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Linkage Analysis of Genetic Disorders
2003Basic principles and methods of genetic analysis were covered in this chapter. The approaches of linkage analysis for Mendelian or complex disorders can be summarized in the following flowchart (Fig. 2). It is important that the clinical, analytical, and molecular investigators be involved in all steps in the process.
Jianfeng Xu +3 more
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Estimation of Genetic Linkage: An Outline
Methods of Information in Medicine, 1966Genes carried on the same chromosome pair are said to be »linked«. For the most part this interferes with their independent assortment. The probability that two genes on the same chromosome part company during hereditary transmission is the recombination value (χ); in man it ranges from zero (corresponding to pleiotropy) to 0.5 (independent assortment).
R W Sherwin, E A Murphy
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An Integrated Genetic Linkage Map of the Soybean Genome
, 1999A number of molecular genetic maps of the soybean [Glycine max (L.) Merr.] have been developed over the past 10 yr. These maps are primarily based on restriction fragment length polymorphism (RFLP) markers. Parental surveys have shown that most RFLP loci
P. Cregan +10 more
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Genetic linkage in the Norway rat [PDF]
Genetica, 1987 The present status of research on genetic linkage is reviewed. Where possible, the data are statistically combined to give consolidated estimates of the recombination value. Ten groups of linked genes have been determined. The first assignments of linkage groups to specific chromosomes have been facilitated by inter-species cell hybridisation.
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Handbook of Human Genetic Linkage
, 1994In his book "Analysis of Human Genetic Linkage" Jurg Ott laid out the principles by which geneticists perform studies of genetic linkage in humans. Here, in the "Handbook of Human Genetic Linkage", Joseph Terwilliger and Jurg Ott provide a companion ...
J. Terwilliger, J. Ott
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Genetic Linkage in Bipolar Disorder
CNS Spectrums, 2003AbstractBipolar disorder is an etiologically complex syndrome that is dearly heritable. Multiple, genes, working singly or in concert, are likely to cause susceptibility to bipolar disorder. Bipolar disorder genetics has progressed rapidly in the last few decades. However, specific causal genetic mutations for bipolar disorder have not been identified.
Victor I. Reus, Carol A. Mathews
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Genetics and linkage analysis on phosphoglucomutase
Humangenetik, 1971The current study is based on 454 families with 843 children from two different areas in Western Germany (Marburg and Tfibingen). Only families which have been especially ascertained for these investigations have been taken into account. For the estimation of the gene frequencies 1449 unrelated persons from the areas mentioned above were investigated ...
G. Tariverdian +6 more
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2010
Ikeda et al. performed a genome-wide linkage study using 16 Japanese families with moyamoya disease and 371 microsatellite markers [1]. In the study 13 of 16 families had sibling cases and the rest of them included parent—children transmission of the disease. Maximum nonparametric linkage (NPL) score of 3.4 was found at the marker D3S3050. NPL score of
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Ikeda et al. performed a genome-wide linkage study using 16 Japanese families with moyamoya disease and 371 microsatellite markers [1]. In the study 13 of 16 families had sibling cases and the rest of them included parent—children transmission of the disease. Maximum nonparametric linkage (NPL) score of 3.4 was found at the marker D3S3050. NPL score of
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The Search for Genetic Linkage in Schizophrenia
British Journal of Psychiatry, 1982Enormous industry has been devoted during the last half-century to establishing the genetic contribution to the aetiology of schizophrenia. Demonstration of a familial concentration of the disorder among the blood relatives of schizophrenics is supported by the differential concordance for schizophrenia found between monozygotic and dizygotic twins ...
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