Results 81 to 90 of about 342,848 (311)

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Models and partition of variance for quantitative trait loci with epistasis and linkage disequilibrium

BMC Genetics, 2006
Background A genetic model about quantitative trait loci (QTL) provides a basis to interpret the genetic basis of quantitative traits in a study population, such as additive, dominance and epistatic effects of QTL and the partition of genetic variance ...
Wang Tao, Zeng Zhao-Bang
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Skewed RAPD markers in linkage maps of Citrus

Genetics and Molecular Biology, 2004
The objective of this work was to analyze the effects of RAPD markers with skewed segregation on genetic linkage maps. Segregation data for 123 Citrus sinensis (L.) Osbeck cv. Pêra markers and 53 C. reticulata Blanco cv.
Roberto Pedroso de Oliveira, Carlos Ivan Aguilar-Vildoso, Mariângela Cristofani, Marcos Antônio Machado   +3 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

A population genetics model of marker-assisted selection [PDF]

, 1997
A deterministic two-loci model was developed to predict genetic response to marker-assisted selection (MAS) in one generation and in multiple generations.
Luo, Z. W., Woolliams, J. A., Luo, Z.W., Woolliams, John, Thompson, R.   +4 more
core  

The reference genetic linkage map for the multinational Brassica rapa genome sequencing project [PDF]

, 2007
We describe the construction of a reference genetic linkage map for the Brassica A genome, which will form the backbone for anchoring sequence contigs for the Multinational Brassica rapa Genome Sequencing Project.
Teakle, Graham R., Allender, Charlotte J., Beynon, E., Plaha, Prikshit, Lim, Yong Pyo, Bang, J. W., Kim, Jeong Hee, Koo, Dal Hoe, Koo, D. H., Allender, C. J., Plaha, P., Kim, J. H., Beynon, Elena, King, Graham J,, King, G. J., King, Graham J., Ham, T. H., Han, Tae Ho, Barker, Guy C., Bang, Jae Wook, Choi, Su Ryan, Choi, S. R., Teakle, G. R., Lydiate, D. J., Soengas, Pilar, Lydiate, Derek J., Edwards, David, Plahal, Prikshit, Lim, Y. P., Piao, Zhong Yun, Hand, Paul, Choi, Su Ryun, Soengas, P., Piao, Z. Y., Barker, G. C., Hand, P., Edwards, D., Park, Beom-Seok, Park, B-S., Batley, Jacqueline, Batley, J.   +40 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Accuracy of Predicting the Genetic Risk of Disease Using a Genome-Wide Approach [PDF]

, 2008
Background: The prediction of the genetic disease risk of an individual is a powerful public health tool. While predicting risk has been successful in diseases which follow simple Mendelian inheritance, it has proven challenging in complex diseases for ...
Daetwyler, Hans D., Daetwyler Hans D., Villanueva, Beatriz, Daetwyler, HD, Woolliams, John A., Hans D Daetwyler, John A Woolliams, Villanueva Beatriz, Daetwyler, H.D., Woolliams John A., Woolliams, JA, Villanueva, B., Beatriz Villanueva, Villanueva, B, Woolliams, J.A.   +14 more
core   +1 more source

Assortative Mating and Linkage Disequilibrium

G3: Genes, Genomes, Genetics, 2017
Assortative mating has been suggested to result in an increase in heritability and additive genetic variance through an increase in linkage disequilibrium.
Philip W. Hedrick
doaj   +1 more source