Results 11 to 20 of about 288,292 (262)
Organophosphorus Compounds and MAPK Signaling Pathways [PDF]
International Journal of Molecular Sciences, 2020 The molecular signaling pathways that lead to cell survival/death after exposure to organophosphate compounds (OPCs) are not yet fully understood. Mitogen-activated protein kinases (MAPKs) including the extracellular signal-regulated protein kinase (ERK), the c-Jun NH2-terminal kinase (JNK), and the p38-MAPK play the leading roles in the transmission ...
Tahereh Farkhondeh +5 more
openaire +3 more sources
The Role of PI3K/AKT and MAPK Signaling Pathways in Erythropoietin Signalization [PDF]
International Journal of Molecular Sciences, 2021 Erythropoietin (EPO) is a glycoprotein cytokine known for its pleiotropic effects on various types of cells and tissues. EPO and its receptor EPOR trigger signaling cascades JAK2/STAT5, MAPK, and PI3K/AKT that are interconnected and irreplaceable for cell survival. In this article, we describe the role of the MAPK and PI3K/AKT signaling pathways during
Zuzana Tóthová +5 more
openaire +3 more sources
The roles of MAPK signaling pathway in ovarian folliculogenesis. [PDF]
J Ovarian ResAbstract Ovarian folliculogenesis is a complex biological process critical for female fertility, intricately regulated by various signaling pathways, among which the Mitogen-Activated Protein Kinase (MAPK) signaling pathway plays a pivotal role.
Zhao H, Dinh TH, Wang Y, Yang Y.
europepmc +3 more sources
Understanding MAPK Signaling Pathways in Apoptosis [PDF]
International Journal of Molecular Sciences, 2020 MAPK (mitogen-activated protein kinase) signaling pathways regulate a variety of biological processes through multiple cellular mechanisms. In most of these processes, such as apoptosis, MAPKs have a dual role since they can act as activators or inhibitors, depending on the cell type and the stimulus.
Yue, Jicheng, López, José M.
openaire +2 more sources
Cell Communication and Signaling, 2023 Background Ovarian cancer, particularly epithelial ovarian cancer (EOC), is the leading cause of cancer-related mortality among women. Our previous study revealed that high HMGB3 levels are associated with poor prognosis and lymph node metastasis in ...
Hanlin Ma +5 more
doaj +1 more source
A MAPK pathway mediates ethylene signaling in plants [PDF]
The EMBO Journal, 2003 Ethylene signal transduction involves ETR1, a two-component histidine protein kinase receptor. ETR1 functions upstream of the negative regulator CTR1. The similarity of CTR1 to members of the Raf family of mitogen-activated protein kinase kinase kinases (MAPKKKs) suggested that ethylene signaling in plants involves a MAPK pathway, but no direct ...
Ouaked, Fatma +3 more
openaire +4 more sources
ERK/MAPK signalling pathway and tumorigenesis.
Experimental and therapeutic medicine, 2020 Mitogen-activated protein kinase (MAPK) cascades are key signalling pathways that regulate a wide variety of cellular processes, including proliferation, differentiation, apoptosis and stress responses. The MAPK pathway includes three main kinases, MAPK kinase kinase, MAPK kinase and MAPK, which activate and phosphorylate downstream proteins.
Guo, Yan-Jun +5 more
openaire +4 more sources
Opioid-induced mitogen-activated protein kinase signaling in rat enteric neurons following chronic morphine treatment. [PDF]
PLoS ONE, 2014 Opioids, acting at μ opioid receptors, are commonly used for pain management. Chronic opioid treatment induces cellular adaptations, which trigger long-term side effects, including constipation mediated by enteric neurons.
Celine Duraffourd +4 more
doaj +1 more source
MAPK Signaling Pathways in Hepatic Ischemia/Reperfusion Injury
Journal of Inflammation Research, 2023 The mitogen-activated protein kinase signaling pathway can be activated by a variety of growth factors, cytokines, and hormones, and mediates numerous intracellular signals related to cellular activities, including cell proliferation, motility, and differentiation.
Yu,Bo +7 more
openaire +4 more sources
Effect of Basigin on the Mitogen Activated Protein Kinase Signaling Pathway and Apoptosis in Qinchuan Cattle Muscle during Postmortem Maturation [PDF]
Shipin KexueIn order to explore the effects of basigin (BSG) on the mitogen activated protein kinase (MAPK) signaling pathway and apoptosis in Qinchuan cattle muscle during postmortem maturation, the changes in BSG and related differentially expressed proteins were ...
SU Xiaofeng, LI Yalei, LUO Ruiming
doaj +1 more source