Results 261 to 270 of about 2,587,026 (311)
Some of the next articles are maybe not open access.
Genetic Linkage in Bipolar Disorder
CNS Spectrums, 2003AbstractBipolar disorder is an etiologically complex syndrome that is dearly heritable. Multiple, genes, working singly or in concert, are likely to cause susceptibility to bipolar disorder. Bipolar disorder genetics has progressed rapidly in the last few decades. However, specific causal genetic mutations for bipolar disorder have not been identified.
Carol A, Mathews, Victor I, Reus
openaire +2 more sources
Linkage Analysis of Genetic Disorders
2003Basic principles and methods of genetic analysis were covered in this chapter. The approaches of linkage analysis for Mendelian or complex disorders can be summarized in the following flowchart (Fig. 2). It is important that the clinical, analytical, and molecular investigators be involved in all steps in the process.
E W, Taylor +3 more
openaire +2 more sources
Genetics and linkage analysis on phosphoglucomutase
Humangenetik, 1971The current study is based on 454 families with 843 children from two different areas in Western Germany (Marburg and Tfibingen). Only families which have been especially ascertained for these investigations have been taken into account. For the estimation of the gene frequencies 1449 unrelated persons from the areas mentioned above were investigated ...
G G, Wendt +6 more
openaire +2 more sources
British journal of hospital medicine, 1986
Not all doctors would understand the statement "linkage is now established between a DNA marker and the locus for adult polycystic kidney disease at a recombination fraction of 5%". Yet over the next few years increasing numbers of DNA markers linked to single-gene disorders will become available and clinicians will need to identify patients who could ...
J R, Yates, J M, Connor
openaire +1 more source
Not all doctors would understand the statement "linkage is now established between a DNA marker and the locus for adult polycystic kidney disease at a recombination fraction of 5%". Yet over the next few years increasing numbers of DNA markers linked to single-gene disorders will become available and clinicians will need to identify patients who could ...
J R, Yates, J M, Connor
openaire +1 more source
Software for genetic linkage analysis
Molecular Biotechnology, 1996Recent developments in human genetic linkage analysis have included the appearance of new software and collections of data and program resources, accessible by means of the Internet. Many of these new programs and collections are described, including their availability, literature background, and specific technical information.
openaire +3 more sources
Bootstrapping in human genetic linkage
Annals of Human Genetics, 1994SUMMARYLinkage analysis of discrete Mendelian traits has made a major contribution to the mapping of the human genome. However, in more complex situations, particularly Mendelian disorders showing locus heterogeneity, linkage results have sometimes been misleading.
M N, Chiano, J R, Yates
openaire +2 more sources
A study of genetic linkage in schizophrenia
Psychological Medicine, 1987SynopsisFamilies with more than one member affected by schizophrenia were identified and their members were interviewed. Four standardized diagnostic definitions (PSE, DSM-III, ICD-9, Feighner) were applied to all subjects who were classified as schizophrenic or not schizophrenic according to each definition.
B, Andrew +3 more
openaire +2 more sources
Linkage and Association to Genetic Markers
2015Genetic markers that are sufficiently polymorphic (as measured by their heterozygosities) can be used in linkage and association analyses to detect Mendelian segregation underlying disease phenotypes. Each type of analysis can either be based on a specific genetic model or not make any assumptions about the mode of inheritance of the disease ...
openaire +2 more sources
The Use of Linkage in Genetic Counselling
Human Heredity, 1970Methods are outlined for incorporating information from genetical linkage in the prediction of genotypes, for discrimination of genetic entities, for advice to adults, and for antenatal diagnosis ...
openaire +2 more sources
Gene linkage and genetic deafness
International Journal of Pediatric Otorhinolaryngology, 1995Item does not contain ...
Cremers, C.W.R.J. +5 more
openaire +6 more sources