Results 131 to 140 of about 2,712,849 (369)

A Comprehensive Analysis of HLA-A and HLA-DR Allele Frequencies and Haplotype Associations in a Korean Population of 790 Individuals

Korean Journal of Clinical Laboratory Science
The human leukocyte antigen (HLA) system, which is part of the major histocompatibility complex (MHC) plays a vital role in immune responses by differentiating between itself and foreign cells and antigens.
Hee-Kyung HAN, Mi Hyun KIM, Seong Su JEONG, Dong Kwon KIM, Youngtaek KIM, Joon Yeon HWANG, Seong-san KANG, Seung Min YANG, Seul LEE, Sujeong BAEK, Kwangmin NA, Chai Young LEE, Yu Jin HAN, So Young PARK, Min Hee HONG, Jii Bum LEE, Sun Min LIM, Jae-Hwan KIM, Kyoung-Ho PYO, Byoung Chul CHO   +19 more
doaj   +1 more source

Genome-wide analysis of genetic predisposition to Alzheimer’s disease and related sex disparities

Alzheimer’s Research & Therapy, 2019
Background Alzheimer’s disease (AD) is the most common cause of dementia in the elderly and the sixth leading cause of death in the United States. AD is mainly considered a complex disorder with polygenic inheritance.
Alireza Nazarian, Anatoliy I. Yashin, Alexander M. Kulminski   +2 more
doaj   +1 more source

The Genetic Predisposition and the Interplay of Host Genetics and Gut Microbiome in Crohn Disease [PDF]

Clinics in Laboratory Medicine, 2014
Extensive genetic studies have identified more than 140 loci predisposing to Crohn disease (CD). Several major CD susceptibility genes have been shown to impair biological function with regard to immune response to recognizing and clearance of bacterial infection.
openaire   +2 more sources

Sleep characteristics modify the association between genetic predisposition to obesity and anthropometric measurements in 119,679 UK Biobank participants [PDF]

, 2017
Background - Obesity is a multifactorial condition influenced by genetics, lifestyle and environment. Objective - To investigate whether the association between a validated genetic profile risk score for obesity (GPRS-obesity) with body mass index (BMI)
Bailey, Mark E.S., Biello, Stephany M., Celis-Morales, Carlos, Gill, Jason M.R., Guo, Yibing, Llamas, Daniel, Lyall, Donald M., Mackay, Daniel F., Pell, Jill P., Steell, Lewis, Ward, Joey   +10 more
core   +1 more source

A Novel Protein NAB1‐356 Encoded by circRNA circNAB1 Mitigates Atrial Fibrillation by Reducing Inflammation and Fibrosis

Advanced Science, EarlyView.
The circRNA circNAB1 is downregulated in AF patient. Silencing circNAB1 promotes collagen deposition and inflammation, whereas overexpression reduces AF susceptibility. circNAB1 encodes the protein NAB1 356 that interacts with EGR1 to mitigate fibrosis and inflammation.
William W Du, Muhammad Rafiq, Hui Yuan, Xiangmin Li, Sheng Wang, Jun Wu, Jinfeng Wei, Ren‐Ke Li, Huiming Guo, Burton B Yang   +9 more
wiley   +1 more source

Contrast‐enhanced micro‐computed tomography of compartment and time‐dependent changes in femoral cartilage and subchondral plate in a murine model of osteoarthritis

The Anatomical Record, Volume 306, Issue 1, Page 92-109, January 2023., 2023
Abstract A lack of understanding of the mechanisms underlying osteoarthritis (OA) progression limits the development of effective long‐term treatments. Quantitatively tracking spatiotemporal patterns of cartilage and bone degeneration is critical for assessment of more appropriately targeted OA therapies.
Deva D. Chan, Maleeha Mashiatulla, Jun Li, Ryan D. Ross, Meghana Pendyala, Amit Patwa, Mark W. Grinstaff, Anna Plaas, D. Rick Sumner   +8 more
wiley   +1 more source

Analysis of the human diseasome reveals phenotype modules across common, genetic, and infectious diseases [PDF]

, 2014
Phenotypes are the observable characteristics of an organism arising from its response to the environment. Phenotypes associated with engineered and natural genetic variation are widely recorded using phenotype ontologies in model organisms, as are signs and symptoms of human Mendelian diseases in databases such as OMIM and Orphanet.
arxiv   +1 more source

Rare germline variants in DNA repair genes and the angiogenesis pathway predispose prostate cancer patients to develop metastatic disease [PDF]

, 2018
Background Prostate cancer (PrCa) demonstrates a heterogeneous clinical presentation ranging from largely indolent to lethal. We sought to identify a signature of rare inherited variants that distinguishes between these two extreme phenotypes ...
A Liberzon, A McKenna, AA Al Olama, AG Vinuesa de, AH Ramos, AJ Vickers, B Sharma, C Cybulski, C Cybulski, C Deisenroth, CC Pritchard, Christopher A. Haiman, Clara Cieza-Borrella, CM Ewing, CM Gay, D Leongamornlert, D Li, Daniel A. Leongamornlert, David V. Conti, DC Koboldt, E Castro, E Castro, E Ruark, Edward J. Saunders, FR Schumacher, G Jun, Ian Whitmore, J Karar, J Li, J Niewiarowska, JB Hjelmborg, JI Jun, JL Beebe-Dimmer, K Yumoto, Koveela Govindasami, L Finney, LA Mucci, M Kircher, M Lek, M Martin, M Mongiat, MA Quintana, MA Quintana, Mark N. Brook, Martina Mijuskovic, P Dell’Oglio, PC Sham, R Bhati, R Lozano, R Na, RA Eeles, RD Wood, Rosalind A. Eeles, S Carbon, S Lee, S Purcell, Sarah Wakerell, SI Cunha, SM Gogarten, SN Hart, T Walsh, T Wei, The 1000 Genomes Project Consortium., Tokhir Dadaev, X Chang, X Liu, X Zhan, X Zheng, Y Gong, Z Kote-Jarai, Z Kote-Jarai, Zsofia Kote-Jarai   +71 more
core   +2 more sources

Gut Microbiota Colonization in Early Life Influences Susceptibility to Adulthood Hepatic Lipid Accumulation in High‐Fat‐Diet‐Fed Mice

Advanced Science, EarlyView.
This study indicates that perinatal antibiotic exposure elevates susceptibility to high‐fat‐diet‐induced hepatic lipid accumulation via disrupting early‐life gut microbiota colonization. The decreased Lactobacillus colonization inhibits primary‐to‐secondary bile acid conversion, lowering secondary bile acids, enhancing adulthood intestinal lipid ...
Yan‐Yan Zhu, Xin Dong, Hao Zhou, Ze‐Yan Li, Bo Wang, Ya‐Ping Song, Zhi‐Bing Liu, Xue Lu, Yi‐Hao Zhang, Yichao Huang, Hua Wang, De‐Xiang Xu   +11 more
wiley   +1 more source

How intelligence can change the course of evolution [PDF]

arXiv, 2017
The effect of phenotypic plasticity on evolution, the so-called Baldwin effect, has been studied extensively for more than 100 years. Plasticity is known to influence the speed of evolution towards a specific genetic configuration, but whether it also influences what that genetic configuration is, is still an open question.
arxiv