Results 191 to 200 of about 2,587,026 (311)

Exposing Selection and Genetic Linkage in the Evolutionary Enigmatic Balanced Lethal System in <i>Triturus</i> Newts. [PDF]

Ecol Evol
Meilink WRM, Cvijanović M, de Visser MC, France J, Ivanović A, Theodoropoulos A, Vučić T, Wielstra B.   +7 more
europepmc   +1 more source

QTL mapping for growth-related traits by constructing the first genetic linkage map in Simao pine. [PDF]

BMC Plant Biol, 2022
Wang D, Yang L, Shi C, Li S, Tang H, He C, Cai N, Duan A, Gong H.   +8 more
europepmc   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Genetic linkage disequilibrium of deleterious mutations in threatened mammals. [PDF]

EMBO Rep
Hu C, Liu G, Zhang Z, Pan Q, Zhang X, Liu W, Li Z, Li M, Zhu P, Ji T, Garber PA, Zhou X.   +11 more
europepmc   +1 more source

Analysis of the Genome Sequence of Strain GiC-126 of Gloeostereum incarnatum with Genetic Linkage Map. [PDF]

Mycobiology, 2021
Jiang WZ, Yao FJ, Fang M, Lu LX, Zhang YM, Wang P, Meng JJ, Lu J, Ma XX, He Q, Shao KS, Khan AA, Wei YH.   +12 more
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Genetic linkage map construction and QTL mapping for panicle-related traits in foxtail millet (<i>Setaria Italica</i> (L.) P. Beauv.). [PDF]

Mol Breed
Li H, Zhu Q, Wang T, Zhao Y, Fan J, Yang L, Wang S, Ma Y, Chen L, Li X, Dong S, Chu X, Yuan X, Wang J, Gao L, Yang G.   +15 more
europepmc   +1 more source

Close genetic linkage between human and companion animal extraintestinal pathogenic Escherichia coli ST127. [PDF]

Curr Res Microb Sci, 2022
Elankumaran P, Browning GF, Marenda MS, Reid CJ, Djordjevic SP.   +4 more
europepmc   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Timescale and genetic linkage explain the variable impact of defense systems on horizontal gene transfer. [PDF]

Genome Res
Liu Y, Botelho J, Iranzo J.
europepmc   +1 more source