Results 201 to 210 of about 18,441,004 (311)

Uncovering Developmental Origins of Aortic Valve Disease: A Clinically Relevant Genetic Model of Aortic Stenosis. [PDF]

JACC Basic Transl Sci
Srivastava D.
europepmc   +1 more source

A combined clinical and genetic model for predicting risk of ovarian cancer. [PDF]

Eur J Cancer Prev, 2023
Dite GS, Spaeth E, Murphy NM, Allman R.
europepmc   +1 more source

Unlocking the potential of cell‐permeable nanobodies for intracellular applications

FEBS Letters, EarlyView.
This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés, Luise Franz, Christian P.R. Hackenberger   +2 more
wiley   +1 more source

Genetic Epidemiological Analysis of the Keratoconus Genetic Model in the Chinese Keratoconus Cohort Study. [PDF]

Invest Ophthalmol Vis Sci
Yin S, Xu L, Yang K, Fan Q, Gu Y, Yin C, Zang Y, Wang Y, Yuan Y, Chang A, Li C, Pang C, Sahebjada S, Hao Y, Ren S.   +14 more
europepmc   +1 more source

A genetic model for in vivo proximity labelling of the mammalian secretome. [PDF]

Open Biol, 2022
Yang R, Meyer AS, Droujinine IA, Udeshi ND, Hu Y, Guo J, McMahon JA, Carey DK, Xu C, Fang Q, Sha J, Qin S, Rocco D, Wohlschlegel J, Ting AY, Carr SA, Perrimon N, McMahon AP.   +17 more
europepmc   +1 more source

Comparing the paths of Hedgehog release in artificial and natural settings

FEBS Letters, EarlyView.
Hh morphogens require solubilization factors to overcome their tight association with the plasma membrane and signal to distant cells, but the precise functions of these factors are controversial. Here, we use published in vivo observations as the most relevant evidence to test their suggested functions and discuss contradictions and gaps between in ...
Janna Puschmann, Kay Grobe
wiley   +1 more source

From Digenic to Monogenic Sex Determination in Insects: A Genetic Model Based on Imprinting and X Chromosome Elimination. [PDF]

Genes (Basel)
Sánchez L.
europepmc   +1 more source

How structural disorder and polyelectrolyte properties of prothymosin α enable its large interactome

FEBS Letters, EarlyView.
In this review, complexes of the fully disordered and highly negatively charged prothymosin α are collected, described, and discussed. Linked to its poly‐electrostatic character, prothymosin α engages a large interactome through multiple different binding modes ranging from fully disordered complexes to short linear motif (SLiM)‐driven interactions ...
Ketty C. Tamburrini, Freia S. Buus, Benjamin Schuler, Birthe B. Kragelund   +3 more
wiley   +1 more source

Improvement in genetic evaluation of quantitative traits in sheep by enriching genetic model with dominance effects. [PDF]

Sci Rep
Ghafouri-Kesbi F, Mokhtari M, Gholizadeh M.   +2 more
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source