Results 51 to 60 of about 3,191,200 (316)

Modeling Homophily in Dynamic Networks with Application to HIV Molecular Surveillance [PDF]

arXiv, 2021
This paper describes a novel approach to modeling homphily, i.e. the tendency of nodes that share (or differ in) certain attributes to be linked; we consider dynamic networks in which nodes can be added over time but not removed. Our application is to HIV genetic linkage analysis that has been used to investigate HIV transmission dynamics.
arxiv  

Robust Tests in Genome-Wide Scans under Incomplete Linkage Disequilibrium [PDF]

Statistical Science 2009, Vol. 24, No. 4, 503-516, 2010
Under complete linkage disequilibrium (LD), robust tests often have greater power than Pearson's chi-square test and trend tests for the analysis of case-control genetic association studies. Robust statistics have been used in candidate-gene and genome-wide association studies (GWAS) when the genetic model is unknown.
arxiv   +1 more source

What does it take to evolve behaviorally complex organisms? [PDF]

, 2001
What genotypic features explain the evolvability of organisms that have to accomplish many different tasks? The genotype of behaviorally complex organisms may be more likely to encode modular neural architectures because neural modules dedicated to ...
Calabretta, Raffaele, Di Ferdinando, Andrea, Parisi, Domenico, Wagner, Günter P.   +3 more
core  

Characteristics of the Kelch domain containing (KLHDC) subfamily and relationships with diseases

FEBS Letters, EarlyView.
The Kelch protein superfamily includes 63 members, with the KLHDC subfamily having 10 proteins. While their functions are not fully understood, recent advances in KLHDC2's structure and role in protein degradation have highlighted its potential for drug development, especially in PROTAC therapies.
Courtney Pilcher, Paula Armina V. Buco, Jia Q. Truong, Paul A. Ramsland, Monique F. Smeets, Carl R. Walkley, Jessica K. Holien   +6 more
wiley   +1 more source

The multiple roles of the NlpC_P60 peptidase family in mycobacteria – an underexplored target for antimicrobial drug discovery

FEBS Letters, EarlyView.
The NlpC_P60 superfamily of peptidases is recognised by its key role in bacterial cell wall homeostasis. Recently, studies have also described the involvement of NlpC_P60‐like enzymes in bacterial competitive mechanisms and pathogenesis across several lineages.
Catharina dos Santos Silva, Marcio Vinicius Bertacine Dias   +1 more
wiley   +1 more source

Construction of high-density genetic linkage maps for orange-spotted grouper Epinephelus coioides using multiplexed shotgun genotyping

BMC Genetics, 2013
BackgroundOrange-spotted grouper, Epinephelus coioides, is one of the most valuable fish species in China. Commercial production of orange-spotted grouper could be increased by developing higher growth rates and improving commercially important traits ...
Xinxin You, Li Shu, Shuisheng Li, Jieming Chen, Jian Luo, Jun Lu, Qian Mu, Jie Bai, Qiuju Xia, Qingchun Chen, Yanjie Cai, Haifa Zhang, Guohua Chen, Hao-ran Lin, Yong Zhang, Qiong Shi   +15 more
semanticscholar   +1 more source

Making tau amyloid models in vitro: a crucial and underestimated challenge

FEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

Construction of a reference genetic linkage map for carnation (Dianthus caryophyllus L.)

BMC Genomics, 2013
BackgroundGenetic linkage maps are important tools for many genetic applications including mapping of quantitative trait loci (QTLs), identifying DNA markers for fingerprinting, and map-based gene cloning.
M. Yagi, Toshiya Yamamoto, S. Isobe, H. Hirakawa, S. Tabata, K. Tanase, H. Yamaguchi, T. Onozaki   +7 more
semanticscholar   +1 more source

Unraveling Mycobacterium tuberculosis acid resistance and pH homeostasis mechanisms

FEBS Letters, EarlyView.
Mycobacterium tuberculosis exhibits a remarkable resilience to acid stress. In this Review, we discuss some of the molecular mechanisms and metabolic pathways used by the tubercle bacilli to adapt and resist host‐mediated acid stress. Mycobacterium tuberculosis (Mtb) is a successful pathogen that has developed a variety of strategies to survive and ...
Janïs Laudouze, Stéphane Canaan, Alexandre Gouzy, Pierre Santucci   +3 more
wiley   +1 more source

Genome-wide linkage analysis of 972 bipolar pedigrees using single-nucleotide polymorphisms. [PDF]

, 2011
Because of the high costs associated with ascertainment of families, most linkage studies of Bipolar I disorder (BPI) have used relatively small samples. Moreover, the genetic information content reported in most studies has been less than 0.6.
A Kong, A MacLean, A Serretti, AE Baum, AJ Jasinska, AL Price, BK Suarez, BL Browning, C-Y Liu, D Blackwood, D Grozeva, D Grozeva, D Koller, D Lambert, D Morris, D Sadovnick, D Zhang, DH Blackwood, DL Pauls, E Green, E Green, E S Gershon, EM Wijsman, EN Smith, ER Hauser, ET Cirulli, F J McMahon, F Mathieu, G J Lyon, G Kirov, GR Abecasis, H Coon, H Edenberg, HJ Edenberg, HM Ollila, I Jones, J A Badner, J B Potash, J Fan, J I Nurnberger, J Kelsoe, J Ross, JI Nurnberger, JM Ekholm, JPA Ioannidis, JR Kelsoe, JR O’Connell, KA Frazer, KR Merikangas, KY Liang, L Jones, LJ Adams, LJ Scott, M Ayub, M Gill, M Hamshere, MA Spence, MAR Ferreira, MB McQueen, MS McPeek, N Craddock, P Keck, P P Zandi, P Sklar, PP Zandi, R Remick, R Robinson, R Segurado, S Macgregor, S Purcell, SA Bacanu, T Foroud, T Venken, TC Matise, V L Willour, W Byerley, W McMahon, WH Berrettini, WTCC Consortium   +78 more
core   +3 more sources