Results 31 to 40 of about 78,211 (259)

The therapeutic effect of resveratrol: Focusing on the Nrf2 signaling pathway

Biomedicine & Pharmacotherapy, 2020
Resveratrol is a natural polyphenol derived from grapes, berries, red wine, peanuts amongst other fruits and nuts. Beneficial effects such as anti-inflammatory, antioxidant, hepatoprotective, neuroprotective, cardioprotective, renoprotective, anti-obesity, anti-diabetic, and anti-cancer of resveratrol have been demonstrated by preclinical and clinical ...
Farkhondeh, Tahereh, Llorens Folgado, Silvia, Pourbagher-Shahri, Ali Mohammad, Ashrafizadeh, Milad, Samarghandian, Saeed   +4 more
openaire   +3 more sources

The emerging role of the Nrf2–Keap1 signaling pathway in cancer [PDF]

Genes & Development, 2013
The Nrf2 (nuclear factor erythroid 2 [NF-E2]-related factor 2 [Nrf2])–Keap1 (Kelch-like erythroid cell-derived protein with CNC homology [ECH]-associated protein 1) signaling pathway is one of the most important cell defense and survival pathways.
Jaramillo, Melba C., Zhang, Donna D.
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Signal amplification in the KEAP1-NRF2-ARE antioxidant response pathway

Redox Biology, 2022
The KEAP1-NRF2-ARE signaling pathway plays a central role in mediating the adaptive cellular stress response to oxidative and electrophilic chemicals. This canonical pathway has been extensively studied and reviewed in the past two decades, but rarely was it looked at from a quantitative signaling perspective.
Shengnan Liu, Jingbo Pi, Qiang Zhang
openaire   +3 more sources

Nrf2 signaling pathway: Pivotal roles in inflammation

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2017
Inflammation is the most common feature of many chronic diseases and complications, while playing critical roles in carcinogenesis. Several studies have demonstrated that Nrf2 contributes to the anti-inflammatory process by orchestrating the recruitment of inflammatory cells and regulating gene expression through the antioxidant response element (ARE).
Syed Minhaj Uddin, Ahmed, Lin, Luo, Akhileshwar, Namani, Xiu Jun, Wang, Xiuwen, Tang   +4 more
openaire   +2 more sources

The anti-tumor effect of proteasome inhibitor MG132 for human adenoid cystic carcinoma: correlate with the emerging role of Nrf2/Keap1 signaling pathway

Head & Face Medicine, 2022
Background Adenoid cystic carcinoma (ACC) is one of the most common malignant salivary gland tumors. Moreover, the unique biological characteristics and complex structures of ACC contribute to its poor survival rates. Recently, proteasome inhibitors have
Jiazhi Xu, Haiwei Wu, Jiatong Sun, Zhiyuan Gong, Xiaoya Lu, Enli Yang, Zhanwei Chen, Shengyun Huang, Xiaolin Nong, Dongsheng Zhang   +9 more
doaj   +1 more source

Grub polypeptide extracts protect against oxidative stress through the NRF2-ARE signaling pathway

Animal Cells and Systems, 2021
Grub polypeptide extracts (GPEs) have antioxidant effects; however, their underlying molecular mechanisms are unknown. This study explored the antioxidant molecular mechanism of GPE via the nuclear factor-erythroid 2-related factor 2 (NRF2)-antioxidant ...
Jingyang Chen, Yingjian Sun, Shan Huang, Hong Shen, Yongjie Chen   +4 more
doaj   +1 more source

Keap1-Nrf2 pathway: a key mechanism in the occurrence and development of cancer

Frontiers in Oncology
The Keap1-Nrf2 signaling pathway is a major regulator of the cytoprotective response, participating in endogenous and exogenous stress caused by ROS (reactive oxygen species). Nrf2 is the core of this pathway.
Feilong Chen, Mei Xiao, Shaofan Hu, Meng Wang   +3 more
doaj   +1 more source

Regulation of redox processes in biological systems with the participation of the Keap1/Nrf2/ARE signaling pathway, biogenic selenium nanoparticles as Nrf2 activators

Regulatory Mechanisms in Biosystems, 2020
The article is devoted to the mechanisms of regulation of redox processes in cells, a review of the Keap1 / Nrf2 / ARE redox-sensitive signaling system as a fundamental pathway that plays a key role in maintaining cellular redox homeostasis under ...
V. S. Bityutsky, S. I. Tsekhmistrenko, О. S. Tsekhmistrenko, N. O. Tymoshok, M. Y. Spivak   +4 more
doaj   +1 more source

The Antioxidative Action of ZTP by Increasing Nrf2/ARE Signal Pathway

Evidence-Based Complementary and Alternative Medicine, 2019
So far, more than 25,000 brain diseases have been shown to be related to oxidative stress. Excessive free radicals and reactive oxygen species (ROS) can attack cells resulting in dysfunctional proteins, lipids, and nucleic acid, finally leading to imbalance of energy metabolism, cell death, gene mutation, and immune reaction. Therefore oxidative stress
Liang Yang, Bing Xu, Chunxu Yuan, Zhi Dai, Yong Wang, Qiongya Li, Qifan Yang, Nuomin Li, Hong Qing   +8 more
openaire   +2 more sources

Involvement of the p62/NRF2 signal transduction pathway on erythrophagocytosis [PDF]

Scientific Reports, 2017
AbstractErythrophagocytosis, the phagocytic removal of damaged red blood cells (RBC), and subsequent phagolysosome biogenesis are important processes in iron/heme metabolism and homeostasis. Phagolysosome biogenesis implies the interaction of nascent phagosomes with endocytic compartments and also autophagy effectors.
Inês B. Santarino, Michelle S. Viegas, Neuza S. Domingues, Ana M. Ribeiro, Miguel P. Soares, Otília V. Vieira   +5 more
openaire   +4 more sources