Results 111 to 120 of about 1,569,209 (311)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

open access: yesFEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Notch Signaling Pathway Interfering as a Possible Asthma Treatment: A Narrative Review [PDF]

open access: yes
Jingya Wang,1,2,* Kang Yan,3,* Leilei Ma,1,4,* Xianglei Yan,1 Zihan Meng,1 Ji-an Li,1 Meng Wang,1 Chenguang Du,1 Yueyue Yu1 1College of Traditional Chinese Medicine, North China University of Technology, Tangshan, Hebei, People’s Republic of ...
Wang M   +8 more
core   +1 more source

Workflow for signaling pathway-based strategy. [PDF]

open access: yes, 2015
Workflow for signaling pathway-based strategy.
Jianling Liu (716043)   +8 more
core   +1 more source

Gene Expression Network Analysis Identifies Potential Targets for Prevention of Preeclampsia

open access: yesInternational Journal of General Medicine, 2022
Yu Xia,1– 3 Yu-Dong Zhao,4 Gui-Xiang Sun,1,2 Shuai-Shuai Xia,1 Zheng-Wang Yang3 1Provincial Key Laboratory of TCM Diagnostics, Hunan University of Chinese Medicine, Changsha, Hunan Province, 410208, People’s Republic of China; 2Institute of Chinese ...
Xia Y, Zhao YD, Sun GX, Xia SS, Yang ZW
doaj  

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

open access: yesFEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa   +2 more
wiley   +1 more source

The genes of the TLR signaling pathway. [PDF]

open access: yes, 2012
The genes of the TLR signaling pathway.
Ping Jin (30857)   +4 more
core   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

open access: yesFEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry   +9 more
wiley   +1 more source

IL-6 signaling pathway in bladder cancer. [PDF]

open access: yes, 2013
IL-6 signaling pathway in bladder cancer.
Miao-Fen Chen (13424)   +4 more
core   +1 more source

Baicalin restore intestinal damage after early-life antibiotic therapy: the role of the MAPK signaling pathway

open access: yesPharmacological Research
Antibiotic related intestinal injury in early life affects subsequent health and susceptibility. Here, we employed weaned piglets as a model to investigate the protective effects of baicalin against early-life antibiotic exposure-induced microbial ...
Shunfen Zhang   +7 more
doaj   +1 more source

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

open access: yesFEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara   +3 more
wiley   +1 more source

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