Results 251 to 260 of about 612,083 (305)

Optimizing exact genetic linkage computations

Proceedings of the seventh annual international conference on Research in computational molecular biology, 2003
Genetic linkage analysis is a challenging application which requires Bayesian networks consisting of thousands of vertices. Consequently, computing the probability of data, which is needed for learning linkage parameters, using exact computation procedures calls for an extremely efficient implementation that carefully optimizes the order of ...
Ma'ayan, Fishelson, Dan, Geiger
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Genetic Linkage and Hemochromatosis

New England Journal of Medicine, 1979
The two articles on hemochromatosis in this issue, by Beaumont and her colleagues from Rennes, France, and by Cartwright and his associates from Salt Lake City, Utah, show how genetic-linkage studi...
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C3 polymorphism: Genetic linkage relations

Clinical Genetics, 1974
Twenty‐one linkage relations of the C3 locus have been analyzed in Norwegian family material by means of the computer program MOSM. No suggestion of linkage was found. Excluding linkage intervals for which our data have reduced the probability of linkage by more than 95 %, it appears that in males, PGM1, Rh and ACP1 are not linked to C3 closer than TH –
T, Gedde-Dahl, P, Teisberg, E, Thorsby
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Genetic Linkage Studies

2006
Abstract This chapter describes the basic concepts and methods of genetic linkage studies. It first describes what linkage means and how investigators go about detecting linkage. It then discusses the causal paradigm of the genetic linkage study and contrasts linkage with association studies.
Ezra Susser, Sharon Schwartz, Alfredo Morabia, Evelyn J. Bromet   +3 more
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Genetic linkage.

British journal of hospital medicine, 1986
Not all doctors would understand the statement "linkage is now established between a DNA marker and the locus for adult polycystic kidney disease at a recombination fraction of 5%". Yet over the next few years increasing numbers of DNA markers linked to single-gene disorders will become available and clinicians will need to identify patients who could ...
J R, Yates, J M, Connor
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Linkage Analysis of Genetic Disorders

2003
Basic principles and methods of genetic analysis were covered in this chapter. The approaches of linkage analysis for Mendelian or complex disorders can be summarized in the following flowchart (Fig. 2). It is important that the clinical, analytical, and molecular investigators be involved in all steps in the process.
E W, Taylor, J, Xu, E W, Jabs, D A, Meyers   +3 more
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Gene linkage and genetic deafness

International Journal of Pediatric Otorhinolaryngology, 1995
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Cremers, C.W.R.J., Brown, S.D.M., Steel, K.P., Brunner, H.G., Read, A., Kimberling, W.J.   +5 more
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Bootstrapping in human genetic linkage

Annals of Human Genetics, 1994
SUMMARYLinkage analysis of discrete Mendelian traits has made a major contribution to the mapping of the human genome. However, in more complex situations, particularly Mendelian disorders showing locus heterogeneity, linkage results have sometimes been misleading.
M N, Chiano, J R, Yates
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Linkage tree genetic algorithm

Proceedings of the 12th annual conference companion on Genetic and evolutionary computation, 2010
We introduce the Linkage Tree Genetic Algorithm (LTGA), a competent genetic algorithm that learns the linkage between the problem variables. The LTGA builds each generation a linkage tree using a hierarchical clustering algorithm. To generate new offspring solutions, the LTGA selects two parent solutions and traverses the linkage tree starting from the
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Genetic Linkage in Bipolar Disorder

CNS Spectrums, 2003
AbstractBipolar disorder is an etiologically complex syndrome that is dearly heritable. Multiple, genes, working singly or in concert, are likely to cause susceptibility to bipolar disorder. Bipolar disorder genetics has progressed rapidly in the last few decades. However, specific causal genetic mutations for bipolar disorder have not been identified.
Carol A, Mathews, Victor I, Reus
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