Results 81 to 90 of about 947,581 (290)

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Numerical investigation of Differential Biological-Models via GA-Kansa Method Inclusive Genetic Strategy

, 2017
In this paper, we use Kansa method for solving the system of differential equations in the area of biology. One of the challenges in Kansa method is picking out an optimum value for Shape parameter in Radial Basis Function to achieve the best result of ...
Fallah, Mohammad Kazem, Hemami, Mohammad, Parand, Kourosh   +2 more
core  

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Neutral Aggregation in Finite Length Genotype space

, 2016
The advent of modern genome sequencing techniques allows for a more stringent test of the neutrality hypothesis of Darwinian evolution, where all individuals have the same fitness.
Houchmandzadeh, Bahram
core   +3 more sources

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Genetic variability of the length of postpartum anoestrus in Charolais cows and its relationship with age at puberty

Genetics Selection Evolution, 2000
Fertility records (n = 1 802) were collected from 615 Charolais primiparous and multiparous cows managed in an experimental herd over an 11-year period.
Ménissier François, Krauss Daniel, Renand Gilles, Mialon Marie-Madeleine   +3 more
doaj   +1 more source

Genetic Parameters for Fertility of Dairy Bulls

Journal of Dairy Science, 1988
Genetic parameters for male fertility and fertility ratings of AI bulls were obtained by analyzing 298,013 service records of cows with successive calving records. Cows were mated to 746 service bulls, which were progeny of 126 sires. The model for variance component estimation accounted for fixed effects of herd-year-seasons, sire of the service bull,
K, Nadarajah, E B, Burnside, L R, Schaeffer   +2 more
openaire   +2 more sources

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Genomic Region Containing Toll-Like Receptor Genes Has a Major Impact on Total IgM Antibodies Including KLH-Binding IgM Natural Antibodies in Chickens

Frontiers in Immunology, 2018
Natural antibodies (NAb) are antigen binding antibodies present in individuals without a previous exposure to this antigen. Keyhole limpet hemocyanin (KLH)-binding NAb levels were previously associated with survival in chickens.
Tom V. L. Berghof, Tom V. L. Berghof, Marleen H. P. W. Visker, Joop A. J. Arts, Henk K. Parmentier, Jan J. van der Poel, Addie L. J. Vereijken, Henk Bovenhuis   +7 more
doaj   +1 more source

Momentum state engineering and control in Bose-Einstein condensates

, 2001
We demonstrate theoretically the use of genetic learning algorithms to coherently control the dynamics of a Bose-Einstein condensate. We consider specifically the situation of a condensate in an optical lattice formed by two counterpropagating laser ...
B.J. Pearson, B.P. Anderson, B.P. Anderson, C. Cohen-Tannoudji, C. Raman, C.F. Bharucha, C.K. Law, D. A. Coley, D. Choi, D. Jaksch, E. Peik, E. Peik, E.W. Hagley, F.S. Cataliotti, J. Denschlag, J. Stenger, J.E. Simsarian, K.S. Johnson, L. Deng, M. Kozuma, M. Olshanii, M.B. Dahan, M.G. Moore, Marcus Cramer, O. Morsch, O. Zobay, P. Meystre, P.B. Blakie, Pierre Meystre, Q. Niu, R. Onofrio, R.S. Judson, S. Burger, S. Burger, S. Inouye, S. Inouye, S. Pötting, Sierk Pötting, T.C. Weinacht, U. Drodofsky, V. Milner, Ł. Dobrek   +41 more
core   +1 more source