Results 81 to 90 of about 1,569,209 (311)

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

The involvement of exosomes in the tumorigenicity of breast cancer cell lines through the crosstalk between STAT3, Notch, and Wnt signaling pathways

Discover Oncology
Background Exosomes play a critical role in the tumor microenvironment by interacting with signaling pathways that facilitate breast cancer metastasis, particularly the STAT3 pathway.
Shymaa Abdullah Mohamed, Toka M. I. Badawy, Menna Allah M. K. Hussein, Mohammed Salama, Yasser M. El Kerm, Mohamed A. Abdel Mohsen   +5 more
doaj   +1 more source

Lngfr Promotes Osteogenic Differentiation Of Emscs

International Dental Journal
Aim or purpose: This study aims to investigate the influence of LNGFR on the osteogenesis of EMSCs and elucidate the potential biological mechanism. Materials and methods: EMSCs were isolated from embryonic facial processes from an embryonic 16.5-day ...
Keyu Wang, Xin Nie
doaj   +1 more source

Gene Expression Profiling Identifies Downregulation of the Neurotrophin-MAPK Signaling Pathway in Female Diabetic Peripheral Neuropathy Patients

Journal of Diabetes Research, 2017
Diabetic peripheral neuropathy (DPN) is a common complication of diabetes mellitus (DM). It is not diagnosed or managed properly in the majority of patients because its pathogenesis remains controversial.
Lin Luo, Wen-Hua Zhou, Jiang-Jia Cai, Mei Feng, Mi Zhou, Su-Pei Hu, Jin Xu, Lin-Dan Ji   +7 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

The protective effect of naringenin on ulcerative colitis in mice through increasing Nrf2 pathway activity

Acta Biochimica et Biophysica Sinica
Ulcerative colitis (UC) is a chronic inflammatory disease with an increasing prevalence worldwide. Naringenin (NAR) has been proven effective in preventing UC, but its mechanism has not been fully elucidated.
Li Jiaxiang, Hua Li, Hu Meichun, Zhu Ni, Dong Sijin, Jing Xiaoli, Zhu Zihuan, Liu Yifei, Zhou Yanhong   +8 more
doaj   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Putative significantly differential expressed molecules and genes enriched to Jak-STAT signaling pathway and NOD-like signaling pathway. [PDF]

, 2016
Putative significantly differential expressed molecules and genes enriched to Jak-STAT signaling pathway and NOD-like signaling pathway.
Huabin Cao (2824973), Caiying Zhang (2824976), Fei Yang (46361), Yu Zhuang (2824982), Xiaoquan Guo (2824988), Yalu Song (2824991), Tiancheng Wang (2406016), Ping Liu (156158), Huayuan Lin (2824985), Guoliang Hu (2824979), Qingyang Xiao (686993)   +10 more
core   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Effect of Cell Growth and Proliferation Factors (EGF/PDGF Signaling Pathway) on the Etiopathogenesis of Intrauterine Growth Restriction [PDF]

Objective: It is likely that the subgroups of the epidermal growth factor/platelet-derived growth factor (EGF/PDGF) signaling pathway play a role in the etiopathogenesis of intrauterine growth restriction (IUGR).
Erhan Demirdağ, Emin Ümit Bağrıacık, Serhan Can İşcan, Merih Bayram, Melek Yaman   +4 more
core   +1 more source