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Keap1/Nrf2 Signaling Pathway [PDF]

Antioxidants, 2021
Nuclear factor, erythroid 2-like transcription factor 2 (Nrf2) and its cytoplasmic inhibitor, kelch-like ECH-associated protein 1 (Keap1), comprise a redox-responsive endogenous antioxidant defense module that orchestrates the expression of ...
Gerasimos P. Sykiotis
doaj   +4 more sources

Advance in Nrf2 Signaling Pathway in Leishmaniasis. [PDF]

Biomedicines
One of the main components of innate defense against invasive parasites is oxidative stress, which is brought on by reactive oxygen species (ROS). On the other hand, oxidative stressors serve two purposes: free radicals aid in the elimination of pathogens, but they can also set off inflammation, which leads to tissue damage.
Saha S, Sachivkina N, Kuznetsova O, Neborak E, Zhabo N.   +4 more
europepmc   +4 more sources

Isoliquiritigenin as a modulator of the Nrf2 signaling pathway: potential therapeutic implications [PDF]

Frontiers in Pharmacology
Nuclear factor erythroid-2-related factor 2 (Nrf2), a transcription factor responsible for cytoprotection, plays a crucial role in regulating the expression of numerous antioxidant genes, thereby reducing reactive oxygen species (ROS) levels and ...
Mangmang Qiu, Kang Ma, Junfeng Zhang, Zhaohua Zhao, Shan Wang, Qing Wang, Hao Xu   +6 more
doaj   +2 more sources

The role of Nrf2 signaling pathway in diabetic cardiomyopathy: from pathogenesis to traditional Chinese medicine interventions [PDF]

Frontiers in Cardiovascular Medicine
Diabetic cardiomyopathy (DCM), a common diabetic complication independent of hypertension, coronary heart disease and heart valve disease is a major cause of cardiovascular mortality. The pathogenesis of DCM is complex. The Nrf2-related signaling pathway
Huixian Gu, Junchang Liu, Jie Jiang, Hongyan Ma, Siyu Wu, Longfei Sun, Longfei Sun, Lan Yao, Lan Yao   +8 more
doaj   +2 more sources

Mechanism of Neutrophil p90RSK-Nrf2 Signaling Pathway in Atherosclerosis. [PDF]

Balkan Med J
BACKGROUND: MRP8/14, a calcium-binding protein of the S100 family, is predominantly expressed in myeloid cells and exhibits proinflammatory and prothrombotic properties. Platelet-neutrophil interactions can trigger MRP8/14 release, but their role in atherosclerosis (AS) remains unclear.
Li J, Wang L, Liang X, Li X.
europepmc   +3 more sources

Interaction of saffron and its constituents with Nrf2 signaling pathway: A review [PDF]

Iranian Journal of Basic Medical Sciences, 2022
Saffron (Crocus sativus) is a natural compound and its constituents such as crocin, crocetin, and safranal have many pharmacological properties such as anti-oxidant, anti-inflammatory, antitumor, antigenotoxic, anti-depressant, hepatoprotective ...
Arian Khoshandam, Bibi Marjan Razavi, Hossein Hosseinzadeh   +2 more
doaj   +1 more source

Therapeutic Targeting of the NRF2 Signaling Pathway in Cancer [PDF]

Molecules, 2021
Cancer is one of the most fatal diseases with an increasing incidence and mortality all over the world. Thus, there is an urgent need for novel therapies targeting major cancer-related pathways. Nuclear factor-erythroid 2-related factor 2 (NRF2) and its major negative modulator Kelch-like ECH-associated protein 1 (KEAP1) are main players of the ...
Pelin Telkoparan-Akillilar, Emiliano Panieri, Dilek Cevik, Sibel Suzen, Luciano Saso   +4 more
openaire   +4 more sources

NRF2 regulates HER1 signaling pathway to modulate the sensitivity of ovarian cancer cells to lapatinib and erlotinib [PDF]

, 2017
NF-E2-related factor 2 (NRF2) regulates the transcription of a battery of metabolic and cytoprotective genes. NRF2 and epidermal growth factor receptors (EGFRs/HERs) are regulators of cellular proliferation and determinants of cancer initiation and ...
Bown, James L., Deeni, Yusuf Y., Hamza Kankia, Ibrahim, Khalil, Hilal S., Langdon, Simon P., Moult, Peter R.   +5 more
core   +14 more sources

Activation of Nrf2 in Astrocytes Suppressed PD-Like Phenotypes via Antioxidant and Autophagy Pathways in Rat and Drosophila Models

Cells, 2021
The oxidative-stress-induced impairment of autophagy plays a critical role in the pathogenesis of Parkinson’s disease (PD). In this study, we investigated whether the alteration of Nrf2 in astrocytes protected against 6-OHDA (6-hydroxydopamine)- and ...
Qing Guo, Bing Wang, Xiaobo Wang, Wanli W. Smith, Yi Zhu, Zhaohui Liu   +5 more
doaj   +1 more source

Recent Advances in the Role of Nuclear Factor Erythroid-2-Related Factor 2 in Spinal Cord Injury: Regulatory Mechanisms and Therapeutic Options

Frontiers in Aging Neuroscience, 2022
Nuclear factor erythroid-2-related factor 2 (Nrf2) is a pleiotropic transcription factor, and it has been documented that it can induce defense mechanisms both oxidative stress and inflammatory injury.
Tianqi Jiang, Tianqi Jiang, Yongxiong He
doaj   +1 more source