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Genetic Modification of T Cells
The Cancer Journal, 2014Gene transfer technology has advanced rapidly from simple physical-chemical laboratory methods in the 1970s and 1980s to the sophisticated viral and nonviral methods currently in clinical practice. Herein, we review 4 gene transfer methodologies applied in human gene therapy clinical trials transferring chimeric antigen receptors into T cells for the ...
Richard A, Morgan, Sunitha, Kakarla
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Ethics of Genetic Modifications of behavior
Accountability in Research, 2004Genetic interventions to ameliorate genetically-based diseases can serve the private and public good.
Adil E, Shamoo, John, Cole
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Naturalness and the genetic modification of animals
Trends in Biotechnology, 2003In the past few years it has been recognised that so-called intrinsic concerns about genetic modification (GM) of plants and animals, for food in particular, have an important role in the public perception of GM. One of these concerns is the view that GM is 'unnatural'.
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2000
Abstract To explore the role of a gene, we need to analyse its regulation and expression during and after development, the function of its product, and interactions with other proteins. In most cases, it is necessary to be able to transfer the gene, or its manipulated form, into cells.
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Abstract To explore the role of a gene, we need to analyse its regulation and expression during and after development, the function of its product, and interactions with other proteins. In most cases, it is necessary to be able to transfer the gene, or its manipulated form, into cells.
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Genetic modification of cells for transplantation
Advanced Drug Delivery Reviews, 2008Progress in gene therapy has produced promising results that translate experimental research into clinical treatment. Gene modification has been extensively employed in cell transplantation. The main barrier is an effective gene delivery system. Several viral vectors were utilized in end-stage differentiated cells.
Yi, Lai +4 more
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Genetic modification of food allergens
Annals of Allergy, Asthma & Immunology, 2004To review allergen risk evaluation for genetically modified foods and our ability to predict protein allergenicity, methods that are being used to develop foods with reduced allergenic activity, and clinical aspects relative to assessing potentially allergic patients.Information was identified using the MEDLINE database for governmental, international,
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Protoplasts in genetic modifications of plants
1981Rapid advances have been made in recent years in plant protoplast technology and research applications. Isolated protoplasts have been used successfully in virology and cell genetics. Protoplast fusion is feasible and a variety of hybrid cells of different plant genera have been produced.
Oluf L. Gamborg, Paul J. Bottino
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Advancement of Biotechnology by Genetic Modifications
2018One of the greatest sources of metabolic and enzymatic diversity are microorganisms. In recent years, emerging recombinant DNA and genomic techniques have facilitated the development of new efficient expression systems, modification of biosynthetic pathways leading to new metabolites by metabolic engineering, and enhancement of catalytic properties of ...
Arnold L, Demain, Sergio, Sánchez
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Genetic modification of proteins in food
Critical Reviews in Food Science and Nutrition, 1996Plant breeders have been extremely successful in improving the quality and yield of the major crops, while maintaining the safety of the food supply. This success has been achieved with very little understanding of the biochemical mechanisms that determine the selected traits.
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Sperm-Mediated Genetic Modifications
2019The ability to introduce controlled modifications of the genome of animals represents an important tool for biomedical and veterinary research. Among transgenic techniques, we describe here the sperm-mediated gene transfer method that is based on the spontaneous ability of sperm cells to bind and internalize exogenous DNA and to carry it to the oocyte ...
Lavitrano, M +3 more
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