Results 21 to 30 of about 288,292 (262)

The ARM repeat domain of hemocyanin interacts with MKK4 to modulate antimicrobial peptides expression

iScience, 2022
Summary: The mitogen-activated protein kinase (MAPK) intracellular signaling pathway mediates numerous biological processes, including antimicrobial immune response by inducing antimicrobial peptides (AMPs) production.
Jude Juventus Aweya, Kaiying Zhuang, Yiqi Liu, Jiaohong Fan, Defu Yao, Fan Wang, Xiaohan Chen, Shengkang Li, Hongyu Ma, Yueling Zhang   +9 more
doaj   +1 more source

Treadmill Running Improves Spatial Learning Memory Through Inactivation of Nuclear Factor Kappa B/Mitogen-Activated Protein Kinase Signaling Pathway in Amyloid-β-Induced Alzheimer Disease Rats [PDF]

International Neurourology Journal, 2021
Purpose Exercise is known to reduce proinflammatory cytokines production and apoptosis. We investigated the effect of treadmill running on spatial learning memory in terms of activation of nuclear factor kappa B (NF-κB) and mitogen-activated protein ...
Sang-Hoon Kim, Young Jun Ko, Jee-Youn Kim, Young-Je Sim   +3 more
doaj   +1 more source

The expression of MAPK signaling pathways in conjunctivochalasis

International Journal of Ophthalmology, 2019
This study investigated the potential role of MAPK signaling pathways in conjunctivochalasis (CCH). Twenty loose conjunctival biopsy samples from 20 CCH and 15 conjunctival biopsy samples from 15 normal controls (CON) were collected. The conjunctival fibroblasts were cultured in vitro.
Yuan-Ling Jia, Xiao-Jing Liu, Hang Wen, Yue-Ping Zhan, Min-Hong Xiang   +4 more
openaire   +3 more sources

Gene Expression Profiling Identifies Downregulation of the Neurotrophin-MAPK Signaling Pathway in Female Diabetic Peripheral Neuropathy Patients

Journal of Diabetes Research, 2017
Diabetic peripheral neuropathy (DPN) is a common complication of diabetes mellitus (DM). It is not diagnosed or managed properly in the majority of patients because its pathogenesis remains controversial.
Lin Luo, Wen-Hua Zhou, Jiang-Jia Cai, Mei Feng, Mi Zhou, Su-Pei Hu, Jin Xu, Lin-Dan Ji   +7 more
doaj   +1 more source

Targeting Ras-ERK cascade by bioactive natural products for potential treatment of cancer: an updated overview

Cancer Cell International, 2022
MAPK (mitogen-activated protein kinase) or ERK (extracellular-signal-regulated kinase) pathway is an important link in the transition from extracellular signals to intracellular responses. Because of genetic and epigenetic changes, signaling cascades are
Eunus S. Ali, Shamima Akter, Sarker Ramproshad, Banani Mondal, Thoufiqul Alam Riaz, Muhammad Torequl Islam, Ishaq N. Khan, Anca Oana Docea, Daniela Calina, Javad Sharifi-Rad, William C. Cho   +10 more
doaj   +1 more source

The Protective Effect of Beraprost Sodium on Diabetic Nephropathy by Inhibiting Inflammation and p38 MAPK Signaling Pathway in High-Fat Diet/Streptozotocin-Induced Diabetic Rats

International Journal of Endocrinology, 2016
Background. p38 mitogen-activated protein kinase (MAPK) plays a crucial role in regulating signaling pathways implicated in inflammatory processes leading to diabetic nephropathy (DN).
Li Peng, Jie Li, Yixing Xu, Yangtian Wang, Hong Du, Jiaqing Shao, Zhimin Liu   +6 more
doaj   +1 more source

Ecological inducers of the yeast filamentous growth pathway reveal environment-dependent roles for pathway components

mSphere, 2023
Signaling modules, such as mitogen-activated protein kinase (MAPK) pathways, are evolutionarily conserved drivers of cell differentiation and stress responses.
Matthew D. Vandermeulen, Paul J. Cullen
doaj   +1 more source

Mathematical model of the cell signaling pathway based on the extended Boolean network model with a stochastic process

BMC Bioinformatics, 2022
Background In cell signaling pathways, proteins interact with each other to determine cell fate in response to either cell-extrinsic (micro-environmental) or intrinsic cues.
Minsoo Kim, Eunjung Kim
doaj   +1 more source

Cadmium induces testosterone synthesis disorder by testicular cell damage via TLR4/MAPK/NF-κB signaling pathway leading to reduced sexual behavior in piglets

Ecotoxicology and Environmental Safety, 2022
Cadmium (Cd) is a highly toxic metal pollutant that can endanger the life and health of animals. Toll-like receptor 4 (TLR4) can result in testicular cell damage by positively regulating mitogen-activated protein kinase (MAPK)/nuclear factor-kappaB (NF ...
Yulong Li, Yue Zhang, Rui Feng, Peng Zheng, He Huang, Sitong Zhou, Wenbo Ji, Fushuo Huang, Honggui Liu, Guixue Zhang   +9 more
doaj   +1 more source

Multiple Signals Converge on a Differentiation MAPK Pathway

PLoS Genetics, 2010
An important emerging question in the area of signal transduction is how information from different pathways becomes integrated into a highly coordinated response. In budding yeast, multiple pathways regulate filamentous growth, a complex differentiation response that occurs under specific environmental conditions.
Colin A Chavel, Heather M Dionne, Barbara Birkaya, Jyoti Joshi, Paul J Cullen   +4 more
openaire   +4 more sources