Results 101 to 110 of about 10,561,542 (295)

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Morphoagronomic characterization of sweet potato accessions from the germplasm bank of Embrapa hortaliças

Bioscience Journal, 2019
Studies on the determination of genetic divergence among genotypes are important tools in breeding programs, contributing to the identification of parents with considerable productive potential.
Rosa maria de Deus de Sousa, José Ricardo Peixoto, Geovani Bernardo Amaro, Michelle Sousa Vilela, Paula Andrea Osorio Carmona   +4 more
doaj  

Desempenho agronômico de linhas endogâmicas ecombinadas de Capsicum annuum L. em sistema orgânico sob cultivo protegido Agronomic performance of recombinant inbred of Capsicum annuum L. lines cultivated under organic system and greenhouse conditions

Ciência e Agrotecnologia, 2010
O manejo de plantas em cultivo protegido e a busca de produtos orgânicos pelos consumidores têm sido um desafio para produtores e pesquisadores de hortaliças.
Sarah Ola Moreira, Rosana Rodrigues, Maria Luíza de Araújo, Elaine Manelli Riva-Souza, Rebeca Lourenço de Oliveira   +4 more
doaj   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Herdabilidade da habilidade de permanência no rebanho em fêmeas de bovinos da raça Canchim Heritability for stayability in Canchim beef cattle breed

Pesquisa Agropecuária Brasileira, 2007
O objetivo deste trabalho foi avaliar a possibilidade de a característica habilidade de permanência no rebanho de matrizes ser utilizada como critério de seleção na raça Canchim. A habilidade de permanência no rebanho foi definida como a probabilidade de
Leonardo Martin Nieto, Luiz Otavio Campos da Silva, Cintia Righetti Marcondes, Antônio do Nascimento Rosa, Elias Nunes Martins, Roberto Augusto de Almeida Torres Júnior   +5 more
doaj   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Estimates of heritability and genetic correlations for meat quality traits in broilers

Scientia Agricola, 2011
Broiler meat quality is one of the primary factors considered by the poultry industry. This study was conducted to estimate heritability and genetic correlation coefficients for meat quality traits in a single male broiler line.
Leila de Genova Gaya, Gerson Barreto Mourão, José Bento Sterman Ferraz, Elisângela Chicaroni de Mattos, Andrezza Marcovig Moreira Alves da Costa, Tércio Michelan Filho, Alessandra Fernandes Rosa, Andrezza Maria Felício, Joanir Pereira Eler   +8 more
doaj   +1 more source

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

Genetic analysis of yield, yield-components and related phenological traits of maize (Zea mays L.) to breed under moisture stress conditions [PDF]

Desert, 2018
Improved drought-tolerant maize hybrids would significantly reduce water consumption and increase yield in arid environments. Our knowledge about genetic parameters is very essential before starting a successful breeding program. The present research was
S.S. Moosavi, F. Ghanbari, M.R. Abdollahi, A.R. Kiani   +3 more
doaj  

Genetic parameters for type score traits and milk production in Brazilian Jersey herds [PDF]

, 2018
Mayara Andressa Sabedot, Gabriela Romano, Victor Breno Pedrosa, Luís Fernando Batista Pinto   +3 more
openalex   +1 more source