Results 161 to 170 of about 571,568 (315)

A genetic map of the chromatin regulators to drug response in cancer cells. [PDF]

J Transl Med, 2022
Chen B, Li P, Liu M, Liu K, Zou M, Geng Y, Zhuang S, Xu H, Wang L, Chen T, Li Y, Zhao Z, Qi L, Gu Y.   +13 more
europepmc   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Construction of a High-Density Paulownia Genetic Map and QTL Mapping of Important Phenotypic Traits Based on Genome Assembly and Whole-Genome Resequencing. [PDF]

Int J Mol Sci, 2023
Feng Y, Yang C, Zhang J, Qiao J, Wang B, Zhao Y.   +5 more
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Molecular characterisation of QTLs controlling fatness in pigs

, 2002
This thesis deals with the identification of genes controlling intramuscular fat and backfat thickness. Markers linked to quantitative trait loci (QTL) for these traits in the cross between Meishan x Large White breeds will lead to the identification of ...
Rattink, A.P.
core  

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Development of a high-throughput microsatellite typing approach for forensic and population genetic analysis of wild and domestic African Bovini

, 2008
Conservation management and forensic traceability of African buffalo and cattle rely on the timely provision of unbiased and accurate genetic information.
van Helden, P., Plessis, S., du, van Hooft, W.F., du Plessis, S., Kryger, P., Greyling, B.J., Hooft, W.F., van, Helden, P., van, Getz, W.M., Bastos, A.D.S.   +9 more
core  

Construction of a high-density genetic map and localization of grazing-tolerant QTLs in Medicago falcata L. [PDF]

Front Plant Sci, 2022
Zhou X, Li X, Zhang X, Yin D, Wang J, Zhao Y.   +5 more
europepmc   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Integration of the chicken genetic map with BAC contig-based physical maps using overgo hybridization

, 2003
Research is underway to align the chicken genetic linkage map, defined primarily by segregation of DNA-based markers, with the BAC contig physical maps developed recently (Zhang et al., Texas A&M; Sekhon and McPherson, Washington U.).
Dodgson, Jerry B, Price, J A, Romanov, Michael N   +2 more
core