A Journey through Genetic Architecture and Predisposition of Coronary Artery Disease [PDF]
Current Genomics, 2020 Introduction: To halt the spread of coronary artery disease (CAD), the number one killer in the world, requires primary prevention. Fifty percent of all Americans are expected to experience a cardiac event; the challenge is identifying those at risk. 40 to 60% of predisposition to CAD is genetic. The first genetic risk variant, 9p21, was discovered in
Robert Roberts, Chih Chao Chang
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Genetic Predisposition Impacts Clinical Changes in a Lifestyle Coaching Program. [PDF]
, 2019 Both genetic and lifestyle factors contribute to an individual\u27s disease risk, suggesting a multi-omic approach is essential for personalized prevention.
Conomos, Matthew P +7 more
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Pilot GWAS of caries in African-Americans shows genetic heterogeneity
BMC Oral Health, 2019 Background Dental caries is the most common chronic disease in the US and disproportionately affects racial/ethnic minorities. Caries is heritable, and though genetic heterogeneity exists between ancestries for a substantial portion of loci associated ...
E. Orlova +8 more
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Modeling historical tuberculosis epidemics among Canadian First Nations: effects of malnutrition and genetic variation [PDF]
PeerJ, 2015 Late 19th century epidemics of tuberculosis (TB) in Western Canadian First Nations resulted in peak TB mortality rates more than six times the highest rates recorded in Europe.
Sarah F. Ackley +3 more
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CLINICAL AND GENETIC PARALLELS ALONG CELIAC DISEASE AMONG TOMSK CHILDREN
Педиатрическая фармакология, 2007 The article is devoted to the analysis of the genetic predisposition to celiac disease. The authors studied the associations of the HLA genes and modifier genes of the immune response (interleukine 1, inter leukine 1 receptor antagonist, inter leukine 4,
E.I. Kondrat’eva +5 more
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Relationship between polymorphisms of DNA repair gene ERCC1 and susceptibility to lung cancer
Chinese Journal of Lung Cancer, 2008 Background and objective The recent studies have demonstrated that polymorphisms of DNA repair genes can impact the tumor susceptibility. So the susceptible group can be chosen through analysis of different genotype of DNA repair genes and maybe get the ...
Bo SU +4 more
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Genetics of breast cancer: Contribution of BRCA1/2 genes alterations to hereditary predisposition [PDF]
Vojnosanitetski Pregled, 2012 nema
Branković-Magić Mirjana +2 more
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A continuum of psychosis, one human gene, and not much else - the case for homogeneity [PDF]
, 1995 The contention of this paper is that psychoses are not a collection of separate and unrelated diseases, but a set of diverse expressions of a single underlying entity.
Crow, Prof TJ
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Simple and Complex ABCR: Genetic Predisposition to Retinal Disease [PDF]
The American Journal of Human Genetics, 2000 Diseases of the retina include a wide spectrum of photoreceptor-affecting phenotypes that have been mapped to >120 loci on the human genome (RetNet Retinal Information Network). Currently, less than half of the causal genes have been identified (RetNet Retinal Information Network), although substantial progress has been made in determining the genetic ...
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Association Between IL-4 and IL-6 Expression Variants and Gastric Cancer Among Portuguese Population
GE: Portuguese Journal of Gastroenterology, 2015 Introduction: Multiple studies have reported strong associations between Helicobacter pylori (Hp) inflammation and gastric cancer (GC) development. Altered expressions of pro/anti-inflammatory cytokines have a crucial role in Hp and GC proliferation ...
Ana Maria Sampaio +6 more
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