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Introduction to Genetic Linkage Analysis
Cancer Investigation, 1997Advances in molecular methodology have resulted in the successful genetic mapping and isolation of the genes responsible for numerous simple Mendelian disorders such as cystic fibrosis, neurofibromatosis, and Huntington disease. Recently, researchers have begun to successfully study diseases with more complex inheritance, such as breast cancer.
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Genetic hemochromatosis and HLA linkage
Human Genetics, 1987We previously reported five families with primary, genetic (idiopathic) hemochromatosis in whom HLA typing of subjects indicated that a homozygous-heterozygous mating had almost certainly occurred and in whom inheritance of the disease trait was best explained by an autosomal recessive mode of inheritance.
Powell, Lawrie W. +5 more
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Genetic linkage in the Norway rat
Genetica, 1987The present status of research on genetic linkage is reviewed. Where possible, the data are statistically combined to give consolidated estimates of the recombination value. Ten groups of linked genes have been determined. The first assignments of linkage groups to specific chromosomes have been facilitated by inter-species cell hybridisation.
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The Linkage Tree Genetic Algorithm
2010We introduce the Linkage Tree Genetic Algorithm (LTGA), a competent genetic algorithm that learns the linkage between the problem variables. The LTGA builds each generation a linkage tree using a hierarchical clustering algorithm. To generate new offspring solutions, the LTGA selects two parent solutions and traverses the linkage tree starting from the
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Genetic Linkage in Neurologic Diseases
New England Journal of Medicine, 1987Until recently, the hope of identifying genes associated with dominant inherited neurologic disorders seemed remote. Now that has changed. The powerful techniques of molecular biology have provided methods for locating, by linkage analysis, the genes responsible for several of these diseases and for using the same techniques for presymptomatic or ...
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The Search for Genetic Linkage in Schizophrenia
British Journal of Psychiatry, 1982Enormous industry has been devoted during the last half-century to establishing the genetic contribution to the aetiology of schizophrenia. Demonstration of a familial concentration of the disorder among the blood relatives of schizophrenics is supported by the differential concordance for schizophrenia found between monozygotic and dizygotic twins ...
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Genetic Algorithm with Linkage Learning
Proceedings of the Genetic and Evolutionary Computation Conference, 2023Renato Tinós +3 more
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Genetic Testing in Prostate Cancer Management: Considerations Informing Primary Care
Ca-A Cancer Journal for Clinicians, 2022Todd M Morgan +2 more
exaly
MPL Resolves Genetic Linkage in Fitness Inference From Complex Evolutionary Histories
Nature Biotechnology, 2021Matthew R McKay +2 more
exaly
Approaches to Genetic Linkage Analysis
2010Genetic linkage analysis concerns the estimation of genetic distance between two or more genetic loci. In genetic epidemiology, it is predominantly used to identify, or map, a genetic locus that is associated with quantitative trait variation or, in the case of binary or discrete traits, modification of the risk of being affected with a disease or ...
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