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Modular modelling of signalling pathways and their crosstalk [PDF]
, 2012 Signalling pathways are well-known abstractions that explain the mechanisms whereby cells respond to signals. Collections of pathways form networks, and interactions between pathways in a network, known as cross-talk, enables further complex signalling ...
Calder, M. +3 more
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The emerging role of MicroRNA-182 in tumorigenesis; a promising therapeutic target
Cancer Cell International, 2023 A wide range of studies have indicated that microRNAs (miRNAs), a type of small single-stranded regulatory RNAs, are dysregulated in a different variety of human cancers.
Pouriya Sameti +5 more
doaj +1 more source
How to target apoptosis signaling pathways for the treatment of pediatric cancers [PDF]
, 2013 Apoptosis represents one of the most important forms of cell death in higher organisms and is typically dysregulated in human cancers, including pediatric tumors.
Simone Fulda +2 more
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Siglec-8 Signals Through a Non-Canonical Pathway to Cause Human Eosinophil Death In Vitro
Frontiers in Immunology, 2021 Sialic acid-binding immunoglobulin-like lectin (Siglec)-8 is a glycan-binding receptor bearing immunoreceptor tyrosine-based inhibitory and switch motifs (ITIM and ITSM, respectively) that is selectively expressed on eosinophils, mast cells, and, to a ...
Daniela J. Carroll +3 more
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Mechanisms Underlying Influence of Bioelectricity in Development
Frontiers in Cell and Developmental Biology, 2022 To execute the intricate process of development, cells coordinate across tissues and organs to determine where each cell divides and differentiates. This coordination requires complex communication between cells.
Laura Faith George, Emily Anne Bates
doaj +1 more source
, 2013 Pathways Newsletter 2 provides a brief summary of causal inference, together with information about Pathways courses and events for 2012 ...
Miller, Sarah
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Ожирение и метаболизм5-Pentadecylresorcinol (C15) is a natural alkylresorcinol that has been shown to protect against complications caused by imbalanced nutrition. Although the exact mechanisms of beneficial activity of C15 are not known, we assume that the protective ...
A. A. Zabolotneva +4 more
doaj +1 more source
Interactions of melatonin with various signaling pathways: implications for cancer therapy
Cancer Cell International, 2022 Melatonin is a neuro-hormone with conserved roles in evolution. Initially synthetized as an antioxidant molecule, it has gained prominence as a key molecule in the regulation of the circadian rhythm.
Ainaz Mihanfar +3 more
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A Systems Approach for Decoding Mitochondrial Retrograde Signaling Pathways
, 2018 Mitochondrial dysfunctions activate retrograde signaling from mitochondria to the nucleus. To identify transcription factors and their associated pathways that underlie mitochondrial retrograde signaling, we performed gene expression profiling of the ...
Sehyun Chae +7 more
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BiomedicinesCurrently, obesity is a critical global public health burden. Numerous studies have demonstrated the regulation of the pathogenesis of obesity and metabolic abnormalities by the gut microbiota and microbial factors; however, their involvement in the ...
Anastasia A. Zabolotneva +5 more
doaj +1 more source