Results 21 to 30 of about 78,211 (259)
Antioxidants, 2023 Hyperuricemia (HUA)-induced oxidative stress is a crucial contributor to hyperuricemic nephropathy (HN), but the molecular mechanisms underlying the disturbed redox homeostasis in kidneys remain elusive.
Panshuang Qiao +9 more
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An Overview of Nrf2 Signaling Pathway and Its Role in Inflammation [PDF]
Molecules, 2020 Inflammation is a key driver in many pathological conditions such as allergy, cancer, Alzheimer’s disease, and many others, and the current state of available drugs prompted researchers to explore new therapeutic targets. In this context, accumulating evidence indicates that the transcription factor Nrf2 plays a pivotal role controlling the expression ...
Sarmistha Saha +4 more
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The Role of NRF2/KEAP1 Signaling Pathway in Cancer Metabolism [PDF]
International Journal of Molecular Sciences, 2021 The nuclear factor-erythroid 2 p45-related factor 2 (NRF2, also called Nfe2l2) and its cytoplasmic repressor, Kelch-like ECH-associated protein 1 (KEAP1), are major regulators of redox homeostasis controlling a multiple of genes for detoxification and cytoprotective enzymes.
Moon-Young Song +3 more
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Scientific Reports, 2022 Ferroptosis is a newly discovered mode of cell death that involves disorders in iron metabolism and the accumulation of reactive oxygen species (ROS) in the plasma membrane.
Tingting Liao +3 more
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Molecular and Chemical Regulation of the Keap1-Nrf2 Signaling Pathway [PDF]
Molecules, 2014 Extracellular and intracellular oxidants or electrophiles are key contributors to the damages in cellular macromolecules, such as DNA, proteins and lipids. Nrf2 is a master transcription factor that modulates a cellular antioxidant response program and plays an important role in the protection against oxidants and electrophiles.
Young-Sam Keum, Bu Young Choi
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The Keap1/Nrf2 Signaling Pathway in the Thyroid—2020 Update [PDF]
Antioxidants, 2020 The thyroid gland has a special relationship with oxidative stress. On the one hand, like all other tissues, it must defend itself against reactive oxygen species (ROS). On the other hand, unlike most other tissues, it must also produce reactive oxygen species in order to synthesize its hormones that contribute to the homeostasis of other tissues.
Christina Thanas +4 more
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Regulatory Role of Nrf2 Signaling Pathway in Wound Healing Process [PDF]
Molecules, 2021 Wound healing involves a series of cellular events in damaged cells and tissues initiated with hemostasis and finally culminating with the formation of a fibrin clot. However, delay in the normal wound healing process during pathological conditions due to reactive oxygen species, inflammation and immune suppression at the wound site represents a ...
Ipek Süntar +6 more
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Targeting Nrf2 signaling in dry eye [PDF]
International Journal of OphthalmologyDry eye, the most common ocular surface disease, can cause ocular surface tissue damage and discomfort symptoms and seriously affect people's quality of life. The etiology of dry eye is diverse, and its pathogenesis is complex.
Yu-Nuo Zhang +3 more
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Journal of International Medical Research, 2019 Objective To evaluate the effect of GSTA3 within the PI3K–Keap1/Nrf2 pathway in renal interstitial fibrosis (RIF). Methods An in vitro RIF model with TGF-β1 stimulation in NRK-52E cells was established to identify potential signaling pathways that ...
Yun Xiao +5 more
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Natural Products as Modulators of Nrf2 Signaling Pathway in Neuroprotection
International Journal of Molecular Sciences, 2023 Neurodegenerative diseases (NDs) affect the West due to the increase in life expectancy. Nervous cells accumulate oxidative damage, which is one of the factors that triggers and accelerates neurodegeneration. However, cells have mechanisms that scavenge reactive oxygen species (ROS) and alleviate oxidative stress (OS).
Ignacio Moratilla-Rivera +3 more
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