Results 1 to 10 of about 78,062 (117)

Targeting Nrf2/KEAP1 signaling pathway using bioactive compounds to combat mastitis

Frontiers in Immunology
Mastitis is a common inflammation of mammary glands that has a significantly impact on dairy production and animal health, causing considerable economic burdens worldwide.
Muhammad Zahoor Khan, Liangliang Li, Yandong Zhan, Huang Binjiang, Xiaotong Liu, Xiyan Kou, Adnan Khan, Abdul Qadeer, Qudrat Ullah, Khalid J. Alzahrani, Tongtong Wang, Changfa Wang, Muhammad Zahoor   +12 more
doaj   +3 more sources

Isoliquiritigenin as a modulator of the Nrf2 signaling pathway: potential therapeutic implications [PDF]

Frontiers in Pharmacology
Nuclear factor erythroid-2-related factor 2 (Nrf2), a transcription factor responsible for cytoprotection, plays a crucial role in regulating the expression of numerous antioxidant genes, thereby reducing reactive oxygen species (ROS) levels and ...
Mangmang Qiu, Kang Ma, Junfeng Zhang, Zhaohua Zhao, Shan Wang, Qing Wang, Hao Xu   +6 more
doaj   +2 more sources

The role of Nrf2 signaling pathway in diabetic cardiomyopathy: from pathogenesis to traditional Chinese medicine interventions [PDF]

Frontiers in Cardiovascular Medicine
Diabetic cardiomyopathy (DCM), a common diabetic complication independent of hypertension, coronary heart disease and heart valve disease is a major cause of cardiovascular mortality. The pathogenesis of DCM is complex. The Nrf2-related signaling pathway
Huixian Gu, Junchang Liu, Jie Jiang, Hongyan Ma, Siyu Wu, Longfei Sun, Longfei Sun, Lan Yao, Lan Yao   +8 more
doaj   +2 more sources

Interaction of saffron and its constituents with Nrf2 signaling pathway: A review [PDF]

Iranian Journal of Basic Medical Sciences, 2022
Saffron (Crocus sativus) is a natural compound and its constituents such as crocin, crocetin, and safranal have many pharmacological properties such as anti-oxidant, anti-inflammatory, antitumor, antigenotoxic, anti-depressant, hepatoprotective ...
Arian Khoshandam, Bibi Marjan Razavi, Hossein Hosseinzadeh   +2 more
doaj   +1 more source

Activation of Nrf2 in Astrocytes Suppressed PD-Like Phenotypes via Antioxidant and Autophagy Pathways in Rat and Drosophila Models

Cells, 2021
The oxidative-stress-induced impairment of autophagy plays a critical role in the pathogenesis of Parkinson’s disease (PD). In this study, we investigated whether the alteration of Nrf2 in astrocytes protected against 6-OHDA (6-hydroxydopamine)- and ...
Qing Guo, Bing Wang, Xiaobo Wang, Wanli W. Smith, Yi Zhu, Zhaohui Liu   +5 more
doaj   +1 more source

Recent Advances in the Role of Nuclear Factor Erythroid-2-Related Factor 2 in Spinal Cord Injury: Regulatory Mechanisms and Therapeutic Options

Frontiers in Aging Neuroscience, 2022
Nuclear factor erythroid-2-related factor 2 (Nrf2) is a pleiotropic transcription factor, and it has been documented that it can induce defense mechanisms both oxidative stress and inflammatory injury.
Tianqi Jiang, Tianqi Jiang, Yongxiong He
doaj   +1 more source

H₂O₂/DEM-Promoted Maft Promoter Demethylation Drives Nrf2/ARE Activation in Zebrafish

Life, 2022
The Nrf2/ARE signaling pathway is a cell survival response pathway in response to environmental stresses. The Nrf2/ARE signaling pathway can be activated by stimulating cysteine residues at different positions in the Keap1.
Ce Chen, Mingyue He, Xueting Li, Lidong Yu, Yi Liu, Yan Yang, Li Li, Jianbo Jia, Bingsheng Li   +8 more
doaj   +1 more source

Keap1/Nrf2 Signaling Pathway

Antioxidants, 2021
Nuclear factor, erythroid 2-like transcription factor 2 (Nrf2) and its cytoplasmic inhibitor, kelch-like ECH-associated protein 1 (Keap1), comprise a redox-responsive endogenous antioxidant defense module that orchestrates the expression of ...
Gerasimos P. Sykiotis
doaj   +1 more source

Targeting Nrf2/HO-1 anti-oxidant signaling pathway in the progression of multiple sclerosis and influences on neurological dysfunctions

Brain Disorders, 2021
The nuclear factor erythroid 2-related factor (Nrf2) transcription factor/Hemoxygenase 1 (HO-1) is a primary regulator of essential cytoprotective responses in the brain.
Shubham Upadhayay, Sidharth Mehan, Ph.D, M.Pharm   +1 more
doaj   +1 more source

KAT6A regulates stemness of aging bone marrow-derived mesenchymal stem cells through Nrf2/ARE signaling pathway

Stem Cell Research & Therapy, 2021
Background This study aimed to explore the effect of KAT6A on the decreased stemness of aging bone marrow-derived mesenchymal stem cells (BMSCs) and its potential mechanism.
Dongdong Fei, Yazheng Wang, Qiming Zhai, Xige Zhang, Yang Zhang, Yang Wang, Bei Li, Qintao Wang   +7 more
doaj   +1 more source