Results 41 to 50 of about 666,141 (292)

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Effect of MTHFR (rs1801133) and FTO (rs9939609) genetic polymorphisms and obesity in T2DM: a study among Bengalee Hindu caste population of West Bengal, India

Annals of Human Biology, 2021
Type 2 diabetes mellitus (T2DM) susceptibility has increased due to the independent risks of genetic polymorphism and obesity as well as combinations of these. Despite recent advancements in T2DM management and diagnosis, the challenges of susceptibility
Pranabesh Sarkar, Diptendu Chatterjee, Arup Ratan Bandyopadhyay   +2 more
doaj   +1 more source

Development of SSR markers from Citrus clementina (Rutaceae) BAC end sequences and interspecific transferability In Citrus (P148) [PDF]

, 2011
Microsatellite primers were developed from bacterial artificial chromosome (BAC) end sequences (BES) of Citrus clementina and their transferability and polymorphism tested in the genus Citrus for future anchorage of physical and genetic maps and ...
Navarro, Luis, Ollitrault, Frédérique, Ollitrault, Patrick, Pina, José Antonio, Talon, Manuel, Terol, Javier F.   +5 more
core  

Genetic Polymorphism in Evolving Population

, 1998
We present a model for evolving population which maintains genetic polymorphism. By introducing random mutation in the model population at a constant rate, we observe that the population does not become extinct but survives, keeping diversity in the gene
D. Alves, D. J. Futuyma, D. Kim, F. Manzo, H. Y. Lee, I. Mróz, J. L. Hamrick, J. V. Neel, L. Snyder, M. Eigen, M. Eigen, M. Eigen, M. Serva, M. Y. Choi, P. G. Higgs, R. K. Selander, T. Dobzhansky, T. Mukai   +17 more
core   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Evaluation of the Importance of Genetic Polymorphisms in Genes Expressing Cancer-Metabolizing Enzymes (Cyp1a1 and Gstm1) in Oral Submucous Fibrosis

Journal of Pharmacy and Bioallied Sciences
Background: Genetic polymorphisms are common and contribute significantly to human illnesses. Aim: This study was carried out to evaluate the importance of genetic variations in the genes expressing cancer-metabolizing enzymes (CYP1A1 and GSTM1) in ...
Devina Pradhan, Tarang Mehta, Arpita Srivastava, Deepak Patel, Kailash Chandra Dash, Vidya Hittalamani, Ramanpal Singh Makkad   +6 more
doaj   +1 more source

Evaluation of genetic diversity in Alcea (Malvaceae) using SRAP markers

Botan‪ical Sciences, 2014
In this work, sequence-related amplified polymorphism (SRAP) marker was employed to assess the genetic diversity and genetic similarity relationships among14 species of Alcea collected from northwest of Iran. Seventeen SRAP primer combinations generated
Nasibeh Badrkhani, Fatemeh Rahmani, Mozhgan Larti   +2 more
doaj   +1 more source

Dominant gingers – Discovery and inheritance of a new shell polymorphism in the great pond snail Lymnaea stagnalis

Ecology and Evolution, 2023
Color polymorphism is a classic study system for evolutionary genetics. One of the most color‐polymorphic animal taxa is mollusks, but the investigation of the genetic basis of color determination is often hindered by their life history and the limited ...
Matthijs Ledder, Yumi Nakadera, Alexandra Staikou, Joris M. Koene   +3 more
doaj   +1 more source

Identification and Validation of EST-Derived Molecular Markers, TRAP and VNTRs, for Banana Research [PDF]

, 2011
The advent of high-throughput sequencing technology has generated abundant information on DNA sequences for the genomes of many plant species. Expressed Sequence Tags (ESTs), which are unique DNA sequences derived from a cDNA library and therefore ...
Ferreira, C.F., Garcia, S.A.L., Kema, G.H.J., Paiva, L.V., Souza, M.T., Talebi, R., Vroh, B.I.   +6 more
core   +2 more sources

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source