Results 261 to 270 of about 283,128 (311)

Genetic Linkage and Hemochromatosis

New England Journal of Medicine, 1979
The two articles on hemochromatosis in this issue, by Beaumont and her colleagues from Rennes, France, and by Cartwright and his associates from Salt Lake City, Utah, show how genetic-linkage studi...
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A study of genetic linkage in schizophrenia

Psychological Medicine, 1987
SynopsisFamilies with more than one member affected by schizophrenia were identified and their members were interviewed. Four standardized diagnostic definitions (PSE, DSM-III, ICD-9, Feighner) were applied to all subjects who were classified as schizophrenic or not schizophrenic according to each definition.
C. Gillespie, David C. Watt, B. Andrew, H. Chapel   +3 more
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Writings on Genetic Linkage in the Annals

Annals of Human Genetics, 2011
SummaryFrom its inception in 1925 through the almost 30 years that it carried the title of Annals of Eugenics, this journal published numerous articles on the statistical aspects of genetic linkage analysis and its applications to family pedigree data. This overview discusses 40 papers on linkage analysis published in the Annals.
Jurg Ott, Jurg Ott
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A Genetic Linkage Map for the Zebrafish

Science, 1994
To facilitate molecular genetic analysis of vertebrate development, haploid genetics was used to construct a recombination map for the zebrafish Danio ( Brachydanio ) rerio .
Clare N. Midson, Andre Rodriguez, Mark Hutchinson, Sally Horne, John H. Postlethwait, Charles B. Kimmel, Judith S. Eisen, Rebecca Andrews, Dana Africa, Michele Johnson, Tim Carl, Eric W. Ballinger, Michael A. Gates, Stephen L. Johnson, William S. Talbot   +14 more
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Linkage Analysis of Genetic Disorders

2003
Basic principles and methods of genetic analysis were covered in this chapter. The approaches of linkage analysis for Mendelian or complex disorders can be summarized in the following flowchart (Fig. 2). It is important that the clinical, analytical, and molecular investigators be involved in all steps in the process.
Jianfeng Xu, Deborah A. Meyers, Ethylin Wang Jabs, Eugene W. Taylor   +3 more
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Bootstrapping in human genetic linkage

Annals of Human Genetics, 1994
SUMMARYLinkage analysis of discrete Mendelian traits has made a major contribution to the mapping of the human genome. However, in more complex situations, particularly Mendelian disorders showing locus heterogeneity, linkage results have sometimes been misleading.
J. R. W. Yates, M. N. Chiano
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Estimation of Genetic Linkage: An Outline

Methods of Information in Medicine, 1966
Genes carried on the same chromosome pair are said to be »linked«. For the most part this interferes with their independent assortment. The probability that two genes on the same chromosome part company during hereditary transmission is the recombination value (χ); in man it ranges from zero (corresponding to pleiotropy) to 0.5 (independent assortment).
R W Sherwin, E A Murphy
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Genetic linkage in the Norway rat [PDF]

Genetica, 1987
The present status of research on genetic linkage is reviewed. Where possible, the data are statistically combined to give consolidated estimates of the recombination value. Ten groups of linked genes have been determined. The first assignments of linkage groups to specific chromosomes have been facilitated by inter-species cell hybridisation.
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Genetic Linkage in Bipolar Disorder

CNS Spectrums, 2003
AbstractBipolar disorder is an etiologically complex syndrome that is dearly heritable. Multiple, genes, working singly or in concert, are likely to cause susceptibility to bipolar disorder. Bipolar disorder genetics has progressed rapidly in the last few decades. However, specific causal genetic mutations for bipolar disorder have not been identified.
Victor I. Reus, Carol A. Mathews
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The Search for Genetic Linkage in Schizophrenia

British Journal of Psychiatry, 1982
Enormous industry has been devoted during the last half-century to establishing the genetic contribution to the aetiology of schizophrenia. Demonstration of a familial concentration of the disorder among the blood relatives of schizophrenics is supported by the differential concordance for schizophrenia found between monozygotic and dizygotic twins ...
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