Results 121 to 130 of about 12,859,837 (351)
Variability in genetic parameters among small populations
Genetical Research, 1977 SUMMARYFor a model in which quantitative traits are assumed to be determined solely by additive genes at many loci, formulae are developed for the variance among replicated small populations of sizeN, maintained without selection, of the additive genetic variance, heritability, genetic correlations and similar parameters. The base population is assumed
P J, Avery, W G, Hill
openaire +2 more sources
On the Implementation and Use of a Genetic Algorithm with Genetic Acquisitions [PDF]
A genetic algorithm is convergent when genetic mutations occur on the objective function gradient direction. These genetic mutations are called genetic acquisitions (Mateescu, 2005).
Mateescu, George Daniel
core
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Evolutionary associations between sand seatrout (Cynoscion arenarius) and silver seatrout (C. nothus) inferred from morphological characters, mitochondrial DNA, and microsatellite markers [PDF]
, 2009 The evolutionary associations between closely related fish species, both contemporary and historical, are frequently assessed by using molecular markers, such as microsatellites.
Anderson, Joel D. +3 more
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Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Maternal effects on the genetic evaluation of Tabapuã beef cattle
Genetics and Molecular Biology, 2004 The aim of this investigation was to study the influence of maternal effects on the genetic evaluation of sire production in Tabapuã beef cattle. Single and multiple trait analyses were done with adjusted animal weights at 120, 240 and 420 days of age ...
José Elivalto Guimarães Campêlo +6 more
doaj +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Animal, 2009 A multi-trait animal model was used to estimate genetic parameters among lactation somatic cell score (SCS) and udder-type traits in South African Jersey cattle, through restricted maximum likelihood (REML) procedures.
B. Dube, K. Dzama, C.B. Banga, D. Norris
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Genetic algorithms in seasonal demand forecasting [PDF]
The method of forecasting seasonal demand applying genetic algorithm is presented. Specific form of used demand function is shown in the first section of the article.
Chodak, Grzegorz, Kwaśnicki, Witold
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, 2008 Molecular codes translate information written in one type of molecules into another molecular language. We introduce a simple model that treats molecular codes as noisy information channels.
Tlusty, Tsvi
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