Results 41 to 50 of about 303,295 (303)
Scientific Reports, 2021 Despite extensive research on molecular pathways controlling the process of regeneration in model organisms, little is known about the actual initiation signals necessary to induce regeneration. Recently, the activation of ERK signaling has been shown to
V. Jaenen +7 more
doaj +1 more source
eLife, 2017 Injury-induced (Wallerian) axonal degeneration is regulated via the opposing actions of pro-degenerative factors such as SARM1 and a MAPK signal and pro-survival factors, the most important of which is the NAD+ biosynthetic enzyme NMNAT2 that inhibits ...
Lauren J Walker +5 more
doaj +1 more source
Phorbol 12-Myristate 13-Acetate Induces MUC16 Expression via PKCδ and p38 in Human Airway Epithelial Cells [PDF]
Clinical and Experimental Otorhinolaryngology, 2012 ObjectivesPhorbol 12-myristate 13-acetate (PMA) is widely used as a protein kinase C (PKC) activator, PKC is involved in the secretion of mucins. MUC16, one of the membrane-bound mucins, is produced in human airway epithelial cells.
Chang Hoon Bae +3 more
doaj +1 more source
Functional dissection of the "Drosophila melanogaster" fibroblast growth factor signalling pathway in branching morphogenesis of the developing tracheal system [PDF]
, 2004 Fibroblast Growth Factor (FGF) signalling is involved in numerous developmental processes ranging from cell determination to mitogenesis, and cell survival to cell migration.
Dossenbach, Caroline
core +1 more source
MAPK/JNK signalling: a potential autophagy regulation pathway [PDF]
Bioscience Reports, 2015 Autophagy refers to a lysosomal degradative pathway or a process of self-cannibalization. This pathway maintains nutrients levels for vital cellular functions during periods of starvation and it provides cells with survival advantages under various stress situations.
Zhou, Yuan-Yuan +3 more
openaire +2 more sources
Modular modelling of signalling pathways and their crosstalk [PDF]
, 2012 Signalling pathways are well-known abstractions that explain the mechanisms whereby cells respond to signals. Collections of pathways form networks, and interactions between pathways in a network, known as cross-talk, enables further complex signalling ...
Calder, M. +3 more
core +1 more source
MAPKs in development: insights from Dictyostelium signaling pathways [PDF]
bmc, 2011 Abstract Mitogen activated protein kinases (MAPKs) play important roles in the development of eukaryotic organisms through the regulation of signal transduction pathways stimulated by external signals. MAPK signaling pathways have been associated with the regulation of cell growth, differentiation, and chemotaxis,
Hadwiger Jeffrey A., Nguyen Hoai-Nghia
openaire +3 more sources
Version control of pathway models using XML patches [PDF]
, 2009 <p>Background: Computational modelling has become an important tool in understanding biological systems such as signalling pathways. With an increase in size complexity of models comes a need for techniques to manage model versions and their ...
Orton, R. +3 more
core +1 more source
Frontiers in Cell and Developmental Biology, 2021 Mild hypoxia (5% O2) as well as FGFR1-induced activation of phosphatidylinositol-4,5-bisphosphate 3-kinase/protein kinase B (PI3K/AKT) and MAPK signaling pathways markedly support pluripotency in human pluripotent stem cells (hPSCs).
Petr Fojtík +8 more
doaj +1 more source
Dexamethasone inhibits repair of human airway epithelial cells mediated by glucocorticoid-induced leucine zipper (GILZ). [PDF]
PLoS ONE, 2013 BACKGROUND: Glucocorticoids (GCs) are a first-line treatment for asthma for their anti-inflammatory effects, but they also hinder the repair of airway epithelial injury.
Jingyue Liu +7 more
doaj +1 more source