Results 71 to 80 of about 284,664 (210)

SUMOylation is a Translatable Target in Hypoxic MNPs Regulating Retinal Vasculopathy

Advanced Science, EarlyView.
During ischemic retinopathy/retinal vasculopathy, UBC9‐mediated SUMOylation in retinal macrophages enhances their pro‐angiogenic capacity via hypoxia‐induced SUMOylation of FUS at K327/K502. This modification suppresses FUS binding to the Vegfa mRNA 3’UTR, stabilizing transcripts and facilitating VEGFA production. Targeting UBC9 inhibition can serve as
Zheng Zhong, Guangyu Liang, Huimin Yu, Jiaqi Li, Ruohong Wang, Xiaohong Ma, Ziqing Zhou, Yin Zhao, Fei Sun, Xufang Sun   +9 more
wiley   +1 more source

Inhibition of Heat Shock Protein 90β by Catalpol: A Potential Therapeutic Approach for Alleviating Inflammation‐Induced Cartilage Injuries in Osteoarthritis

Advanced Science, EarlyView.
The schematic diagram delineates the chondroprotective effects of Ca‐bMSN in OA models. The upper portion of the diagram depicts the synthesis process of Ca‐bMSN. The lower section illustrates the post‐injection of Ca‐bMSN in joint cavity, catalpol released and subsequently mediates the reduction of oxidative stress, ECM catabolism, apoptosis, and ...
Zhenwei Zhou, Binghua Zhang, Lang Liu, Jie Yang, Yuting Wang, Cheng Lv, He Zhang, Yuchi Wei, Zhanliang Jiang, Zeyu Peng, Daqing Zhao, Xiangyang Leng, Xiangyan Li, Hang Su, Haisi Dong   +14 more
wiley   +1 more source

Genetic Information and the Workplace - Full Report [PDF]

, 1998
Joint Agency ReportGeneticInfoWorkplace1998.pdf: 800 downloads, before Oct.
Department of Health and Human Services, U.S., Department of Labor, U.S., Equal Employment Opportunity Commission, U.S.   +2 more
core   +1 more source

Akkermansia Muciniphila Alleviates Severe Acute Pancreatitis via Amuc1409‐Ube2k‐Foxp3 Axis in Regulatory T Cells

Advanced Science, EarlyView.
Akkermansia depletion correlates with acute pancreatitis (AP) severity. A. muciniphila and its protein Amuc_1409 mitigate pancreatic/systemic inflammation by expanding Tregs and IL‐10. Mechanistically, Amuc_1409 binds Ube2k, inhibiting Foxp3 ubiquitination to stabilize Treg differentiation and IL‐10 production, countering SAP‐induced SIRS/CARS ...
Jinyan Xie, Lijun Du, Yunkun Lu, Xiuliu Guo, Xinyuan Zhou, Yifan Tong, Bo Shen, Xin Yu, Feng Guo, Hong Yu   +9 more
wiley   +1 more source

Frontiers in Nondrug Treatment of Sarcopenia: A Review of Pathological Mechanisms and the Latest Treatment Strategies

AGING MEDICINE, EarlyView.
This article mainly introduces the pathologic process of sarcopenia and the recent progress in diagnosis and treatment, especially the nondrug treatment. ABSTRACT Sarcopenia refers to the progressive decline and wasting of skeletal muscle function, typically linked to aging or as a secondary effect of various conditions, including systemic inflammation,
Qi‐Fei Kuang, Yu‐Qing Ni, You‐Shuo Liu   +2 more
wiley   +1 more source

Genetic predisposition to thrombophilia in inflammatory bowel disease [PDF]

, 2011
BRAVATA', Ivana, CAMMA', Calogero, Cappello, M, CRAXI, Antonio, GRIMAUDO, Stefania, LICATA, Anna, PIPITONE, Rosaria Maria, RANDAZZO, Claudia   +7 more
core   +2 more sources

Measuring specialty crop grower willingness to pay for genetic modification and genetic editing

Agribusiness, EarlyView.
Abstract In contrast to the widespread adoption of agricultural commodities modified using biotechnology, the adoption rate of bioengineered specialty crops by growers remains low. The use of bioengineered crops has been controversial since their introduction in the 1990s due to concerns about their potentially harmful effects to human health, the ...
Marie Abbey, Alan G. Smith, Chengyan Yue, Corissa Marson, Yufeng Lai, Carrie Stowers   +5 more
wiley   +1 more source

Impact of primary tumor clinicopathological factors on prognosis after hepatic resection for rectal liver metastases

Annals of Gastroenterological Surgery, EarlyView.
This retrospective study evaluates the prognostic factors in patients undergoing curative hepatic resection for rectal cancer liver metastases. It identifies lateral lymph node metastasis and perineural invasion as significant prognostic factors. Moreover, patients with these factors required nonsurgical treatment in the early postoperative period ...
Tomofumi Uotani, Takeshi Takamoto, Satoshi Nara, Daisuke Ban, Takahiro Mizui, Konosuke Moritani, Shunsuke Tsukamoto, Yukihide Kanemitsu, Tsutomu Fujii, Minoru Esaki   +9 more
wiley   +1 more source

Nutritional benefits of pancreas‐sparing total duodenectomy for severe duodenal polyposis in patients with familial adenomatous polyposis

Annals of Gastroenterological Surgery, EarlyView.
The postoperative nutritional status of patients with familial adenomatous polyposis who underwent pancreas‐sparing total duodenectomy was better than that of patients who underwent pancreaticoduodenectomy. This study provides the first direct comparison of postoperative nutritional outcomes between patients with pancreas‐sparing total duodenectomy and
Ibuki Fujinuma, Toshiro Ogura, Ayano Takahashi, Satoshi Nomura, Kei Kitamura, Amane Takahashi, Takehiro Shiraishi, Yoshiko Mori, Toru Ishiguro, Takatoshi Matsuyama, Youichi Kumagai, Hideyuki Ishida   +11 more
wiley   +1 more source

Outcomes of Genetic Testing in a Genitourinary Genetics Clinic [PDF]

, 2018
Several known hereditary cancer syndromes confer an increased risk for genitourinary (GU)related malignancies. Various guidelines indicate when to refer patients to genetic counseling for GU-related hereditary cancer syndromes but there is limited ...
Pace, Annelise
core   +1 more source