Results 61 to 70 of about 3,298,558 (257)

A phenotypic screen in zebrafish identifies a novel small-molecule inducer of ectopic tail formation suggestive of alterations in non-canonical Wnt/PCP signaling [PDF]

, 2013
Zebrafish have recently emerged as an attractive model for the in vivo bioassay-guided isolation and characterization of pharmacologically active small molecules of natural origin.
Alexander D. Crawford, Crawford, Alexander D, Alexander I. Gray, Cordero-Maldonado, María Lorena, de Witte, Peter A M, Gray, Alexander I, Alan L Harvey, Camila V. Esguerra, Gebruers, Evelien, Evelien Gebruers, Harvey, Alan L, Carol Clements, Clements, Carol, Alexander D Crawford, Edrada-Ebel, Ruangelie, Camila V Esguerra, Alan L. Harvey, Ruangelie Edrada-Ebel, Esguerra, Camila V, María Lorena Cordero-Maldonado, Alexander I Gray, Peter A M de Witte, Cordero Maldonado, María Lorena, Peter A. M. de Witte, Edrada-Ebel, R., CRAWFORD, Alexander Dettmar, De Witte, P. A. M., Crawford Alexander D., Clements Carol, de Witte Peter A. M., Cordero-Maldonado, M. L., Gebruers, E., Edrada-Ebel Ruangelie, Esguerra, C. V., Cordero-Maldonado María Lorena, Gray Alexander I., Clements, C., Gebruers Evelien, Harvey, A. L., Esguerra Camila V., Gray, A. I., Harvey Alan L.   +41 more
core   +4 more sources

Towards an enhanced understanding of osteoanabolic effects of PTH-induced microRNAs on osteoblasts using a bioinformatic approach

Frontiers in Endocrinology
In this study, we used a bioinformatic approach to construct a miRNA-target gene interaction network potentially involved in the anabolic effect of parathyroid hormone analogue teriparatide [PTH (1–34)] on osteoblasts.
Lucija Ana Vrščaj, Janja Marc, Janja Marc, Barbara Ostanek   +3 more
doaj   +1 more source

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

O-GlcNAcylation of master growth repressor DELLA by SECRET AGENT modulates multiple signaling pathways in Arabidopsis [PDF]

, 2016
The DELLA family of transcription regulators functions as master growth repressors in plants by inhibiting phytohormone gibberellin (GA) signaling in response to developmental and environmental cues.
Cockrell, S., Shabanowitz, J., Hunt, D. F., Matsumoto, P. A., Hsieh, W. P., Oldenhof, H., Boyce, M., Zentella, R., Thomas, S. G., Barnhill, B., Dawdy, A., Olszewski, N. E., Maitra, S., Hartweck, L. M., Sun, T. P., Hu, J. H.   +15 more
core   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

TGFβ Family Signaling Pathways in Pluripotent and Teratocarcinoma Stem Cells’ Fate Decisions: Balancing Between Self-Renewal, Differentiation, and Cancer

, 2019
The transforming growth factor-β (TGFβ) family factors induce pleiotropic effects and are involved in the regulation of most normal and pathological cellular processes.
Olga Gordeeva
core   +1 more source

PECAM-1 engagement counteracts ICAM-1-induced signaling in brain vascular endothelial cells [PDF]

, 2007
Interactions between leukocytes and vascular endothelial cells are mediated by a complex set of membrane adhesion molecules which transduce bi-directional signals in both cell types.
Laran-Chich, M.-P., Bourdoulous, S., Pierre-Olivier Couraud, John Greenwood, Leveque, M., Greenwood, J., Mathilde Leveque, Rampon, C., Couraud, P.-O., Jean-Pierre Couty, Christine Rampon, Marie-Pierre Laran-Chich, Couty, J.-P., Sandrine Bourdoulous   +13 more
core   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Association of Inorganics Accumulation with the Activation of NF-κB Signaling Pathway and the iNOS Expression of Lung Tissue in Xuanwei Lung Cancer Patients

Chinese Journal of Lung Cancer, 2016
Background and objective Indoor air pollution induces asthma, leads to chronic obstructive pulmonary disease, and may promote lung cancer. Our previous studies found that the accumulation of inorganic particulate matter that is due to indoor air ...
Jiapeng YANG, Guangjian LI, Yunchao HUANG, Lianhua YE, Yongchun ZHOU, Guangqiang ZHAO, Yujie LEI, Xiaobo CHEN, Kun WANG, Ying CHEN, Chun DAI, Yanjun ZHANG   +11 more
doaj   +1 more source