Results 211 to 220 of about 18,441,004 (311)

Erratum: Pertinence of glioma and single nucleotide polymorphism of TERT, CCDC26, CDKN2A/B, and RTEL1 genes in glioma: a meta-analysis

Frontiers in Oncology
Frontiers Production Office
doaj   +1 more source

Retinoic Acid Inhibition Alters Intestinal Composition in Zebrafish: A Non-genetic Model to Study Hirschsprung Disease? [PDF]

Neurogastroenterol Motil
Kakiailatu NJM, Zhang W, Kuil LE, Bindels E, Zink JTM, Vermeulen M, de Pater E, Melotte V, Alves MM.   +8 more
europepmc   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

In Vivo Models of Cardiovascular Disease: <i>Drosophila melanogaster</i> as a Genetic Model of Congenital Heart Disease. [PDF]

Biomedicines
Stougiannou TM, Koutini M, Mitropoulos F, Karangelis D.   +3 more
europepmc   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

<i>Drosophila</i> as a Genetic Model System to Study Organismal Energy Metabolism. [PDF]

Biomolecules
Diaz AV, Tekin I, Reis T.
europepmc   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Genetic model for fluorite mineralization at the AGS deposit, St. Lawrence, Newfoundland, Canada: REY patterns, fluid inclusion analysis, Nd-Sm dating, and C, O and S isotopes. [PDF]

Miner Depos
Magyarosi Z, Conliffe J, Kontak DJ, Creaser R.   +3 more
europepmc   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Elevated synaptic PKA activity and abnormal striatal dopamine signaling in Akap11 mutant mice, a genetic model of schizophrenia and bipolar disorder. [PDF]

Nat Commun
Song BJ, Ge Y, Nicolella A, Kwon MJ, Lodder B, Bonanno K, Valle-Tojeiro A, Hartley ND, Perzel Mandell K, Adeleye J, Misri D, Geng C, Natarajan S, Picard I, Shepard N, Hall A, Tian J, Aryal S, Farsi Z, Liu XM, Morshed N, Nadaf NM, Pribiag H, Simmons SK, Mani DR, Stevens B, Kunwar PS, Fu Z, Macosko EZ, Levin JZ, Sabatini BL, Carr SA, Dejanovic B, Keshishian H, Granger AJ, Sheng M.   +35 more
europepmc   +1 more source