Results 91 to 100 of about 1,569,209 (311)

The pathways enriched in the MAPK signaling pathway (A), apoptosis pathway (B) and hippocampal signaling pathway (C). [PDF]

, 2015
The pathways enriched in the MAPK signaling pathway (A), apoptosis pathway (B) and hippocampal signaling pathway (C).
Zhen Chen (129176), Weihan Qin (737342), Donghua Zou (290402), Xixia Liu (737341), Yuan Wu (299363), Qi Huang (148030)   +5 more
core   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Activation of the Canonical Wnt Signaling Pathway Induces Cementum Regeneration [PDF]

, 2014
Canonical Wnt signaling is important in tooth development but it is unclear whether it can induce cementogenesis and promote the regeneration of periodontal tissues lost because of disease. Therefore, the aim of this study is to investigate the influence
Han, Pingping, Crawford, Ross, Xiao, Yin, Ivanovski, Saso   +3 more
core   +1 more source

Purinosomes involved in the regulation of tumor metabolism: current progress and potential application targets

Frontiers in Oncology
The core of tumor cell metabolism is the management of energy metabolism due to the extremely high energy requirements of tumor cells. The purine nucleotide synthesis pathway in cells uses the purinosomes as an essential spatial structural complex.
Jiaqi Xie, Jiaqi Xie, Jiaqi Liu, Jiaqi Liu, Xiehui Chen, Changchun Zeng   +5 more
doaj   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Retroactive Signaling in Short Signaling Pathways

PLoS ONE, 2012
في مسارات الإشارات الكيميائية الحيوية دون وصلات تغذية مرتدة صريحة، عادة ما يوصف نقل الإشارة الأساسية بأنه اتصال أحادي الاتجاه، ينتقل من المنبع إلى المصب في سلسلة تغذية أمامية أو شبكة من دورات التعديل التساهمية. في هذه الورقة، نستكشف إمكانية وجود نوع جديد من الإشارات يسمى الإشارات بأثر رجعي، والتي توفرها الخاصية التي تم إظهارها مؤخرًا للأثر الرجعي في ...
Jacques Alexandre Sepulchre, Sofía D. Merajver, Alejandra C. Ventura   +2 more
openaire   +5 more sources

EEF1D overexpression promotes osteosarcoma cell proliferation by facilitating Akt-mTOR and Akt-bad signaling

Journal of Experimental & Clinical Cancer Research, 2018
Background Dysregulation of eukaryotic translation elongation factor 1 delta (EEF1D) in cancers has been reported; however, the role and mechanisms of EEF1D in osteosarcoma remain poorly understood.
Dong-dong Cheng, Shi-jie Li, Bin Zhu, Shu-min Zhou, Qing-cheng Yang   +4 more
doaj   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Signaling pathways in elastic tissues

Cellular Signalling, 2019
For many years elastin was considered as the matrix component structurally required to provide tissue elasticity. However, the expanded knowledge on the regulation of connective tissue homeostasis has revealed that elastic fibers also represent a source of elastokines and are the target of a number of signaling pathways mainly involving the TGF-β/BMP ...
Willeke F. Daamen, Daniela Quaglino
openaire   +5 more sources

Focus on the cGAS-STING Signaling Pathway in Sepsis and Its Inflammatory Regulatory Effects [PDF]

Yupeng Han,1,2,* Liangcheng Qiu,1,2,* Haixing Wu,1,2,* Zhiwei Song,3 Peng Ke,1,2 Xiaodan Wu1,2 1Department of Anesthesiology, Fujian Provincial Hospital, Shengli Clinical Medical College of Fujian Medical University, Fuzhou, Fujian, People’s ...
Ke P, Han Y, Song Z, Qiu L, Wu H, Wu X
core   +1 more source