Results 191 to 200 of about 342,848 (311)

Analysis of the Genome Sequence of Strain GiC-126 of Gloeostereum incarnatum with Genetic Linkage Map. [PDF]

Mycobiology, 2021
Jiang WZ, Yao FJ, Fang M, Lu LX, Zhang YM, Wang P, Meng JJ, Lu J, Ma XX, He Q, Shao KS, Khan AA, Wei YH.   +12 more
europepmc   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Genetic characterisation of post harvest spoilage in lettuce [PDF]

Post harvest discolouration in lettuce is an increasingly important problem due to the shift in the market for prepacked processed salads. Variation in post harvest discolouration was recorded in a lettuce diversity set of 28 accessions representative ...
Atkinson, Laura Denise
core  

Genetic linkage disequilibrium of deleterious mutations in threatened mammals. [PDF]

EMBO Rep
Hu C, Liu G, Zhang Z, Pan Q, Zhang X, Liu W, Li Z, Li M, Zhu P, Ji T, Garber PA, Zhou X.   +11 more
europepmc   +1 more source

Close genetic linkage between human and companion animal extraintestinal pathogenic Escherichia coli ST127. [PDF]

Curr Res Microb Sci, 2022
Elankumaran P, Browning GF, Marenda MS, Reid CJ, Djordjevic SP.   +4 more
europepmc   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Timescale and genetic linkage explain the variable impact of defense systems on horizontal gene transfer. [PDF]

Genome Res
Liu Y, Botelho J, Iranzo J.
europepmc   +1 more source

SNP-Based Genetic Linkage Map and Quantitative Trait Locus Mapping Associated with the Agronomically Important Traits of Hypsizygus marmoreus. [PDF]

Mycobiology, 2021
Oh YL, Choi IG, Jang KY, Kim MS, Oh MJ, Im JH.   +5 more
europepmc   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Construction of an ultrahigh-density genetic linkage map for Manihot esculenta Crantz and identification of QTL for root quantity traits. [PDF]

BMC Plant Biol
Liu Q, Li Z, Wang Z, Lu Y, Jiang S, Xia C, An P, Zhao L, Deng K, Xia Z, Wang W.   +10 more
europepmc   +1 more source