Results 101 to 110 of about 43,517 (303)

Phosphoinositides and inositol phosphates as molecular glues

open access: yesFEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry   +9 more
wiley   +1 more source

Predictive Models Using Fitness Distributions of Genetic Operators [PDF]

open access: yes, 1995
An important goal of the theory of genetic algorithms is to build predictive models of how well genetic algorithms are expected to perform, given a representation, a fitness landscape, and a set of genetic operators. This paper attempts to provide pieces
John J. Grefenstette
core   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

open access: yesFEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee   +7 more
wiley   +1 more source

ECONOMIC POWER DISPATCH USING THE COMBINATION OF TWO GENETIC ALGORITHMS

open access: yesElectrica, 2006
Lately, one notices an increase in the applications of the genetic algorithms (GA) through several fields, and one noted that all the utilisateurs(exploiteurs) these algorithms wonder on the choice of the values of the genetic operators in order to ...
Mimoun YOUNES, Mostafa RAHLI
doaj   +2 more sources

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

open access: yesFEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Static task allocation algorithm for multi-heterogeneous UAVs based on improved genetic operators [PDF]

open access: yesZhihui kongzhi yu fangzhen
To address the issues of insufficient global optimality and robustness in traditional mission planning for unmanned aerial vehicles (UAVs) in urban disaster relief scenarios, this paper proposes a multi-heterogeneous UAV static task allocation algorithm ...
WANG Chengfei
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

open access: yesFEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar   +4 more
wiley   +1 more source

A Study of the Performance Effect of Genetic Operators [PDF]

open access: yes, 2009
Performance of genetic algorithms (GAs) is mainly determined by several factors. Not only the genetic operators affect the performance of a GA with varying degrees, but also the parameter settings for genetic operators interact in a complicated manner ...
Pi-Sheng Deng
core   +1 more source

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

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