Results 31 to 40 of about 612,083 (305)

Mapping genes through the use of linkage disequilibrium generated by genetic drift: 'Drift mapping' in small populations with no demographic expansion [PDF]

, 1998
Linkage disequilibrium has been a powerful tool in identifying rare disease alleles in human populations. To date, most research has been directed to isolated populations which have undergone a bottleneck followed by rapid exponential expansion.
Laan, Maris, Pääbo, Svante, Terwilliger, Joseph D., Zöllner, Sebastian   +3 more
core   +1 more source

Meta-Analysis of Genome-Wide Linkage Studies in Celiac Disease. [PDF]

, 2009
OBJECTIVE: A meta-analysis of genome-wide linkage studies allows us to summarize the extensive information available from family-based studies, as the field moves into genome-wide association studies. METHODS: Here we apply the genome scan meta-analysis
Babron MC, Ciclitira PJ, Forabosco P, GRECO, LUIGI, Houlston RS, Lewis C.M., Naluai AT, Neuhausen SL, Saavalainen P, Wijmenga C   +9 more
core   +1 more source

Regional differences in recombination hotspots between two chicken populations [PDF]

, 2010
Background Although several genetic linkage maps of the chicken genome have been published, the resolution of these maps is limited and does not allow the precise identification of recombination hotspots. The availability of more than 3.2 million SNPs in
Martin G Elferink, Pieter van As, Tineke Veenendaal, Richard PMA Crooijmans, Martien AM Groenen, EW Daw, A Kong, X Kong, TC Matise, S Shifman, The STAR Consortium, MAM Groenen, N Bumstead, JW Wallis, L Jacobsson, S Kerje, MAM Groenen, International Chicken Genome Sequencing Consortium, HH Cheng, M Schmid, DW Burt, International Chicken Genome Sequencing Consortium, A Pakdel, AM Closter, TSKM Rabie, D Jennen, JBC van Kaam, JBC van Kaam, P Wahlberg   +28 more
core   +2 more sources

Quantitative trait loci influencing low density lipoprotein particle size in African Americans

Journal of Lipid Research, 2006
Genomic regions that influence LDL particle size in African Americans are not known. We performed family-based linkage analyses to identify genomic regions that influence LDL particle size and also exert pleiotropic effects on two closely related lipid ...
Iftikhar J. Kullo, Keyue Ding, Eric Boerwinkle, Stephen T. Turner, Mariza de Andrade   +4 more
doaj   +1 more source

Genetic linkage and molecular evolution [PDF]

Current Biology, 2001
The different models make similar predictions which makes it difficult to ascribe an observation to just one process. Are there any observations that allow one to identify which process is operating? It turns out that the distribution of frequencies of neu-tral variants in a sample of sequences (the frequency spectrum) is model-dependent.
Gordo, Isabel, Charlesworth, Brian
openaire   +2 more sources

New technologies for delineating and characterizing the lipid exome: prospects for understanding familial combined hyperlipidemia

Journal of Lipid Research, 2009
This review summarizes the progress made in cutting through the biological and genetic complexity of the Gordian knot that is familial combined hyperlipidemia. We particularly focus on how the application of new genomic technologies, especially massively
Stuart D. Horswell, Helen E. Ringham, Carol C. Shoulders   +2 more
doaj   +1 more source

A new genome scan for primary nonsyndromic vesicoureteric reflux emphasizes high genetic heterogeneity and shows linkage and association with various genes already implicated in urinary tract development

Molecular Genetics & Genomic Medicine, 2014
Primary vesicoureteric reflux (VUR), the retrograde flow of urine from the bladder toward the kidneys, results from a developmental anomaly of the vesicoureteric valve mechanism, and is often associated with other urinary tract anomalies.
J. M. Darlow, M. G. Dobson, R. Darlay, C. M. Molony, M. Hunziker, A. J. Green, H. J. Cordell, P. Puri, D. E. Barton   +8 more
doaj   +1 more source

Annotated genetic linkage maps of Pinus pinaster Ait. from a Central Spain population using microsatellite and gene based markers

BMC Genomics, 2012
Background Pinus pinaster Ait. is a major resin producing species in Spain. Genetic linkage mapping can facilitate marker-assisted selection (MAS) through the identification of Quantitative Trait Loci and selection of allelic variants of interest in ...
de Miguel Marina, de Maria Nuria, Guevara M, Diaz Luis, Sáez-Laguna Enrique, Sánchez-Gómez David, Chancerel Emilie, Aranda Ismael, Collada Carmen, Plomion Christophe, Cabezas José-Antonio, Cervera María-Teresa   +11 more
doaj   +1 more source

Genomic Resource Development for Hydrangea (Hydrangea macrophylla (Thunb.) Ser.)—A Transcriptome Assembly and a High-Density Genetic Linkage Map

Horticulturae, 2021
Hydrangea (Hydrangea macrophylla) is an important ornamental crop that has been cultivated for more than 300 years. Despite the economic importance, genetic studies for hydrangea have been limited by the lack of genetic resources.
Xingbo Wu, Amanda M. Hulse-Kemp, Phillip A. Wadl, Zach Smith, Keithanne Mockaitis, Margaret E. Staton, Timothy A. Rinehart, Lisa W. Alexander   +7 more
doaj   +1 more source

High-density SNP genetic linkage map construction and quantitative trait locus mapping for resistance to cucumber mosaic virus in tobacco (Nicotiana tabacum L.)

Crop Journal, 2019
Genetic linkage maps are essential for studies of genetics, genomic structure, and genomic evolution, and for mapping quantitative trait loci (QTL).
Lirui Cheng, Xiaocui Chen, Caihong Jiang, Bing Ma, Min Ren, Yazeng Cheng, Dan Liu, Ruimei Geng, Aiguo Yang   +8 more
doaj   +1 more source