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Genetics and linkage analysis on phosphoglucomutase
Humangenetik, 1971The current study is based on 454 families with 843 children from two different areas in Western Germany (Marburg and Tfibingen). Only families which have been especially ascertained for these investigations have been taken into account. For the estimation of the gene frequencies 1449 unrelated persons from the areas mentioned above were investigated ...
G. Tariverdian +6 more
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2010
Ikeda et al. performed a genome-wide linkage study using 16 Japanese families with moyamoya disease and 371 microsatellite markers [1]. In the study 13 of 16 families had sibling cases and the rest of them included parent—children transmission of the disease. Maximum nonparametric linkage (NPL) score of 3.4 was found at the marker D3S3050. NPL score of
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Ikeda et al. performed a genome-wide linkage study using 16 Japanese families with moyamoya disease and 371 microsatellite markers [1]. In the study 13 of 16 families had sibling cases and the rest of them included parent—children transmission of the disease. Maximum nonparametric linkage (NPL) score of 3.4 was found at the marker D3S3050. NPL score of
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Genetic hemochromatosis and HLA linkage
Human Genetics, 1987We previously reported five families with primary, genetic (idiopathic) hemochromatosis in whom HLA typing of subjects indicated that a homozygous-heterozygous mating had almost certainly occurred and in whom inheritance of the disease trait was best explained by an autosomal recessive mode of inheritance.
Powell, Lawrie W. +5 more
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A genetic linkage map of eggplant
2000International ...
Doganlar, S. +4 more
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Crop Science, 2002
Mapping mutants of classical linkage groups 6 and 8 (CLGs 6 and 8) in soybean [Glycine max (L.) Merr.] can enhance the identification of important agronomic traits. Genetic data suggest that CLGs 6 and 8 may belong to the same linkage group. Our objectives were to determine if CLGs 6 and 8 are the same or different linkage groups and to determine the ...
A. Assibi Mahama +2 more
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Mapping mutants of classical linkage groups 6 and 8 (CLGs 6 and 8) in soybean [Glycine max (L.) Merr.] can enhance the identification of important agronomic traits. Genetic data suggest that CLGs 6 and 8 may belong to the same linkage group. Our objectives were to determine if CLGs 6 and 8 are the same or different linkage groups and to determine the ...
A. Assibi Mahama +2 more
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The Use of Linkage in Genetic Counselling
Human Heredity, 1970Methods are outlined for incorporating information from genetical linkage in the prediction of genotypes, for discrimination of genetic entities, for advice to adults, and for antenatal diagnosis ...
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Linkage and Association to Genetic Markers
2015Genetic markers that are sufficiently polymorphic (as measured by their heterozygosities) can be used in linkage and association analyses to detect Mendelian segregation underlying disease phenotypes. Each type of analysis can either be based on a specific genetic model or not make any assumptions about the mode of inheritance of the disease ...
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Introduction to Genetic Linkage Analysis
Cancer Investigation, 1997Advances in molecular methodology have resulted in the successful genetic mapping and isolation of the genes responsible for numerous simple Mendelian disorders such as cystic fibrosis, neurofibromatosis, and Huntington disease. Recently, researchers have begun to successfully study diseases with more complex inheritance, such as breast cancer.
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Genetic Linkage in Neurologic Diseases
New England Journal of Medicine, 1987Until recently, the hope of identifying genes associated with dominant inherited neurologic disorders seemed remote. Now that has changed. The powerful techniques of molecular biology have provided methods for locating, by linkage analysis, the genes responsible for several of these diseases and for using the same techniques for presymptomatic or ...
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