Results 71 to 80 of about 1,569,209 (311)

Pathway of PPAR signaling pathway. [PDF]

, 2015
Pathway of PPAR signaling pathway.
Liqiao Chen (322720), Erchao Li (322712), Chang Xu (102022), Ke Chen (73307), Zhixin Xu (786989), Jian G. Qin (314167), Tongyu Li (765430)   +6 more
core   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Core Notch-Delta signaling pathway. [PDF]

, 2014
Core Notch-Delta signaling pathway.
Joseph M. Mahaffy (580601), Jerry S. Chen (580598), Robert W. Zeller (580600), Abygail M. Gumbayan (580599)   +3 more
core   +1 more source

AGE-RAGE signaling pathway in diabetic complications. [PDF]

, 2023
AGE-RAGE signaling pathway in diabetic complications.
Tao Han (22342), Jiqin Tang (14328980), Guoxiu Zu (14328977), Yangyang Wang (642852), Chengdong Zhang (259234), Ying Yu (7066)   +5 more
core   +1 more source

Inhibition of H3K9me2 Reduces Hair Cell Regeneration after Hair Cell Loss in the Zebrafish Lateral Line by Down-Regulating the Wnt and Fgf Signaling Pathways

Frontiers in Molecular Neuroscience, 2016
The activation of neuromast supporting cell (SC) proliferation leads to hair cell (HC) regeneration in the zebrafish lateral line. Epigenetic mechanisms have been reported that regulate HC regeneration in the zebrafish lateral line, but the role of ...
Dongmei eTang, Qin eLin, Yingzi eHe, Renjie eChai, Renjie eChai, Huawei eLi, Huawei eLi, Huawei eLi, Huawei eLi   +8 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

The extended CovR signaling pathway in BM110. [PDF]

, 2021
The extended CovR signaling pathway in BM110.
Maria-Vittoria Mazzuoli (5105312), Claudia Chica (65836), Philippe Glaser (380391), Maëlle Daunesse (11402633), Myriam Gominet (58093), Arnaud Firon (132290), Rachel Legendre (4596208), Pierre Alexandre Kaminski (486818), Hugo Varet (816197), Odile Sismeiro (12747), Patrick Trieu-Cuot (137125), Isabelle Rosinski-Chupin (246239)   +11 more
core   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

HIPPO Signaling Pathway. [PDF]

, 2017
Components of HIPPO signaling pathway. Magenta circles represent genes/gene products mutated in NF1 tumors. 14-3-3 protein is encoded by SFN gene.
Joseph DeRisi (30467), Daniel L. Faden (145807), Michel Kliot (3666415), Saurabh Asthana (40199), Tarik Tihan (3666412)   +4 more
core   +1 more source

Multi-omics analysis reveals the mechanism of verbenalin in treating gout via modulating purine metabolism, gut microbiota, and inflammatory pathways

Frontiers in Immunology
BackgroundGout is a prevalent metabolic disorder characterized by hyperuricemia and inflammation. Verbenalin, an iridoid glycoside from Verbena officinalis, possesses anti-inflammatory properties; however, its therapeutic potential and underlying ...
Yan Xiao, Yan Xiao, Ting Zhang, Ting Zhang, Qianglong Chen, Qianglong Chen, Yiqian Zhang, Bingyan Chen, Bingyan Chen, Meiling Wang, Meiling Wang, Yingjie Zhang, Yingjie Zhang, Mingqing Huang, Youxin Su, Jiemei Guo, Jiemei Guo   +16 more
doaj   +1 more source