Results 101 to 110 of about 1,526,064 (264)
Retroactive Signaling in Short Signaling Pathways
PLoS ONE, 2012 في مسارات الإشارات الكيميائية الحيوية دون وصلات تغذية مرتدة صريحة، عادة ما يوصف نقل الإشارة الأساسية بأنه اتصال أحادي الاتجاه، ينتقل من المنبع إلى المصب في سلسلة تغذية أمامية أو شبكة من دورات التعديل التساهمية. في هذه الورقة، نستكشف إمكانية وجود نوع جديد من الإشارات يسمى الإشارات بأثر رجعي، والتي توفرها الخاصية التي تم إظهارها مؤخرًا للأثر الرجعي في ...
Jacques Alexandre Sepulchre +2 more
openaire +5 more sources
FEBS Letters, EarlyView.Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai +4 more
wiley +1 more source
Signaling pathways in elastic tissues
Cellular Signalling, 2019 For many years elastin was considered as the matrix component structurally required to provide tissue elasticity. However, the expanded knowledge on the regulation of connective tissue homeostasis has revealed that elastic fibers also represent a source of elastokines and are the target of a number of signaling pathways mainly involving the TGF-β/BMP ...
Willeke F. Daamen, Daniela Quaglino
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Frizzled Proteins are bona fide G Protein-Coupled Receptors [PDF]
, 2009 Receptors of the Frizzled family initiate Wnt ligand-dependent signaling controlling multiple steps in organism development and highly conserved in evolution. Misactivation of the Wnt/Frizzled signaling is cancerogenic.
Silke Buestorf, Vladimir L. Katanaev
core
Endothelial Wnt/β-catenin signaling inhibits glioma angiogenesis and normalizes tumor blood vessels by inducing PDGF-B expression [PDF]
, 2012 Endothelial Wnt/β-catenin signaling is necessary for angiogenesis of the central nervous system and blood–brain barrier (BBB) differentiation, but its relevance for glioma vascularization is unknown. In this study, we show that doxycycline-dependent Wnt1
Devraj, Kavi +29 more
core +1 more source
Gene Expression Network Analysis Identifies Potential Targets for Prevention of Preeclampsia
International Journal of General Medicine, 2022 Yu Xia,1– 3 Yu-Dong Zhao,4 Gui-Xiang Sun,1,2 Shuai-Shuai Xia,1 Zheng-Wang Yang3 1Provincial Key Laboratory of TCM Diagnostics, Hunan University of Chinese Medicine, Changsha, Hunan Province, 410208, People’s Republic of China; 2Institute of Chinese ...
Xia Y, Zhao YD, Sun GX, Xia SS, Yang ZW
doaj
FEBS Letters, EarlyView.This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley +1 more source
Characterization of a gp130 Signaling Receptor Polymorphism [PDF]
, 2013 We previously reported an association between human herpesvirus 8 (HHV-8) seroprevalence and increased prostate cancer risk among men on the Caribbean island of Tobago.
Kercher, Katherine
core
Frontiers in Molecular Neuroscience, 2016 The activation of neuromast supporting cell (SC) proliferation leads to hair cell (HC) regeneration in the zebrafish lateral line. Epigenetic mechanisms have been reported that regulate HC regeneration in the zebrafish lateral line, but the role of ...
Dongmei eTang +8 more
doaj +1 more source
FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source