Results 251 to 260 of about 2,587,026 (311)

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

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Genetic Linkage Studies

Lancet, The, 2005
Linkage analysis is used to map genetic loci by use of observations of related individuals. We provide an introduction to methods commonly used to map loci that predispose to disease. Linkage analysis methods can be applied to both major gene disorders (parametric linkage) and complex diseases (model-free or non-parametric linkage).
Jenny Barrett, Dawn Teare
exaly   +3 more sources

Writings on Genetic Linkage in the Annals

Annals of Human Genetics, 2011
SummaryFrom its inception in 1925 through the almost 30 years that it carried the title of Annals of Eugenics, this journal published numerous articles on the statistical aspects of genetic linkage analysis and its applications to family pedigree data. This overview discusses 40 papers on linkage analysis published in the Annals.
Ott, Jurg, Ott, J (reprint author), Chinese Acad Sci, Inst Psychol, 4A Datun Rd, Beijing 100101, Peoples R China.   +1 more
openaire   +3 more sources

Genetic Linkage Analysis in the Age of Whole-Genome Sequencing

Nature Reviews Genetics, 2015
For many years, linkage analysis was the primary tool used for the genetic mapping of Mendelian and complex traits with familial aggregation. Linkage analysis was largely supplanted by the wide adoption of genome-wide association studies (GWASs). However,
Jürg Ott, Suzanne M. Leal
exaly   +1 more source

Tests for Genetic Linkage and Homogeneity

Biometrics, 1995
This report concerns likelihood ratio tests in a heterogeneous model for linkage, where the recombination fraction has a binomial mixture distribution with an unknown proportion of unlinked families. We consider families of unequal sizes with known or unknown phase data.
Lemdani, M., Pons, O.
openaire   +4 more sources

Genetic Linkage and Hemochromatosis

New England Journal of Medicine, 1979
The two articles on hemochromatosis in this issue, by Beaumont and her colleagues from Rennes, France, and by Cartwright and his associates from Salt Lake City, Utah, show how genetic-linkage studi...
openaire   +2 more sources

A genetic linkage study of choroideremia

Ophthalmic Paediatrics and Genetics, 1986
One hundred and twenty-two members of 15 choroideremia families have been used in a genetic linkage study of choroideremia (TCD) using four DNA probes situated on the X chromosome. Linkage was analysed using DNA probes DXS14 (p58-1), DXYS1 (pDP 34), DXS178 (p212) and DXS177 (lambda 2.7).
M, Jay, A F, Wright, J F, Clayton, M, Deans, M, Dempster, S S, Bhattacharya, B, Jay   +6 more
openaire   +3 more sources

Linkage equilibrium and genetic algorithms

Proceedings of 1997 IEEE International Conference on Evolutionary Computation (ICEC '97), 2002
The mathematical analysis of recombination/crossover in population genetics and genetic algorithms is very difficult. We investigate a result from H. Geiringer (1944), which states that by repeated applications of the recombination operator alone (with no selective pressure) the gene frequencies of diploid organisms converge to linkage equilibrium. The
Uday Kumar Chakraborty, Heinz Mühlenbein   +1 more
openaire   +2 more sources

A Genetic Linkage Map for the Zebrafish

Science, 1994
To facilitate molecular genetic analysis of vertebrate development, haploid genetics was used to construct a recombination map for the zebrafish Danio ( Brachydanio ) rerio .
John H. Postlethwait, Stephen L. Johnson, Clare N. Midson, William S. Talbot, Michael Gates, Eric W. Ballinger, Dana Africa, Rebecca Andrews, Tim Carl, Judith S. Eisen, Sally Horne, Charles B. Kimmel, Mark Hutchinson, Michele Johnson, Andre Rodriguez   +14 more
openaire   +2 more sources