Results 51 to 60 of about 3,298,558 (257)

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Trends in Cell Signaling Pathways in Neuronal Fate Decision [PDF]

, 2013
During the last decades, numerous studies about stem cells and regenerative medicine highlighted new therapeutic approaches to treat several neurological disorders.

core  

The involvement of signaling pathways in the pathogenesis of osteoarthritis: An update

Journal of Orthopaedic Translation
Osteoarthritis (OA) is one of the most common disabling pathologies, characterized by joint pain and reduced function, significantly worsening the quality of life.
Antonietta Fazio, Alberto Di Martino, Matteo Brunello, Francesco Traina, Maria Vittoria Marvi, Antonio Mazzotti, Cesare Faldini, Lucia Manzoli, Camilla Evangelisti, Stefano Ratti   +9 more
doaj   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Interventions in WNT Signaling to Induce Cardiomyocyte Proliferation:Crosstalk with Other Pathways

, 2020
Myocardial infarction is a frequent cardiovascular event and a major cause for cardiomyocyte loss. In adult mammals, cardiomyocytes are traditionally considered to be terminally differentiated cells, unable to proliferate.
Blankesteijn, W. Matthijs
core   +1 more source

Midkine-A functions upstream of Id2a to regulate cell cycle kinetics in the developing vertebrate retina

Neural Development, 2012
Background Midkine is a small heparin binding growth factor expressed in numerous tissues during development. The unique midkine gene in mammals has two paralogs in zebrafish: midkine-a (mdka) and midkine-b (mdkb).
Luo Jing, Uribe Rosa A, Hayton Sarah, Calinescu Anda-Alexandra, Gross Jeffrey M, Hitchcock Peter F   +5 more
doaj   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Systematic identification of signaling pathways with potential to confer anticancer drug resistance [PDF]

, 2014
Cancer cells can activate diverse signaling pathways to evade the cytotoxic action of drugs. We created and screened a library of barcoded pathway-activating mutant complementary DNAs to identify those that enhanced the survival of cancer cells in the ...
Wang, Tim, Sabatini, David, Ottina, Kathleen, Martz, C. A., Tetzlaff, M., Anderson, G. R., Flaherty, K. T., Singleton, K. R., Jasper, J. S., Kwong, L. N., Alley, H. M., Rathmell, J. C., Wood, K. C., Cooper, Z. A., Wardell, S. E., Chen, P.-L., Peraza-Penton, A., McDonnell, D. P., Winter, P. S., Wargo, J. A.   +19 more
core   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells. [PDF]

FEBS Open Bio
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Ibrahim M, Corazzari M, Osman I, Armstrong J, Carter N.   +4 more
europepmc   +2 more sources

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source