Results 11 to 20 of about 112,785 (303)
The Role of NRF2/KEAP1 Signaling Pathway in Cancer Metabolism [PDF]
International Journal of Molecular Sciences, 2021 The nuclear factor-erythroid 2 p45-related factor 2 (NRF2, also called Nfe2l2) and its cytoplasmic repressor, Kelch-like ECH-associated protein 1 (KEAP1), are major regulators of redox homeostasis controlling a multiple of genes for detoxification and cytoprotective enzymes.
Moon-Young Song +3 more
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Signal amplification in the KEAP1-NRF2-ARE antioxidant response pathway
Redox Biology, 2022 The KEAP1-NRF2-ARE signaling pathway plays a central role in mediating the adaptive cellular stress response to oxidative and electrophilic chemicals. This canonical pathway has been extensively studied and reviewed in the past two decades, but rarely was it looked at from a quantitative signaling perspective.
Shengnan Liu, Jingbo Pi, Qiang Zhang
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Targeting Nrf2/KEAP1 signaling pathway using bioactive compounds to combat mastitis
Frontiers in ImmunologyMastitis is a common inflammation of mammary glands that has a significantly impact on dairy production and animal health, causing considerable economic burdens worldwide.
Muhammad Zahoor Khan +12 more
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Regulatory Role of Nrf2 Signaling Pathway in Wound Healing Process [PDF]
Molecules, 2021 Wound healing involves a series of cellular events in damaged cells and tissues initiated with hemostasis and finally culminating with the formation of a fibrin clot. However, delay in the normal wound healing process during pathological conditions due to reactive oxygen species, inflammation and immune suppression at the wound site represents a ...
Ipek Süntar +6 more
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Molecular Basis of the KEAP1-NRF2 Signaling Pathway
Molecules and Cells, 2023 Transcription factor NRF2 (NF-E2-related factor 2) is a master regulator of cellular responses against environmental stresses. NRF2 induces expression of detoxification and antioxidant enzymes and suppresses inductions of pro-inflammatory cytokine genes.
Takafumi Suzuki +2 more
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H2O2/DEM-Promoted Maft Promoter Demethylation Drives Nrf2/ARE Activation in Zebrafish
Life, 2022 The Nrf2/ARE signaling pathway is a cell survival response pathway in response to environmental stresses. The Nrf2/ARE signaling pathway can be activated by stimulating cysteine residues at different positions in the Keap1.
Ce Chen +8 more
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Anti-Osteoarthritis Mechanism of the Nrf2 Signaling Pathway
Biomedicines, 2023 Osteoarthritis (OA) is a chronic degenerative disease and the primary pathogenic consequence of OA is inflammation, which can affect a variety of tissues including the synovial membrane, articular cartilage, and subchondral bone. The development of the intra-articular microenvironment can be significantly influenced by the shift of synovial macrophages
Sarmistha Saha, Nazih Y. Rebouh
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Brain Disorders, 2021 The nuclear factor erythroid 2-related factor (Nrf2) transcription factor/Hemoxygenase 1 (HO-1) is a primary regulator of essential cytoprotective responses in the brain.
Shubham Upadhayay +1 more
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Stem Cell Research & Therapy, 2021 Background This study aimed to explore the effect of KAT6A on the decreased stemness of aging bone marrow-derived mesenchymal stem cells (BMSCs) and its potential mechanism.
Dongdong Fei +7 more
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The KEAP1/NRF2 Signaling Pathway in Keratinization
Antioxidants, 2020 Keratinization is a tissue adaptation, but aberrant keratinization is associated with skin disorders such as ichthyoses, atopic dermatitis, psoriasis, and acne. The disease phenotype stems from the interaction between genes and the environment; therefore, an understanding of the adaptation machinery may lead to a new appreciation of pathomechanisms ...
Yosuke Ishitsuka +2 more
openaire +3 more sources