Results 31 to 40 of about 112,785 (303)

Nrf2 signaling pathway: Pivotal roles in inflammation

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2017
Inflammation is the most common feature of many chronic diseases and complications, while playing critical roles in carcinogenesis. Several studies have demonstrated that Nrf2 contributes to the anti-inflammatory process by orchestrating the recruitment of inflammatory cells and regulating gene expression through the antioxidant response element (ARE).
Syed Minhaj Uddin, Ahmed, Lin, Luo, Akhileshwar, Namani, Xiu Jun, Wang, Xiuwen, Tang   +4 more
openaire   +2 more sources

Targeting Nrf2 signaling in dry eye [PDF]

International Journal of Ophthalmology
Dry eye, the most common ocular surface disease, can cause ocular surface tissue damage and discomfort symptoms and seriously affect people's quality of life. The etiology of dry eye is diverse, and its pathogenesis is complex.
Yu-Nuo Zhang, Wei-Jie Ouyang, Jiao-Yue Hu, Zu-Guo Liu   +3 more
doaj   +1 more source

A novel mechanism of action of HER2 targeted immunotherapy is explained by inhibition of NRF2 function in ovarian cancer cells [PDF]

, 2016
Nuclear erythroid related factor-2 (NRF2) is known to promote cancer therapeutic detoxification and crosstalk with growth promoting pathways. HER2 receptor tyrosine kinase is frequently overexpressed in cancers leading to uncontrolled receptor activation
Bown, James, Deeni, Yusuf Y., Goltsov, Alexey, Harrison, David J., Khalil, Hilal S., Langdon, Simon P., Soininen, Tero   +6 more
core   +3 more sources

Biomarker Exploration in Human Peripheral Blood Mononuclear Cells for Monitoring Sulforaphane Treatment Responses in Autism Spectrum Disorder [PDF]

, 2020
Autism Spectrum Disorder (ASD) is one of the most common neurodevelopmental disorders with no drugs treating the core symptoms and no validated biomarkers for clinical use.
Connors, Susan L., Diggins, Eileen, Dinkova-Kostova, Albena, Fahey, Jed W., Liu, Hua, Singh, Kanwaljit, Stephenson, Katherine K., Zimmerman, Andrew W.   +7 more
core   +3 more sources

KEAP1/NRF2 signaling pathway mutations in cervical cancer.

European review for medical and pharmacological sciences, 2018
The aim of the present study was to explore the potential involvement of mutations in the KEAP1/NRF2 signaling pathway in Chinese samples with cervical cancer.236 Chinese patients with various types of cervical cancer were recruited, and the coding exons and the corresponding intron-exon boundaries of the KEAP1 and NRF2 genes were analyzed for the ...
Chu, X.-Y., Li, Z.-J., Zheng, Z.-W., Tao, Y.-L., Zou, F.-X., Yang, X.-F.   +5 more
openaire   +2 more sources

GSTA3 regulates TGF-1-induced renal interstitial fibrosis in NRK-52E cells as a component of the PI3K–Keap1/Nrf2 pathway

Journal of International Medical Research, 2019
Objective To evaluate the effect of GSTA3 within the PI3K–Keap1/Nrf2 pathway in renal interstitial fibrosis (RIF). Methods An in vitro RIF model with TGF-β1 stimulation in NRK-52E cells was established to identify potential signaling pathways that ...
Yun Xiao, Zhiwei Zhang, Yingyu Fu, Huizhi Shan, Sini Cui, Jun Wu   +5 more
doaj   +1 more source

Argon protects against hypoxic-ischemic brain injury in neonatal rats through activation of Nuclear factor (erythroid-derived 2)-like 2 [PDF]

, 2016
Perinatal hypoxic ischaemic encephalopathy (HIE) has a high mortality rate with neuropsychological impairment. This study investigated the neuroprotective effects of argon against neonatal hypoxic-ischaemic brain injury.
Ciechanowicz, S, Ji, X, Ma, D, Mitchell, S, Savage, S, Wang, T, Zhao, H   +6 more
core   +1 more source

Morin Induces Heme Oxygenase-1 via ERK-Nrf2 Signaling Pathway [PDF]

Journal of Cancer Prevention, 2013
Oxidative stress damages to cells or tissues, however, cellular defense systems including heme oxygenase-1 (HO-1) protects them against oxidative stress. Flavonoid compounds can activate cellular defense mechanisms against oxidative stress and it can reduce cell damages.
Park, Ji Young, Kang, Kyoung Ah, Kim, Ki Cheon, Cha, Ji Won, Kim, Eun Hee, Hyun, Jin Won   +5 more
openaire   +2 more sources

The Keap1/Nrf2 Signaling Pathway in the Thyroid—2020 Update [PDF]

Antioxidants, 2020
The thyroid gland has a special relationship with oxidative stress. On the one hand, like all other tissues, it must defend itself against reactive oxygen species (ROS). On the other hand, unlike most other tissues, it must also produce reactive oxygen species in order to synthesize its hormones that contribute to the homeostasis of other tissues.
Christina Thanas, Panos G. Ziros, Dionysios V. Chartoumpekis, Cédric O. Renaud, Gerasimos P. Sykiotis   +4 more
openaire   +4 more sources

HDAC inhibitors increase NRF2-signaling in tumour cells and blunt the efficacy of co-adminstered cytotoxic agents [PDF]

, 2014
The NRF2 signalling cascade provides a primary response against electrophilic chemicals and oxidative stress. The activation of NRF2-signaling is anticipated to have adverse clinical consequences; NRF2 is activated in a number of cancers and ...
Campbell, Kathryn H., Henderson, Colin J., MacLeod, A. Kenneth, McLaughlin, Lesley A., McMahon, Michael, Wolf, C. Roland   +5 more
core   +7 more sources