Results 11 to 20 of about 78,211 (259)

Therapeutic Targeting of the NRF2 Signaling Pathway in Cancer [PDF]

Molecules, 2021
Cancer is one of the most fatal diseases with an increasing incidence and mortality all over the world. Thus, there is an urgent need for novel therapies targeting major cancer-related pathways. Nuclear factor-erythroid 2-related factor 2 (NRF2) and its major negative modulator Kelch-like ECH-associated protein 1 (KEAP1) are main players of the ...
Pelin Telkoparan-Akillilar, Emiliano Panieri, Dilek Cevik, Sibel Suzen, Luciano Saso   +4 more
openaire   +4 more sources

Mechanism of Neutrophil p90RSK-Nrf2 Signaling Pathway in Atherosclerosis. [PDF]

Balkan Med J
MRP8/14, a calcium-binding protein of the S100 family, is predominantly expressed in myeloid cells and exhibits proinflammatory and prothrombotic properties. Platelet-neutrophil interactions can trigger MRP8/14 release, but their role in atherosclerosis (AS) remains unclear.To investigate the effect of MRP8/14 on AS progression and the underlying ...
Li J, Wang L, Liang X, Li X.
europepmc   +4 more sources

Molecular Basis of the KEAP1-NRF2 Signaling Pathway

Molecules and Cells, 2023
Transcription factor NRF2 (NF-E2-related factor 2) is a master regulator of cellular responses against environmental stresses. NRF2 induces expression of detoxification and antioxidant enzymes and suppresses inductions of pro-inflammatory cytokine genes.
Takafumi Suzuki, Jun Takahashi, Masayuki Yamamoto   +2 more
openaire   +2 more sources

Advance in Nrf2 Signaling Pathway in Leishmaniasis. [PDF]

Biomedicines
One of the main components of innate defense against invasive parasites is oxidative stress, which is brought on by reactive oxygen species (ROS). On the other hand, oxidative stressors serve two purposes: free radicals aid in the elimination of pathogens, but they can also set off inflammation, which leads to tissue damage.
Saha S, Sachivkina N, Kuznetsova O, Neborak E, Zhabo N.   +4 more
europepmc   +4 more sources

Coumarins as Modulators of the Keap1/Nrf2/ARE Signaling Pathway

Oxidative Medicine and Cellular Longevity, 2020
The Keap1/Nrf2/ARE system is a central defensive mechanism against oxidative stress which plays a key role in the pathogenesis and progression of many diseases. Nrf2 is a redox-sensitive transcription factor controlling a variety of downstream antioxidant and cytodefensive genes. Nrf2 has a powerful anti-inflammatory activity mediated via modulating NF-
Emad H. M. Hassanein, Ahmed M. Sayed, Omnia E. Hussein, Ayman M. Mahmoud   +3 more
openaire   +3 more sources

Anti-Osteoarthritis Mechanism of the Nrf2 Signaling Pathway

Biomedicines, 2023
Osteoarthritis (OA) is a chronic degenerative disease and the primary pathogenic consequence of OA is inflammation, which can affect a variety of tissues including the synovial membrane, articular cartilage, and subchondral bone. The development of the intra-articular microenvironment can be significantly influenced by the shift of synovial macrophages
Sarmistha Saha, Nazih Y. Rebouh
openaire   +4 more sources

The KEAP1/NRF2 Signaling Pathway in Keratinization

Antioxidants, 2020
Keratinization is a tissue adaptation, but aberrant keratinization is associated with skin disorders such as ichthyoses, atopic dermatitis, psoriasis, and acne. The disease phenotype stems from the interaction between genes and the environment; therefore, an understanding of the adaptation machinery may lead to a new appreciation of pathomechanisms ...
Yosuke Ishitsuka, Tatsuya Ogawa, Dennis Roop   +2 more
openaire   +3 more sources

ROS-Nrf2 pathway mediates the development of TGF-β1-induced epithelial-mesenchymal transition through the activation of Notch signaling

European Journal of Cell Biology, 2021
Epithelial-mesenchymal transition (EMT) is a cellular process by which epithelial cells transform to acquire mesenchymal phenotypes. Accumulating evidence indicate the involvement of EMT in the progression of malignant diseases.
Kai Yazaki, Yosuke Matsuno, Kazufumi Yoshida, Mingma Sherpa, Masayuki Nakajima, Masashi Matsuyama, Takumi Kiwamoto, Yuko Morishima, Yukio Ishii, Nobuyuki Hizawa   +9 more
doaj   +1 more source

Z-REX uncovers a bifurcation in function of Keap1 paralogs

eLife, 2022
Studying electrophile signaling is marred by difficulties in parsing changes in pathway flux attributable to on-target, vis-à-vis off-target, modifications.
Alexandra Van Hall-Beauvais, Jesse R Poganik, Kuan-Ting Huang, Saba Parvez, Yi Zhao, Hong-Yu Lin, Xuyu Liu, Marcus John Curtis Long, Yimon Aye   +8 more
doaj   +1 more source

SMURF1 attenuates endoplasmic reticulum stress by promoting the degradation of KEAP1 to activate NRF2 antioxidant pathway

Cell Death and Disease, 2023
Cancer cells consistently utilize the unfolded protein response (UPR) to encounter the abnormal endoplasmic reticulum (ER) stress induced by the accumulation of misfolded proteins.
Lei Dong, Mengchuan Xu, Yang Li, Wanting Xu, Chengwei Wu, Hanfei Zheng, Zhenyu Xiao, Guochen Sun, Lei Ding, Xiaobo Li, Wenming Li, Liying Zhou, Qin Xia   +12 more
doaj   +1 more source