Results 51 to 60 of about 666,141 (292)
Population genomics: whole-genome analysis of polymorphism and divergence in Drosophila simulans. [PDF]
PLoS Biology, 2007 The population genetic perspective is that the processes shaping genomic variation can be revealed only through simultaneous investigation of sequence polymorphism and divergence within and between closely related species.
David J Begun +12 more
doaj +1 more source
Aggregation of Single Nucleotide Polymorphisms in a Human H5N1 Clade 2.2 Hemagglutinin [PDF]
, 2007 The evolution of H5N1 has attracted significant interest 1-4 due to linkages with avian 5,6 and human infections 7,8. The basic tenets of influenza genetics 9 attribute genetic drift to replication errors caused by a polymerase complex that lacks a ...
Abdelattar Arafa +17 more
core +2 more sources
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
Association of IRGM (rs1000113 C/T) Genetic Polymorphism with the Incidence of Acute Rejection in Iranian Liver Transplanted Patients [PDF]
Journal of Advanced Biomedical Sciences, 2019 Background & Objective: Autophagy has been shown to be involved in organ transplantation. IRGM (human immunity-related GTPase) has a crucial role in autophagy complex activation and ROS and microorganism elimination during graft rejection.
Zahra Malekpour, Farshid Kafilzadeh
doaj
BMC Cardiovascular Disorders, 2021 Background Essential hypertension is a complex disease determined by the interaction of genetic and environmental factors, eNOS is considered to be one of the susceptible genes for hypertension.
Jikang Shi +8 more
doaj +1 more source
The potential role of genetic markers in talent identification and athlete assessment in elite sport [PDF]
, 2018 In elite sporting codes, the identification and promotion of future athletes into specialized talent pathways is heavily reliant upon objective physical, technical, and tactical characteristics, in addition to subjective coach assessments.
Anderton, Ryan S +3 more
core +2 more sources
Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source
Association study of suicidal behavior and affective disorders with a genetic polymorphism in ABCG1, a positional candidate on chromosome 21q22.3 [PDF]
, 2000 The gene that codes for the ABC transporter ABCG1 is located in a chromosomal susceptibility region (21q22.3) for affective disorders. Genetic variations in ABCG1 have been associated with affective disorders in Japanese males.
Anghelescu, I. +9 more
core +1 more source
FEBS Open Bio, EarlyView.dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon +6 more
wiley +1 more source
Open Medicine, 2019 Folate metabolism plays quite a critical role in Parkinson’s disease (PD). Previous published research works have studied the link existing between the folate metabolism genetic polymorphisms and PD susceptibility; nevertheless, the results continue ...
Diao Hong-Mei +2 more
doaj +1 more source