Results 41 to 50 of about 2,188,608 (303)

The Obesogenic Gut Microbiota as a Crucial Factor Defining the Depletion of Predicted Enzyme Abundance for Vitamin B12 Synthesis in the Mouse Intestine

Biomedicines
Currently, obesity is a critical global public health burden. Numerous studies have demonstrated the regulation of the pathogenesis of obesity and metabolic abnormalities by the gut microbiota and microbial factors; however, their involvement in the ...
Anastasia A. Zabolotneva, Irina M. Kolesnikova, Ilya Yu. Vasiliev, Tatiana V. Grigoryeva, Sergei A. Roumiantsev, Aleksandr V. Shestopalov   +5 more
doaj   +1 more source

Signalling mechanisms of long term facilitation of breathing with intermittent hypoxia. [PDF]

, 2013
Intermittent hypoxia causes long-term facilitation (LTF) of respiratory motor nerve activity and ventilation, which manifests as a persistent increase over the normoxic baseline for an hour or more after the acute hypoxic ventilatory response.
Pamenter, Matthew E, Powell, Frank L
core   +1 more source

Toll-like receptor signaling pathways

Frontiers in Immunology, 2014
Toll-like receptors (TLRs) play crucial roles in the innate immune system by recognizing pathogen-associated molecular patterns derived from various microbes. TLRs signal through the recruitment of specific adaptor molecules, leading to activation of the
Taro eKawai, Takumi eKawasaki
doaj   +1 more source

Exercise-induced signaling pathways to counteracting cardiac apoptotic processes

Frontiers in Cell and Developmental Biology, 2022
Cardiovascular diseases are the most common cause of death in the world. One of the major causes of cardiac death is excessive apoptosis. However, multiple pathways through moderate exercise can reduce myocardial apoptosis.
Hamed Alizadeh Pahlavani
doaj   +1 more source

A human MAP kinase interactome. [PDF]

, 2010
Mitogen-activated protein kinase (MAPK) pathways form the backbone of signal transduction in the mammalian cell. Here we applied a systematic experimental and computational approach to map 2,269 interactions between human MAPK-related proteins and other ...
A Friedman, A Karydis, A Lunardi, AA Reszka, AC Gavin, AJ Whitmarsh, BP Kelley, C Widmann, Chih-yuan Chiang, Christopher H Martin, Cornelia Kurschner, D Wang, Diane L Barber, DJ LaCount, GD Bader, GL Johnson, J Kim, J Ptacek, JV Olsen, Jyoti Srivastava, K Hayashi, K Venkatesan, KC Gunsalus, L Chang, L Collin, M Baumgartner, M Karin, M Qi, M Rothe, Merril Gersten, Mike Smoot, P Uetz, PJ Cullen, R Hooley, R Konig, R Konig, R Konig, Russell Bell, S Peri, SA Johnson, SK Chanda, Sourav Bandyopadhyay, SP Denker, Sudhir Sahasrabudhe, Suhaila White, Sumit K Chanda, T Ito, T Reguly, Trey Ideker, W Kolch, W Kolch, Y Ho   +51 more
core   +3 more sources

Downregulation of Interleukin-13 Receptor α2 Inhibits Angiogenic Formation Mediated by Chitinase 3-Like 1 in Late Atherosclerotic Lesions of apoE−/− Mice

Frontiers in Physiology, 2021
Aim: Chitinase 3-like 1 (CHI3L1) has the potential to prompt proliferation and angiogenic formation. Interleukin-13 receptor α2 (IL-13Rα2) was regarded as a receptor of CHI3L1; however, it is unknown whether CHI3L1 adjusts the neovascularization in late ...
Qi Xue, Lei Chen, Jianwu Yu, Kewang Sun, Lifang Ye, Jianlei Zheng, Jianlei Zheng   +6 more
doaj   +1 more source

Impaired neurodevelopmental pathways in autism spectrum disorder: a review of signaling mechanisms and crosstalk. [PDF]

, 2019
BackgroundThe development of an autistic brain is a highly complex process as evident from the involvement of various genetic and non-genetic factors in the etiology of the autism spectrum disorder (ASD). Despite being a multifactorial neurodevelopmental
Gu, Ran, Ji, Yu, Kumar, Santosh, Rai, Sunil, Reynolds, Kurt, Zhou, Chengji J   +5 more
core  

High-resolution temporal profiling of transcripts during Arabidopsis leaf senescence reveals a distinct chronology of processes and regulation [PDF]

, 2011
Leaf senescence is an essential developmental process that impacts dramatically on crop yields and involves altered regulation of thousands of genes and many metabolic and signaling pathways, resulting in major changes in the leaf.
Beynon, Jim, Breeze, Emily, Buchanan-Wollaston, Vicky, Denby, Katherine J., Harrison, Elizabeth, Hickman, Richard J., Hill, Claire, Hughes, Linda Karen, Jackson, Stephen D., Jenkins, Dafyd J., Jenner, Carol E., Kiddle, Steven J., Kim, Youn-sung, Legaie, Roxane, McHattie, Stuart, Mead, A., Moore, Jonathan D., Morris, Karl, Ott, Sascha, Penfold, Christopher A., Rand, D. A., Tabrett, Alex, Thomas, Brian, Wild, David L., Zhang, Cunjin   +24 more
core   +2 more sources

Personalized Selumetinib Dosing in Pediatric Neurofibromatosis Type 1: Insights From a Pilot Therapeutic Drug Monitoring Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate selumetinib exposure using therapeutic drug monitoring (TDM) in pediatric patients with neurofibromatosis type 1 (NF1) and plexiform neurofibromas (PN), assess interpatient pharmacokinetic variability, and explore the relationship between drug exposure, clinical response, and adverse effects.
Janka Kovács, Zoltán Köllő, Balázs Gellért Karvaly, Mahmoud Obeidat, Rita Nagy, Péter Hegyi, Brigitta Teutsch, Eszter Tuboly, Miklós Garami   +8 more
wiley   +1 more source

Bufalin Induces Apoptosis of Human Osteosarcoma U-2 OS Cells through Endoplasmic Reticulum Stress, Caspase- and Mitochondria-Dependent Signaling Pathways

Molecules, 2017
Bone cancer is one of the cancer-related diseases, and there are increased numbers of patients with bone cancer worldwide. Therefore the efficacy of treatment of bone cancer is considered extremely vital.
Ching-Hsiao Lee, Yung-Luen Shih, Mei-Hui Lee, Man-Kuan Au, Yung-Liang Chen, Hsu-Feng Lu, Jing-Gung Chung   +6 more
doaj   +1 more source