Results 151 to 160 of about 3,863,878 (307)

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Novel Therapeutic Targets and Approaches, Genetic Markers and Signaling Pathways in Neoplasms-An Overview. [PDF]

Cells
Chudakova D.
europepmc   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Molecular Characterisation of the Romanian African Swine Fever Virus p72 and B602L Genetic Markers. [PDF]

Vet Sci
Gurău MR, Ștefan G, Gligor A, Beșleagă SL, Bărbuceanu F, Bărăităreanu S, Negru E, Hristescu DV, Vuță VB, Muțiu M, Donescu DN, Iancu I, Herman V, Costinar L, Pascu C, Daneș D.   +15 more
europepmc   +1 more source

Genetic diversity in chicken populations based on microsatellite markers

, 1999
The genomes of jungle and domestic fowl populations maintained in Ukraine and Germany were screened using microsatellites as molecular markers. Genetic variation within and between strains of different origin and performance potential was estimated and ...
Weigend, Steffen, Romanov, Michael N
core  

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Identification of genetic markers of quinine partial resistance in Plasmodium falciparum. [PDF]

Nat Microbiol
Kanai M, Mok S, Yeo T, Shears MJ, Jeon JH, Narwal SK, Ross LS, Wiradiputri K, Haile MT, Tripathi AK, Mlambo G, Kim J, Gil-Iturbe E, Park H, Ndiaye T, Okombo J, Ward KE, Rozenberg FD, Fairhurst KJ, Gavula SM, Bloxham TS, Bridgford JL, Sheth T, Llinás M, Lee MCS, Small-Saunders JL, Mancia F, Quick M, Uhlemann AC, Sinnis P, Fidock DA.   +30 more
europepmc   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Contribution of genetic markers to cerebral venous thrombosis risk among Tunisian patients: A case-control study. [PDF]

eNeurologicalSci
Moalla K, Smaoui E, Sakka S, Megdiche F, Bouattour N, Belhassen I, Smaoui R, Kallel C, Damak M.   +8 more
europepmc   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source