Results 11 to 20 of about 303,295 (303)
Astragaloside IV Ameliorates Myocardial Infarction Induced Apoptosis and Restores Cardiac Function
Frontiers in Cell and Developmental Biology, 2021 BackgroundType 2 diabetes mellitus increases the risk of cardiovascular disease including myocardial infarction (MI). Inflammation and apoptosis have been implicated in the pathophysiology of MI.
Chuang Sun +8 more
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MAPK pathway: Potential role in glioblastoma multiforme
Interdisciplinary Neurosurgery, 2021 Glioblastoma multiforme (GBM) is one of the most aggressive and damaging tumors of the brain. For successful therapy of GBM exact pathways need to be explored for developing effective targeted chemotherapeutic agents.
Kowthavarapu V. Krishna +4 more
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MAPK pathway activation selectively inhibits ASCL1-driven small cell lung cancer
iScience, 2021 Summary: Activation of mitogenic signaling pathways is a common oncogenic driver of many solid tumors including lung cancer. Although activating mutations in the mitogen-activated protein kinase (MAPK) pathway are prevalent in non-small cell lung cancers,
Rebecca Caeser +15 more
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Endothelial-derived APT1-mediated macrophage-endothelial cell interactions participate in the development of atherosclerosis by regulating the Ras/MAPK signaling pathway [PDF]
, 2022 Acyl-protein thioesterase 1 (APT1) can affect H-Ras localization and function by promoting its depalmitoylation. However, relatively little attention has been paid to the effects of APT1 on H-Ras in the cardiovascular system.
Tse, Gary +6 more
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The Complex Role of MAPK/ERK Signaling Pathway in Different Types of Thrombocytopenia
Current Issues in Molecular BiologyThrombocytopenia is a common hematological disorder caused by a variety of factors. It often complicates diseases and treatment options for this condition are quite limited. There are no approved drugs for certain types of thrombocytopenia.
Peipei Xue, Maoshan Chen
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Poultry Science, 2023 : Quercetin (Que), widely found in a huge variety of plants, plays important roles in ovarian function. However, to data, there have been no reports about Que regulating granulosa cells (GCs) in prehierarchical follicles in chicken.
Manman Shen +7 more
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Cell Communication and Signaling, 2023 Background Ovarian cancer, particularly epithelial ovarian cancer (EOC), is the leading cause of cancer-related mortality among women. Our previous study revealed that high HMGB3 levels are associated with poor prognosis and lymph node metastasis in ...
Hanlin Ma +5 more
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A MAPK pathway mediates ethylene signaling in plants [PDF]
The EMBO Journal, 2003 Ethylene signal transduction involves ETR1, a two-component histidine protein kinase receptor. ETR1 functions upstream of the negative regulator CTR1. The similarity of CTR1 to members of the Raf family of mitogen-activated protein kinase kinase kinases (MAPKKKs) suggested that ethylene signaling in plants involves a MAPK pathway, but no direct ...
Ouaked, Fatma +3 more
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Adiponectin impairs chicken preadipocytes differentiation through p38 MAPK/ATF-2 and TOR/p70 S6 kinase pathways. [PDF]
PLoS ONE, 2013 Adiponectin is a protein hormone secreted exclusively by adipocytes that plays an important role in the modulation of glucose and lipid metabolism.
Jun Yan, Lu Gan, Di Chen, Chao Sun
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ERK/MAPK signalling pathway and tumorigenesis.
Experimental and therapeutic medicine, 2020 Mitogen-activated protein kinase (MAPK) cascades are key signalling pathways that regulate a wide variety of cellular processes, including proliferation, differentiation, apoptosis and stress responses. The MAPK pathway includes three main kinases, MAPK kinase kinase, MAPK kinase and MAPK, which activate and phosphorylate downstream proteins.
Guo, Yan-Jun +5 more
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