Results 1 to 10 of about 610,488 (258)

Genetic Modification of Brain Organoids [PDF]

Frontiers in Cellular Neuroscience, 2019
Brain organoids have become increasingly used systems allowing 3D-modeling of human brain development, evolution, and disease. To be able to make full use of these modeling systems, researchers have developed a growing toolkit of genetic modification ...
Jan Fischer, Michael Heide, Wieland B. Huttner   +2 more
doaj   +6 more sources

Heart immunoengineering by lentiviral vector-mediated genetic modification during normothermic ex vivo perfusion [PDF]

Frontiers in Immunology
Heart transplantation is associated with major hurdles, including the limited number of available organs for transplantation, the risk of rejection due to genetic discrepancies, and the burden of immunosuppression.
Katharina Schmalkuche, Katharina Schmalkuche, Tamina Rother, Jonathan M. Burgmann, Henrike Voß, Klaus Höffler, Günes Dogan, Arjang Ruhparwar, Jan D. Schmitto, Rainer Blasczyk, Rainer Blasczyk, Constanca Figueiredo, Constanca Figueiredo   +12 more
doaj   +2 more sources

Probiotics and the Potential of Genetic Modification as a Possible Treatment for Food Allergy [PDF]

Nutrients, 2023
Zheng Ding, Jiazeng Sun
exaly   +2 more sources

Key Cannabis Salt-Responsive Genes and Pathways Revealed by Comparative Transcriptome and Physiological Analyses of Contrasting Varieties

Agronomy, 2021
For the dissection and identification of the molecular response mechanisms to salt stress in cannabis, an experiment was conducted surveying the diversity of physiological characteristics.
Jiangjiang Zhang, Cuiping Zhang, Siqi Huang, Li Chang, Jianjun Li, Huijuan Tang, Susmita Dey, Ashok Biswas, Dengxiang Du, Defang Li, Lining Zhao   +10 more
doaj   +1 more source

Socratic dialogue on responsible innovation – a methodological experiment in empirical ethics

Etikk i Praksis: Nordic Journal of Applied Ethics, 2022
This article presents an experiment in using Socratic dialogue as a methodological approach to Responsible Research and Innovation (RRI) in an interdisciplinary life sciences research project.
Bjørn K. Myskja, Alexander Myklebust
doaj   +1 more source

Advanced progress in the genetic modification of the oncolytic HSV-1 virus [PDF]

Frontiers in Oncology
Zhou M, Shen Z.
exaly   +2 more sources

Authorizing GM Crop Varieties: Policy Implications for Seed Systems in Sub-Saharan Africa

Agronomy, 2021
Considering an expanding research and development pipeline of and growing practical experiences with genetically modified (GM) crops, governments in Sub-Sahara Africa have in recent years authorized various GM crop events for general, unconfined ...
John Komen, David K. Wafula
doaj   +1 more source

Genetic Diversity and Population Structure of Cannabis Based on the Genome-Wide Development of Simple Sequence Repeat Markers

Frontiers in Genetics, 2020
Cannabis has been used as a source of nutrition, medicine, and fiber. However, lack of genomic simple sequence repeat (SSR) markers had limited the genetic research on Cannabis species.
Jiangjiang Zhang, Jiangtao Yan, Siqi Huang, Siqi Huang, Gen Pan, Gen Pan, Li Chang, Li Chang, Jianjun Li, Jianjun Li, Chao Zhang, Huijuan Tang, Huijuan Tang, Anguo Chen, Anguo Chen, Dingxiang Peng, Ashok Biswas, Cuiping Zhang, Cuiping Zhang, Lining Zhao, Lining Zhao, Defang Li, Defang Li   +22 more
doaj   +1 more source

Production of large, defined genome modifications in rats by targeting rat embryonic stem cells

Stem Cell Reports, 2023
Summary: Rats were more frequently used than mice to model human disease before mouse embryonic stem cells (mESCs) revolutionized genetic engineering in mice.
Jeffrey Lee, Jingjing Wang, Roxanne Ally, Sean Trzaska, Joseph Hickey, Alejo Mujica, Lawrence Miloscio, Jason Mastaitis, Brian Morse, Janell Smith, Amanda Atanasio, Eric Chiao, Henry Chen, Adrianna Latuszek, Ying Hu, David Valenzuela, Carmelo Romano, Brian Zambrowicz, Wojtek Auerbach   +18 more
doaj   +1 more source

Human B Cell Responses to Dominant and Subdominant Antigens Induced by a Meningococcal Outer Membrane Vesicle Vaccine in a Phase I Trial

mSphere, 2022
Neisseria meningitidis outer membrane vesicle (OMV) vaccines are safe and provide strain-specific protection against invasive meningococcal disease (IMD) primarily by inducing serum bactericidal antibodies against the outer membrane proteins (OMP).
Christine S. Rollier, Christina Dold, Leanne Marsay, Aline Linder, Christopher A. Green, Manish Sadarangani, Gunnstein Norheim, Jeremy P. Derrick, Ian M. Feavers, Martin C. J. Maiden, Andrew J. Pollard   +10 more
doaj   +1 more source