Results 201 to 210 of about 342,848 (311)

QTL mapping and identification of genes associated with the resistance to Acanthoscelides obtectus in cultivated common bean using a high-density genetic linkage map. [PDF]

BMC Plant Biol, 2022
Li X, Tang Y, Wang L, Chang Y, Wu J, Wang S.   +5 more
europepmc   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Construction of a genetic linkage map and QTL mapping of the agronomic traits in Foxtail millet (Setaria italica). [PDF]

BMC Genomics
Gao L, Zhu Q, Li H, Wang S, Fan J, Wang T, Yang L, Zhao Y, Ma Y, Chen L, Li X, Dong S, Chu X, Diao X, Yuan X, Wang J, Yang G.   +16 more
europepmc   +1 more source

A High-Density Genetic Linkage Map and Fine Mapping of QTL For Feed Conversion Efficiency in Common Carp (Cyprinus carpio). [PDF]

Front Genet, 2021
Zhang X, Luan P, Cao D, Hu G.
europepmc   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Identification of Submergence Tolerance Loci in Dongxiang Wild Rice (DXWR) by Genetic Linkage and Transcriptome Analyses. [PDF]

Int J Mol Sci
Wang J, Huang C, Tang L, Chen H, Chen P, Chen D, Wang D.   +6 more
europepmc   +1 more source

Development of an SSR marker-based genetic linkage map and identification of a QTL associated with flowering time in Eustoma. [PDF]

Breed Sci, 2021
Kawakatsu K, Yagi M, Harada T, Yamaguchi H, Itoh T, Kumagai M, Itoh R, Numa H, Katayose Y, Kanamori H, Kurita K, Fukuta N.   +11 more
europepmc   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Construction of Simple Sequence Repeat-Based Genetic Linkage Map and Identification of QTLs for Accumulation of Floral Volatiles in Lavender (<i>Lavandula angustifolia</i> Mill.). [PDF]

Int J Mol Sci
Georgieva P, Rusanov K, Rusanova M, Kitanova M, Atanassov I.   +4 more
europepmc   +1 more source

Genotyping-by-Sequencing Derived Genetic Linkage Map and Quantitative Trait Loci for Sugar Content in Onion (Allium cepa L.). [PDF]

Plants (Basel), 2021
Lee YR, Kim CW, Han J, Choi HJ, Han K, Lee ES, Kim DS, Lee J, Siddique MI, Lee HE.   +9 more
europepmc   +1 more source