Results 231 to 240 of about 3,634,544 (343)

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Construction of an ultrahigh-density genetic linkage map for Manihot esculenta Crantz and identification of QTL for root quantity traits. [PDF]

BMC Plant Biol
Liu Q, Li Z, Wang Z, Lu Y, Jiang S, Xia C, An P, Zhao L, Deng K, Xia Z, Wang W.   +10 more
europepmc   +1 more source

QTL mapping and identification of genes associated with the resistance to Acanthoscelides obtectus in cultivated common bean using a high-density genetic linkage map. [PDF]

BMC Plant Biol, 2022
Li X, Tang Y, Wang L, Chang Y, Wu J, Wang S.   +5 more
europepmc   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Timescale and genetic linkage explain the variable impact of defense systems on horizontal gene transfer. [PDF]

Genome Res
Liu Y, Botelho J, Iranzo J.
europepmc   +1 more source

SNP-Based Genetic Linkage Map and Quantitative Trait Locus Mapping Associated with the Agronomically Important Traits of Hypsizygus marmoreus. [PDF]

Mycobiology, 2021
Oh YL, Choi IG, Jang KY, Kim MS, Oh MJ, Im JH.   +5 more
europepmc   +1 more source

THE ONE HUNDREDTH REPORT OF GENETICAL STUDIES ON RICE PLANT : Linkage Studies and Future Prospects

, 1991
Toshiro Kinoshita, Man-emon Takahashi
openalex   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Construction of a genetic linkage map and QTL mapping of the agronomic traits in Foxtail millet (Setaria italica). [PDF]

BMC Genomics
Gao L, Zhu Q, Li H, Wang S, Fan J, Wang T, Yang L, Zhao Y, Ma Y, Chen L, Li X, Dong S, Chu X, Diao X, Yuan X, Wang J, Yang G.   +16 more
europepmc   +1 more source

A High-Density Genetic Linkage Map and Fine Mapping of QTL For Feed Conversion Efficiency in Common Carp (Cyprinus carpio). [PDF]

Front Genet, 2021
Zhang X, Luan P, Cao D, Hu G.
europepmc   +1 more source