Results 71 to 80 of about 342,848 (311)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Linkage evidence and methylation at 2q region in nonsyndromic cleft lip and/or palate of Malay population

Journal of Cleft Lip Palate and Craniofacial Anomalies, 2017
Introduction: Nonsyndromic cleft lip and/or palate (NSCLP) occurs as a result of multifactorial determinants, involving both genetic and environmental factors.
Nurul Syazana Mohamad Shah, Sarina Sulong, Wan Azman Wan Sulaiman, Ahmad Sukari Halim   +3 more
doaj   +1 more source

A high-density genetic map construction and sex-related loci identification in Chinese Giant salamander

BMC Genomics, 2021
Background The Chinese giant salamander Andrias davidianus is an important amphibian species in China because of its increasing economic value, protection status and special evolutionary position from aquatic to terrestrial animal.
Qiaomu Hu, Yang Liu, Xiaolin Liao, Haifeng Tian, Xiangshan Ji, Jiajie Zhu, Hanbing Xiao   +6 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

A genome-wide search replicates evidence of a quantitative trait locus for circulating angiotensisn l-converting enzyme (ACE) unlinked to the ACE gene [PDF]

, 2008
Background: angiotensin I-converting enzyme (ACE) plays an important role in cardiovascular homeostasis. There is evidence from different ethnic groups that circulating ACE levels are influenced by a quantitative trait locus (QTL) at the ACE gene on ...
Amy Luke, Zhu, Xiaofeng, Xiaofeng Zhu, Terrence E Forrester, Forrester, Terrence E., Nourdine Bouzekri, Cooper, Richard S., Bouzekri Nourdine, Colin A McKenzie, McKenzie, Coiln A., Forrester Terrence E, Zhu Xiaofeng, McKenzie Colin A, Adeyemo, Adebowale A., Luke Amy, Bouzekri, Nourdine, Cooper Richard S, Richard S Cooper, Luke, Amy, Adebowale A Adeyemo, Adeyemo Adebowale A   +20 more
core   +1 more source

Highly localized divergence within supergenes in Atlantic cod (Gadus morhua) within the Gulf of Maine

BMC Genomics, 2017
Background Atlantic cod (Gadus morhua), is known to vary genetically across the North Atlantic, Greenland, and Newfoundland. This genetic variation occurs both spatially and temporally through decades of heavy fishing, and is concentrated in three ...
Bryan T. Barney, Christiane Munkholm, David R. Walt, Stephen R. Palumbi   +3 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Genetic analysis of human absence epilepsy [PDF]

, 2010
Idiopathic Mendelian epilepsies have been typically identified as channelopathies. Evidence suggests that mutations in genes encoding GABAA receptors, GABAB receptors or voltage-dependent calcium channels (VDCCs) may underlie childhood absence epilepsy ...
Robinson, R.A.
core  

Candidate genes colocalized to linkage regions in inflammatory bowel disease [PDF]

, 2002
Background and Aims: The genes encoding for tumor necrosis factor-alpha (TNF-alpha), epidermal growth factor receptor (EGFR) and the vitamin D receptor (VDR) are colocalized to inflammatory bowel disease-associated linkage regions on chromosomes 6, 7 and
Folwaczny, Christian, Radimayr, M., Heinzlmann, M., Borchers, R., Martin, K.   +4 more
core   +1 more source

The Detection of Linkage in Human Genetics

Journal of the Royal Statistical Society Series B: Statistical Methodology, 1953
Summary There are three methods used in practice to detect human linkage. These are: (i)The sib-pair method of Penrose, applicable to pairs of brothers and sisters, when the parents’ genotypes are unknown or disregarded.(ii)The method of efficient scores (u-functions), due to Fisher and Finney, applicable to families consisting of 2 or ...
openaire   +2 more sources