Results 121 to 130 of about 319,093 (308)

Mechanostimulatory Cues Determine Intestinal Fibroblast Fate and Profibrotic Remodeling in a Physiodynamic Human Gut‐on‐a‐Chip

Advanced Science, EarlyView.
A healthy gut barrier shields underlying fibroblasts from luminal shear forces, illustrating that “good fences make good neighbors.” Barrier damage exposes fibroblasts to shear stress, inducing cell death and the emergence of stress‐adapted, profibrotic fibroblasts. Sustained shear exposure promotes the formation of stiff aggregates of mechanoadapative
Soyoun Min, Nam Than, Yong Cheol Shin, Elif G. Ertugral, Chandrasekhar R. Kothapalli, Olumuyiwa Awoniyi, Hyun Jung Kim   +6 more
wiley   +1 more source

Dissecting the Ecological Structure of Health and Disease in the Global Gut Microbiome

Advanced Science, EarlyView.
We introduce Wiredancer, a framework that identifies three continuous ecological factors of the gut microbiota. These factors exhibit distinct patterns across health and disease, jointly capturing disrupted ecological stability and offering a new perspective for precision diagnostics and therapeutic strategies.
Baoyuan Zhu, Shuhao Chen, Yunheng Diao, Wei Wang, Yuanyuan Huang, Liqin Liang, Xiaodan Lu, Rui Han, Minxin Guo, Zhaobo Li, Shuhong Wang, Hehua Li, Chenyu Liu, Jing Zhou, Dongsheng Xiong, Xiaobo Li, Yuping Ning, Xuetao Shi, Fengchun Wu, Kai Wu   +19 more
wiley   +1 more source

The Nordic ChiCaP Network: An interdisciplinary approach to childhood cancer predisposition

Rare
Testing for Childhood Cancer Predisposition (ChiCaP) syndromes is increasingly common in pediatric oncology as early identification can help adapt treatment and initiate surveillance.
Fulya Taylan, Joel Janhonen, Katja Ekholm, Svetlana Bajalica-Lagercrantz, Stefan Becker, Andreas Benneche, Patrick Cairns, Åsa Grauman, Maria Haanpää, Ole Haubjerg Nielsen, Hildegunn Høberg Vetti, Lauge Holm Sørensen, Bushra Ishaq, Kirsi Jahnukainen, Andreina Kero, Ida Katrine Knapstad, Laura S. Korhonen, Ekaterina Kuchinskaya, Kristina Lagerstedt-Robinson, Hanne C. Lie, Gustaf Ljungman, Carolina Maya-González, Saara Nolvi, Kristiina Nordfors, Thale Kristin Olsen, Sara Orrsjö, Anna Poluha, Kjeld Schmiegelow, Ulrik Kristoffer Stoltze, Sonja Strang-Karlsson, Alexander Sun Zhang, Bianca Tesi, Giorgio Tettamanti, Emma Tham, Alexandra Wachtmeister, Karin A.W. Wadt, Ayo Wahlberg, Teresia Wangensteen, Joakim Wille, Monica Cheng Munthe-Kaas, Ann Nordgren   +40 more
doaj   +1 more source

Self‐Assembling Hybrid Hydrogel Reprograms the Stromal Vascular Fraction to Treat Osteoarthritis

Advanced Science, EarlyView.
This study presents a bioinspired injectable hydrogel that enhances the therapeutic potential of stem cell‐rich stromal vascular fraction for treating osteoarthritis. By reprogramming cell behavior through epigenetic modulation, the hydrogel promotes cartilage regeneration and reduces joint damage in a rat model, offering a promising new approach for ...
Waifang Hou, Yongfeng Chen, Longyou Xiao, Wei Qi, Tianshu Du, Qiang Sun, Borui Xue, Qinghe Zhao, Pengfei Xie, Zi Ye, Fei Han, Lingli Guo, Yang Jiao, Ranran Zhang, Hong Jia, Xiao Huang, Jianwei Guo, Peng Wang, Huayi Wang, Yuanrui Wang, Wenjing Chen, Haining Wu, Liumin He, Dawei Zhang   +23 more
wiley   +1 more source

Dupuytren\u27s Disease [PDF]

, 2017
Dupuytren\u27s disease (DD) is a chronic condition in which fibrosis of tissue beneath the palm of the hand occurs. Causes and mechanisms of this disease\u27s development are still not entirely understood.
Pinckney, Leah C.
core   +1 more source

KCNJ2 is Required for NLRP3 Inflammasome Activation That Drives Allergic Airway Inflammation and Remodeling

Advanced Science, EarlyView.
This study aims to evaluate the impact of the potassium channel KCNJ2 on asthma development. KCNJ2 promotes NLRP3 inflammasome activation through both Ca2+ influx and K+ efflux in airway epithelial cells, which drives allergic airway inflammation and remodeling, suggesting a promising therapeutic target for asthma.
Yachao Cui, Shumei Wu, Yang Peng, Yiqi Liu, Li Che, Shiying Chen, Feng Zhang, Dajiang Qin, Shiyue Li, Pixin Ran, Wenguang Yin   +10 more
wiley   +1 more source

Age at Coronary Heart Disease Onset, Genetic Susceptibility, and Subsequent Risk of Stroke

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Coronary heart disease (CHD) has been established as a risk factor for stroke. The study aimed to assess how age at CHD onset influences stroke risk and interacts with genetic predisposition to stroke.
Yi Qi, Wen‐Hao Liu, Qing‐Yuan Gao, Jing‐Wei Gao, Zhi‐Teng Chen, Yong‐Xiang Ruan, Hao‐Peng Liu, Si You, Xu‐Hui Wu, Jing‐Feng Wang, Pin‐Ming Liu, Hai‐Feng Zhang, Yang‐Xin Chen   +12 more
doaj   +1 more source

Genetic predisposition to periodontal disease: A review

Genetika
Periodontal disease is a complex, multifactorial disease and the predisposition to its occurrence is genetically determined. A multitude of research projects on genotyping of patients and controls in search of putative genetic risk factors has been performed.
Ana Pejcic, Ivan Minic, Milena Kostic, Marija Bradic-Vasic, Dzemil Kurtagic   +4 more
openaire   +1 more source

Delivery of Pleckstrin‐Homology Domains Suppresses PI3K/Akt Signaling and Breast Cancer Metastasis

Advanced Science, EarlyView.
Current therapies curb tumor growth but not metastasis. Obscurin, a giant metastasis suppressor lost in breast cancer, restrains PI3K/Akt signaling but is impractical to restore. We deploy a mini‐obscurin, comprising the obscurin‐PH‐domain, which sequesters PI3K‐p85, potently suppressing invasion and metastasis.
Matthew Eason, Anindya Sen, Suhan Cho, Se Jong Lee, Keyata Thompson, Md Musavvir Mahmud, Poornima Dubey, Talia Guardia, Anthony Kim, Stuart Martin, Nathan Wright, Konstantinos Konstantopoulos, Aikaterini Kontrogianni‐Konstantopoulos   +12 more
wiley   +1 more source

Macrophage Extracellular Traps in Immunity and Cancer

Advanced Science, EarlyView.
As a macrophage‐mediated innate defense mechanism, the dysregulated release of METs drives chronic inflammation and influences tumor progression. Furthermore, METs exhibit a functional duality within the tumor microenvironment, capable of both promoting and suppressing tumor development.
Junyao Li, Eugenie Nepovimova, Adam Grundel, Lukas Peter, Qinghua Wu, Kamil Kuca   +5 more
wiley   +1 more source