Results 91 to 100 of about 43,517 (303)

Diversity and complexity in neural organoids

open access: yesFEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

An Evolutionary Approach to the Soft Error Mitigation Technique for Cell-Based Design

open access: yesAdvances in Electrical and Computer Engineering, 2015
In this paper, we present a soft error mitigation algorithm that searches for the proper gate sizes within constrained gate-level designs. The individual gate sizing has an impact on the former optimization results and degrades the quality of the ...
PARK, J. K., KIM, J. T.
doaj   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

open access: yesFEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Application of Topological Operators over Data from InterCriteria Analysis [PDF]

open access: yes, 2017
In this paper, two topological operators T and U over intuitionistic fuzzy sets are considered and applied. As a case study a parameter identification problem of E. coli fed-batch cultivation process model using genetic algorithms is investigated.
Vassilev, P., Roeva, O., Chountas, P.
core   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

open access: yesFEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil   +4 more
wiley   +1 more source

Adaption of Operator Probabilities in Genetic Programming [PDF]

open access: yes, 2001
In this work we tried to reduce the number of free parameters within Genetic Programming without reducing the quality of the results. We developed three new methods to adapt the probabilities, different genetic operators are applied with. Using two problems from the areas of symbolic regression and classification we showed that the results in these ...
Jens Niehaus, Wolfgang Banzhaf
openaire   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

open access: yesFEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

open access: yesFEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson   +6 more
wiley   +1 more source

A Genetic Algorithm Based on Combination Operators [PDF]

open access: yes, 2011
Dual operator and inverse operator are defined as two new genetic operators respectively in this paper. Then a genetic algorithm based on inverse and dual combination operator was designed to overcome the defect of genetic algorithm in local searching ...
Zhou, Xiangguang, Shuai, Xunbo
core   +1 more source

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