechanisms that contribute to sensorineural damage in the cochlea, as well ...
Ryan, Allen F, Wong, Ann CY
core   +1 more source

Melanocortin potentiates leptin‐induced STAT3 signaling via MAPK pathway [PDF]

Journal of Neurochemistry, 2009
AbstractThe co‐existence of receptors for leptin and melanocortin in cerebral microvessels suggests possible interactions between leptin and α‐melanocyte stimulating hormone (MSH) signaling. In this study, we showed that ObRb and melanocortin receptor MC3R and MC4R were present in enriched cerebral microvessels.
Yan, Zhang, Xiaojun, Wu, Yi, He, Abba J, Kastin, Hung, Hsuchou, Charles I, Rosenblum, Weihong, Pan   +6 more
openaire   +2 more sources

MAPK signaling pathway-based glioma subtypes, machine-learning risk model, and key hub proteins identification

Scientific Reports, 2023
An early diagnosis and precise prognosis are critical for the treatment of glioma. The mitogen‑activated protein kinase (MAPK) signaling pathway potentially affects glioma, but the exploration of the clinical values of the pathway remains lacking.
Hengrui Liu, Tao Tang
doaj   +1 more source

Non-genomic actions of estradiol and 4-OH-tamoxifen on murine breast cancer cells [PDF]

, 2015
Estrogens and tamoxifen do not only exert their effects at the genomic level, but also play a role at the cell membrane activating downstream signaling pathways. We recently characterized an estrogen receptor-positive epithelial murine breast cancer cell
Bal, Elisa Dora, Pontiggia, Osvaldo Alejandro, Raffo, Diego Alejandro, Simian, Marina   +3 more
core   +2 more sources

Uniformly curated signaling pathways reveal tissue-specific cross-talks and support drug target discovery

, 2010
Motivation: Signaling pathways control a large variety of cellular processes. However, currently, even within the same database signaling pathways are often curated at different levels of detail.
Amberger, Bader, Bader, Bauer-Mehren, Becker, Behar, Berger, Berglund, Beyer, Bhattacharyya, Borisov, Boyle, Chaudhuri, Chen, Csaba Böde, Cusick, Davidov, Dennis, Drysdale, Dávid Fazekas, Fabbro, Frame, Freeman, Friedland, Gao, Harris, Hoffmann, Hopkins, Hornberg, Hunter, Illés J. Farkas, Joshi-Tope, Kandasamy, Katalin Lenti, Kholodenko, Klein, Komarova, Korcsmaros, Levine, Li, Liu, Lu, Luo, Morioka, Máté S. Szalay, O'Brien, Ogata, Papin, Petra Rovó, Pires-daSilva, Péter Csermely, Rhodes, Rogers, Sakharkar, Sergina, Stelling, Szathmary, Tamás Korcsmáros, Taniguchi, Tibor Vellai, Tortora, Urban, Wang, Xia, Yildirim, Zoltán Spiró   +65 more
core   +1 more source

Targeting Oncogenic BRAF: Past, Present, and Future. [PDF]

, 2019
Identifying recurrent somatic genetic alterations of, and dependency on, the kinase BRAF has enabled a "precision medicine" paradigm to diagnose and treat BRAF-driven tumors.
Bivona, Trever G, Wu, Wei, Zaman, Aubhishek   +2 more
core   +1 more source