Results 11 to 20 of about 2,188,608 (303)

Signaling Pathways in Pregnancy

Cells, 2022
We are pleased to present this Special Issue of Cells, entitled ‘Signaling Pathways in Pregnancy’ [...]
Giovanni Tossetta, Daniela Marzioni
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p38 Signalling Pathway [PDF]

International Journal of Molecular Sciences, 2021
p38 Mitogen activated protein kinases (p38MAPK) are a highly evolutionary conserved group of protein kinases, which are central for cell adaptation to environmental changes as well as for immune response, inflammation, tissue regeneration, and tumour formation [...]
Juan José Sanz-Ezquerro, Ana Cuenda
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SnapShot: PTEN Signaling Pathways [PDF]

Cell, 2008
is causative for familial diseases including Cowden syndrome, which is characterized by multiple hamartomas, developmental defects, and increased cancer susceptibility.The major tumor-suppressive activity of PTEN is attributed to its ability to hydrolyze the 3′ phosphate of phosphoinositides at the plasma membrane and thereby negatively regulate ...
Carracedo A, Salmena L, PANDOLFI DE RINALDIS, Pier Paolo   +2 more
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Moonlight functions of glycolytic enzymes in cancer

Frontiers in Molecular Biosciences, 2023
Since an extensive genome research has started, basic principle “one gene—one protein—one function” was significantly revised. Many proteins with more than one function were identified and characterized as “moonlighting” proteins, which activity depend ...
Petr V. Shegay, Olga P. Shatova, Olga P. Shatova, Anastasia A. Zabolotneva, Anastasia A. Zabolotneva, Aleksandr V. Shestopalov, Aleksandr V. Shestopalov, Aleksandr V. Shestopalov, Andrei D. Kaprin, Andrei D. Kaprin   +9 more
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Parmodulins Inhibit Thrombus Formation Without Inducing Endothelial Injury Caused by Vorapaxar [PDF]

, 2015
Protease-activated receptor-1 (PAR1) couples the coagulation cascade to platelet activation during myocardial infarction and to endothelial inflammation during sepsis. This receptor demonstrates marked signaling bias.
Ahn, Andrade-Gordon, Andrews, Bae, Bae, Bae, Bernatowicz, Capodanno, Chackalamannil, Chandra C. Ghosh, Chris Dockendorff, Christian G. Peters, Connolly, Covic, Dockendorff, Dowal, Garcia, Griffin, James R. Dilks, Karen De Ceunynck, Kataoka, Katritch, Knezevic, Kosoglou, Kosoglou, Lee, Matsuoka, May, McCoy, Mingdong Huang, Moers, Morrow, Mosnier, Mosnier, Mosnier, Nicholls, Offermanns, Omozuanvbo Aisiku, O’Callaghan, O’Donoghue, Riewald, Riewald, Robert Flaumenhaft, Salchow, Samir M. Parikh, Susanna F. Fustolo-Gunnink, Swift, Taylor, Tressel, Tricoci, Vanhoorelbeke, Wiviott, Zhang   +52 more
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Molecular Mechanisms of Kidney Injury and Repair in Arterial Hypertension [PDF]

, 2019
The global burden of chronic kidney disease is rising. The etiologies, heterogeneous, and arterial hypertension, are key factors contributing to the development and progression of chronic kidney disease. Arterial hypertension is induced and maintained by
Eckardt, Kai-Uwe, Sievers, Laura Katharina   +1 more
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Genetic alterations in melanoma [PDF]

Medicinski Podmladak
Melanoma, an aggressive skin tumor with a high mortality rate in advanced stages, represents a global health challenge. Genetic alterations play a pivotal role in its onset and progression.
Đunjić Marija, Perović Dijana, Šupić Gordana   +2 more
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Targeting RTK signaling pathways in cancer [PDF]

, 2015
The RAS/MAP kinase and the RAS/PI3K/AKT pathways play a key role in the regulation of proliferation, differentiation and survival. The induction of these pathways depends on Receptor Tyrosine Kinases (RTKs) that are activated upon ligand binding.
Regad, T
core   +1 more source

How to rewire the host cell: A home improvement guide for intracellular bacteria. [PDF]

, 2017
Intracellular bacterial pathogens have developed versatile strategies to generate niches inside the eukaryotic cells that allow them to survive and proliferate.
Cornejo, Elias, Mukherjee, Shaeri, Schlaermann, Philipp   +2 more
core   +2 more sources

Ap4 is rate limiting for intestinal tumor formation by controlling the homeostasis of intestinal stem cells

Nature Communications, 2018
The c-MYC oncoprotein has many targets whose actions are not fully understood including TFAP4/AP4. Here, the authors show in a mouse model of inherited colorectal cancer that deletion of AP4 decreased the frequency of c-MYC-driven intestinal adenomas ...
Stephanie Jaeckel, Markus Kaller, Rene Jackstadt, Ursula Götz, Susanna Müller, Sophie Boos, David Horst, Peter Jung, Heiko Hermeking   +8 more
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