Genetic Linkage Analysis [PDF]
Archives of Neurology, 1999 Genetic linkage analysis is a powerful tool to detect the chromosomal location of disease genes. It is based on the observation that genes that reside physically close on a chromosome remain linked during meiosis. For most neurologic diseases for which the underlying biochemical defect was not known, the identification of the chromosomal location of ...
openaire +3 more sources
Deciphering the mystery of CHNG3 [PDF]
Annals of Pediatric Endocrinology & MetabolismCongenital hypothyroidism (CH), characterized by insufficient thyroid hormone production due to abnormalities in the hypothalamic-pituitary-thyroid axis, is the most common congenital endocrine disorder.
Satoshi Narumi
doaj +1 more source
Genome-wide linkage scan for loci associated with epilepsy in Belgian shepherd dogs. [PDF]
, 2010 BackgroundIdiopathic epilepsy in the Belgian shepherd dog is known to have a substantial genetic component. The objective of this study was to identify genomic regions associated with the expression of generalized seizures in the Belgian Tervuren and ...
Belanger, Janelle M +4 more
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A saturated genetic linkage map of autotetraploid alfalfa (Medicago sativa L.) developed using genotyping-by-sequencing is highly syntenous with the Medicago truncatula genome. [PDF]
, 2014 A genetic linkage map is a valuable tool for quantitative trait locus mapping, map-based gene cloning, comparative mapping, and whole-genome assembly. Alfalfa, one of the most important forage crops in the world, is autotetraploid, allogamous, and highly
Acharya, Ananta +5 more
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Construction of Genetic Linkage Map of Plum (Prunus salicina L.) with ISSR and SRAP Markers
Guangdong nongye kexue, 2022 【Objective】Plum (Prunus salicina L.) is a tree species with great economic prospect in northeast China, and it has important social and economic values. Genetic linkage maps of plum were constructed by molecular markers to provide a theoretical basis for
Lili SUN +4 more
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BMC Genomics, 2016 A landmark in soybean research, Glyma1.01, the first whole genome sequence of variety Williams 82 (Glycine max L. Merr.) was completed in 2010 and is widely used.
Q. Song +7 more
semanticscholar +1 more source
Tapasin gene polymorphism in systemic onset juvenile rheumatoid arthritis: a family-based case-control study [PDF]
, 2005 Juvenile rheumatoid arthritis (JRA) comprises a group of chronic systemic inflammatory disorders that primarily affect joints and can cause long-term disability.
Bukulmez, H +9 more
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Plant Biotechnology Journal, 2017 Summary Agropyron Gaertn. (P genome) is a wild relative of wheat that harbours many genetic variations that could be used to increase the genetic diversity of wheat.
Shenghui Zhou +9 more
semanticscholar +1 more source
Mapping genes through the use of linkage disequilibrium generated by genetic drift: 'Drift mapping' in small populations with no demographic expansion [PDF]
, 1998 Linkage disequilibrium has been a powerful tool in identifying rare disease alleles in human populations. To date, most research has been directed to isolated populations which have undergone a bottleneck followed by rapid exponential expansion.
Laan, Maris +3 more
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High-density SNP association study of the 17q21 chromosomal region linked to autism identifies CACNA1G as a novel candidate gene. [PDF]
, 2009 Chromosome 17q11-q21 is a region of the genome likely to harbor susceptibility to autism (MIM(209850)) based on earlier evidence of linkage to the disorder.
Cantor, RM +6 more
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